18 research outputs found
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
- Collier D
- Collins R
- Coloma G
- Colquhoun D
- Colvin T
- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
- Cosgrove S
- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
- Cox R
- Craig W
- Crandall L
- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
- Dave K
- Davidsson K
- Davies M
- Davies N
- Davis B
- Davis M
- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
- Decsi Kl
- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
- Dhawan M
- Di Biase M
- Diago M
- Diaz M
- Dicken T
- Dickstein K
- Diederich C
- Diederich M
- Diehl R
- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
- Dobilas V
- Dodds G
- Doesborg L
- Doggett J
- Dognini Gp
- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
- Duff J
- Duhan S
- Dunhurst F
- Dussan Ma
- Dutka C
- Dwenger E
- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
- East C
- Eaton C
- Eaves W
- Ebeling K
- Ebrahim I
- Eccleston D
- Echeverria L
- Eder F
- Edgerton L
- Edillo C
- Edwards J
- Edwards T
- Eichinger G
- Einhorn D
- Eki Y
- El Hachem M
- El Hafi S
- Ellenbroek D
- Ellis M
- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
- F Fonseca
- F Fucci
- Facello A
- Facello M
- Faghih M
- Fail P
- Falcon D
- Fang C
- Fang Cy
- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
- Felix L
- Feng Y
- Feng Z
- Ferdinand K
- Ferkl R
- Fernandez Aa
- Ferrari V
- Ferrario M
- Ferraz R
- Ferreira Dos Santos T
- Ferreira-Jardim A
- Fien E
- Filardi Pp
- Filho P
- Fintel D
- Firek C
- Fischer Sm
- Fisher J
- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
- Flores E
- Flores Gs
- Flores H
- Floro T
- Foerster A
- Folkeringa Rj
- Fonseca A
- Fontaine S
- Forgon T
- Forgosh L
- Forker A
- Forster T
- Foster M
- Foucauld J
- Fowler V
- Fox B
- Franco M
- Francoeur L
- Frandsen B
- Frandsen B
- Frankenstein L
- Fratczak M
- Freitas E
- French J
- Frivold G
- Fruchter G
- Fu G
- Fucak E
- Fuchs R
- Fucili A
- Fukuike C
- Fullerton D
- Fulop P
- Fulop T
- Fulwani M
- Furch G
- Furuseth B
- G Gacioch
- G Gosselin
- Gabito A
- Gabor M
- Gabriel J
- Gabrielli D
- Gaeb-Strasas B
- Gamba C
- Ganau A
- Gapon L
- Garas S
- Garcia Duran R
- Garcia Pinna J
- Garcia Rinaldi R
- Garcia F
- Garcia N
- Garcia-Fragoso V
- Garcia-Portela M
- Garner K
- Gazizianova V
- Gelb R
- Genest J
- Genova D
- George F
- Germann H
- Gersh B
- Gervais B
- Ghali J
- Ghondale N
- Ghosh N
- Ghosh S
- Giese C
- Gilbert J
- Gilley J
- Gits F
- Glancy R
- Glenny J
- Glover J
- Glynn Rj
- Godoy Sanchez M
- Goette A
- Goff R
- Goffinet C
- Gohel P
- Goldberg N
- Gomez Sanchez J
- Gonsorcik J
- Gonzales D
- Gonzales V
- Gonzalez E
- Gordeev I
- Gorges R
- Gospodinov K
- Gotcheva N
- Goudev A
- Gould R
- Govindaraj D
- Goyal B
- Goyal S
- Grabeau R
- Grable M
- Graham J
- Graham Ja
- Graif J
- Gralow J
- Gravellone M
- Gravenhorst-Muenter U
- Green E
- Greener R
- Greenway F
- Grieshaber V
- Griffin S
- Grigaraviciene I
- Grigorova V
- Gros C
- Grosse A
- Grover A
- Grundtvig M
- Gudipati Rvc
- Guerrero A
- Guillinta P
- Gundala Ak
- Gupta A
- Gupta A
- Gupta M
- Gupta V
- Gutmann J
- Guzman I
- Guzman P
- Gwyn M
- Gyorgyova E
- H Haldane
- H Hansen
- H Haught
- H Hill
- Haase F
- Haege R
- Haenel T
- Hage F
- Hageman T
- Hagemann D
- Hagenow A
- Hagiwara Y
- Haidar A
- Haider K
- Hakas J
- Haldis T
- Hall C
- Hall L
- Hall S
- Halliwell Tc
- Halpern S
- Hamer Bjb
- Hamud-Socoro A
- Han B
- Han S
- Hanak P
- Hanefeld M
- Hangyal T
- Hansson A
- Hanustiakova A
- Hao Y
- Hardas S
- Hardee L
- Harrell W
- Harrington A
- Harris B
- Hartleib M
- Hartwell J
- Hasan F
- Hasbani E
- Hasegawa K
- Hattler B
- Haughton G
- Haynes E
- Haywood A
- He Y
- He Z
- Heaney L
- Hecht J
- Heeren G
- Hegedus V
- Heider J
- Heisters J
- Henley L
- Hennig D
- Henriksson A
- Hermans K
- Hernandez E
- Hernandez I
- Hernandez M
- Hernández N
- Herrman Jp
- Herzog W
- Hess E
- Hettwer Magedanz E
- Hickey L
- Hiden C
- Hielscher S
- Higuchi T
- Higuchi Y
- Hilkert R
- Hilton T
- Himpel-Boenninghoff A
- Hinderaker P
- Hioki M
- Hirayama A
- Hiroma J
- Ho Cj
- Hodnett P
- Hoffman M
- Hofsoey K
- Hogan C
- Hollanders G
- Holmes Z
- Holoubek D
- Holscher A
- Hominal M
- Homza M
- Hong T
- Hong T
- Hoogslag Pam
- Horackova K
- Horak A
- Hornig M
- Horvat P
- Hosokawa S
- Hotchkiss D
- Houra M
- Hristova K
- Hsieh Ic
- Huang A
- Huang P
- Huang Ph
- Humbert J
- Hurtig U
- Hutchens E
- Huynh T
- Hwang Jj
- Hwang Jj
- Hyun K
- Härstedt N
- Høivik Ho
- I Ilic
- I Ivanov
- Iachini K
- Iannopollo G
- Ibarra J
- Ibarra M
- Ibañez J
- Iby M
- Ichisawa M
- Igbokidi O
- Iijima T
- Ilahi T
- Ilic S
- Ilsley M
- Imbrognio M
- Imre Bs
- Inada T
- Inagaki M
- Indolfi C
- Infusino F
- Invitti C
- Ipp E
- Isaza D
- Istratoaie O
- Istvan Kp
- Iteld B
- Ito K
- Ivan P
- Iveta H
- Izmozherova N
- J Jiang
- J Johnson
- J Johnston
- J Jose
- Jacques G
- Jafri A
- Jafry B
- Jagtap P
- Jaguszewska G
- Jain A
- Jansen M
- Jardula M
- Jayasinghe R
- Jefferson D
- Jenkins R
- Jensen Ed
- Jeric M
- Jerzewski A
- Jeserich M
- Jia Z
- Jiang T
- Jiang X
- Jimenez D
- Jirvankar P
- Johansen Bb
- Johansen E
- Johansson K
- Johnