Re-identification of c. 15 700 cal yr BP tephra bed at Kaipo Bog, eastern North Island: implications for dispersal of Rotorua and Puketarata tephra beds.

A 10 mm thick, c. 15 700 calendar yr BP (c. 13 100 14C yr BP) rhyolitic tephra bed in the well-studied montane Kaipo Bog sequence of eastern North Island was previously correlated with Maroa-derived Puketarata Tephra. We revise this correlation to Okataina-derived Rotorua Tephra based on new compositional data from biotite phenocrysts and glass. The new correlation limits the known dispersal of Puketarata Tephra (sensu stricto, c. 16 800 cal yr BP) and eliminates requirements to either reassess its age or to invoke dual Puketarata eruptive events. Our data show that Rotorua Tephra comprises two glass-shard types: an early-erupted low-K2O type that was dispersed mostly to the northwest, and a high-K2O type dispersed mostly to the south and southeast, contemporary with late-stage lava extrusion. Late-stage Rotorua eruptives contain biotite that is enriched in FeO compared with biotite from Puketarata pyroclastics. The occurrence of Rotorua Tephra in Kaipo Bog (100 km from the source) substantially extends its known distribution to the southeast. Our analyses demonstrate that unrecognised syn-eruption compositional and dispersal changes can cause errors in fingerprinting tephra deposits. However, the compositional complexity, once recognised, provides additional fingerprinting criteria, and also documents magmatic and dispersal processes

Electrokinetic contributions to self‐potential signals from magmatic stressing

This is the final version. Available on open access from the American Geophysical Union via the DOI in this recordPre‐eruptive electrical signals at active volcanoes are generally interpreted in terms of electrokinetic processes. Spatio‐temporal self‐potential (SP) signals can be caused by strain‐induced fluid flow in volcanic aquifers, however, previous studies lack the quantitative assessments of these phenomena and the underpinning poroelastic responses. Here we use Finite‐Element Analysis to study poroelastic responses induced by subsurface stressing from sill and dike sources by jointly solving for ground displacements, pore pressure and SP signals. We evaluate the influence of pressure source orientation on the poroelastic response in two different volcanic aquifers (pyroclastic and lava flow) to provide insights on emergent geodetic and SP signals and their sensitivity to governing parameters. Strain‐induced SP amplitudes deduced from a reference parameter set vary in both aquifer models and are of negative polarity (‐0.35 mV and ‐22.6 mV) for a pressurized dike and of positive polarity (+4 mV and +20 mV) for a pressurized sill. Importantly, we find uniquely different SP and ground displacement patterns from either sill or dike intrusions. Our study shows that SP signals are highly sensitive to the subsurface Young's modulus, streaming potential coupling coefficient and electrical conductivity of the poroelastic domains. For the set of parameters tested, the dike model predicts SP amplitudes of up to ‐947 mV which are broadly representative of recorded amplitudes from active volcanoes. Our study demonstrates that electrokinetic processes reflect magma‐induced stress and strain variations and highlights the potential of joint geodetic and SP studies to gain new insights on causes of volcanic unrest

Multiphysics modeling of volcanic unrest at Mt. Ruapehu (New Zealand)

This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record Data Availability Statement: No data were created or used for this research.Model scripts are available from http://zenodo.org (doi:10.5281/zenodo.7304472).Pre-eruptive signals at the crater lake-bearing Mt. Ruapehu (New Zealand) are either absent or hard to identify. Here, we report on geophysical anomalies arising from hydrothermal unrest (HTU) and magmatic unrest (MU) using multiphysics numerical modeling. Distinct spatio-temporal anomalies are revealed when jointly solving for ground displacements and changes in gravitational and electrical potential fields for a set of subsurface disturbances including magma recharge and anomalous hydrothermal flow. Protracted hydrothermal injections induce measurable surface displacements ( > 0.5 cm) at Ruapehu’s summit plateau, while magmatic pressurization (5 - 20 MPa) results in ground displacements below detection limits. Source density changes of 10 kg/m3 (MU simulations) and CO2 fluxes between 2150 and 3600 t/d (HTU simulations) induce resolvable residual gravity changes between +8 and -8 μGal at the plateau. Absolute self-potential anomalies are predicted to vary between 0.3 mV and 2.5 mV for all unrest simulations and exceed the detection limit of conventional electric surveying. Parameter space exploration indicates that variations of up to 400% in the Biot-Willis coefficient produce negligible differences in surface displacement in MU simulations, but strongly impact surface displacement in HTU simulations. Our interpretation of the findings is that monitoring of changes in self-potential and gravity should permit insights into MU at Ruapehu, while HTU is best characterised using ground displacements, residual gravity changes and self-potential anomalies. Our findings are useful to inform multiparameter monitoring strategies at Ruapehu and other volcanoes hosting crater lakes.Natural Environment Research CouncilNew Zealand Ministry of Business, Innovation and EmploymentCASE partner GNS Science and DEVORAGNCS-INDA

Phase relationships in two-dimensional mass spectrometry

Two-dimensional mass spectrometry (2D MS) is a data-independent tandem mass spectrometry technique in which precursor and fragment ion species can be correlated without the need for prior ion isolation. The behavior of phase in 2D Fourier transform mass spectrometry is investigated with respect to the calculation of phase-corrected absorption-mode 2D mass spectra. 2D MS datasets have a phase that is defined differently in each dimension. In both dimensions, the phase behavior of precursor and fragment ions is found to be different. The dependence of the phase for both precursor and fragment ion signals on various parameters (e.g., modulation frequency, shape of the fragmentation zone) is discussed. Experimental data confirms the theoretical calculations of the phase in each dimension. Understanding the phase relationships in a 2D mass spectrum is beneficial to the development of possible algorithms for phase correction, which may improve both the signal-to-noise ratio and the resolving power of peaks in 2D mass spectra

Seropositivity for CMV and IL-6 levels are associated with grip strength and muscle size in the elderly

BACKGROUND: Sarcopenia is an important cause of morbidity and mortality in older adults, with immunosenescence and inflammation being possible underlying mechanisms. We investigated the relationship between latent cytomegalovirus (CMV) infection, Interleukin 6 (IL-6) levels, muscle size and strength in a group of healthy older community-dwelling people. METHODS: Participants were healthy volunteers from the Lothian Birth Cohort 1936 study. Participants had IL-6 level and CMV antibody titre measured at age 70 years and grip strength and a volumetric T1-weighted MRI brain scan (allowing measurement of neck muscle cross-sectional area (CSA)) at age 73. Markers of childhood deprivation were adjusted for in the analysis due to correlations between childhood deprivation and latent CMV infection. RESULTS: 866 participants were studied; 448 men (mean age 72.48 years, sd 0.70) and 418 women (mean age 72.51 years, sd 0.72). In men, CMV seropositivity was associated with smaller neck muscle CSA (p = 0.03, partial eta squared = 0.01), even after adjustment for IL-6 levels. Neck muscle CSA was not associated with CMV seropositivity in women, or CMV antibody titre or IL-6 level in either sex. Grip strength associated negatively with IL-6 level (right grip strength p<0.00001, partial eta squared 0.032 and left grip strength p<0.00001, partial eta squared 0.027) with or without adjustment for CMV serostatus or antibody titre. CMV status and antibody titre were not significantly associated with grip strength in either hand. CONCLUSION: These findings support the hypothesis that there is a relationship between markers of immunosenescence (i.e. CMV serostatus and IL6 level) and low muscle mass and strength and longitudinal studies in older cohorts are now required to investigate these relationships further

Phreatic eruptions at crater lakes: occurrence statistics and probabilistic hazard forecast

Phreatic eruptions, although posing a serious threat to people in crater proximity, are often underestimated and have been comparatively understudied. The detailed eruption catalogue for Ruapehu Volcano (New Zealand) provides an exceptional opportunity to study the statistics of recurring phreatic explosions at a crater lake volcano. We performed a statistical analysis on this phreatic eruption database, which suggests that phreatic events at Ruapehu do not follow a Poisson process. Instead they tend to cluster, which is possibly linked to an increased heat flow during periods of a more shallow-seated magma column. Larger explosions are more likely to follow shortly after smaller events, as opposed to longer periods of quiescence. The absolute probability for a phreatic explosion to occur at Ruapehu within the next month is about 10%, when averaging over the last 70 years of recording. However, the frequency of phreatic explosions is significantly higher than the background level in years prior to magmatic episodes. Combining clast ejection simulations with a Bayesian event tree tool (PyBetVH) we perform a probabilistic assessment of the hazard due to ballistic ejecta in the summit area of Ruapehu, which is frequently visited by hikers. Resulting hazard maps show that the absolute probability for the summit to be affected by ballistics within the next month is up to 6%. The hazard is especially high on the northern lakeshore, where there is a mountain refuge. Our results contribute to the local hazard assessment as well as the general perception of hazards due to steam-driven explosions

Reliability of goniometric measurements in children with cerebral palsy: A comparative analysis of universal goniometer and electronic inclinometer. A pilot study

<p>Abstract</p> <p>Background</p> <p>Even though technological progress has provided us with more and more sophisticated equipment for making goniometric measurements, the most commonly used clinical tools are still the universal goniometer and, to a lesser extent, the inclinometer. There is, however, no published study so far that uses an inclinometer for measurements in children with cerebral palsy (CP). The objective of this study was two-fold: to independently assess the intra and inter-examiner reliability for measuring the hip abduction range of motion in children with CP using two different instruments, the universal two-axis goniometer and electronic inclinometer. A pool of 5 examiners with different levels of experience as paediatric physiotherapists participated. The study did not compare both instruments because the measurement procedure and the hip position were different for each.</p> <p>Methods</p> <p>A prospective, observational study of goniometery was carried out with 14 lower extremities of 7 children with spastic CP. The inclinometer study was carried out with 8 lower extremities of 4 children with spastic CP. This study was divided into two independent parts: a study of the reliability of the hip abduction range of motion measured with a universal goniometer (hip at 0° flexion) and with an electronic inclinometer (hip at 90° flexion). The Intraclass Correlation Coefficient (ICC) was calculated to analyse intra and inter-examiner agreement for each instrument.</p> <p>Results</p> <p>For the goniometer, the intra-examiner reliability was excellent (>0.80), while the inter-examiner reliability was low (0.375 and 0.475). For the inclinometer, both the intra-examiner (0.850-0.975) and inter-examiner reliability were excellent (0.965 and 0.979).</p> <p>Conclusions</p> <p>The inter-examiner reliability for goniometric measurement of hip abduction in children with CP was low, in keeping with other results found in previous publications. The inclinometer has proved to be a highly reliable tool for measuring the hip abduction range of motion in children with CP, which opens up new possibilities in this field, despite having some measurement limitations.</p

Impact of cancer and chemotherapy on autonomic nervous system function and cardiovascular reactivity in young adults with cancer: a case-controlled feasibility study

Background Preliminary evidence suggests cancer- and chemotherapy-related autonomic nervous system (ANS) dysfunction may contribute to the increased cardiovascular (CV) morbidity- and mortality-risks in cancer survivors. However, the reliability of these findings may have been jeopardized by inconsistent participant screening and assessment methods. Therefore, good laboratory practices must be established before the presence and nature of cancer-related autonomic dysfunction can be characterized. The purpose of this study was to assess the feasibility of conducting concurrent ANS and cardiovascular evaluations in young adult cancer patients, according to the following criteria: i) identifying methodological pitfalls and proposing good laboratory practice criteria for ANS testing in cancer, and ii) providing initial physiologic evidence of autonomic perturbations in cancer patients using the composite autonomic scoring scale (CASS). Methods Thirteen patients (mixed diagnoses) were assessed immediately before and after 4 cycles of chemotherapy. Their results were compared to 12 sex- and age-matched controls. ANS function was assessed using standardized tests of resting CV (tilt-table, respiratory sinus arrhythmia and Valsalva maneuver) and sudomotor (quantitative sudomotor axon reflex test) reactivity. Cardiovascular reactivity during exercise was assessed using a modified Astrand-Ryhming cycle ergometer protocol. Our feasibility criteria addressed: i) recruitment potential, ii) retention rates, iii) pre-chemotherapy assessment potential, iv) test performance/tolerability, and v) identification and minimizing the influence of potentially confounding medication. T-tests and repeated measures ANOVAs were used to assess between- and within-group differences at baseline and follow-up. Results The overall success rate in achieving our feasibility criteria was 98.4 %. According to the CASS, there was evidence of ANS impairment at baseline in 30.8 % of patients, which persisted in 18.2 % of patients at follow-up, compared to 0 % of controls at baseline or follow-up. Conclusions Results from our feasibility assessment suggest that the investigation of ANS function in young adult cancer patients undergoing chemotherapy is possible. To the best of our knowledge, this is the first study to report CASS-based evidence of ANS impairment and sudomotor dysfunction in any cancer population. Moreover, we provide evidence of cancer- and chemotherapy-related parasympathetic dysfunction – as a possible contributor to the pathogenesis of CV disease in cancer survivors

Tactual perception: a review of experimental variables and procedures

This paper reviews literature on tactual perception. Throughout this review we will highlight some of the most relevant variables in touch literature: interaction between touch and other senses; type of stimuli, from abstract stimuli such as vibrations, to two- and three-dimensional stimuli, also considering concrete stimuli such as the relation between familiar and unfamiliar stimuli or the haptic perception of faces; type of participants, separating studies with blind participants, studies with children and adults, and an analysis of sex differences in performance; and finally, type of tactile exploration, considering conditions of active and passive touch, the relevance of movement in touch and the relation between exploration and time. This review intends to present an organised overview of the main variables in touch experiments, attending to the main findings described in literature, to guide the design of future works on tactual perception and memory.This work was funded by the Portuguese “Foundation for Science and Technology” through PhD scholarship SFRH/BD/35918/2007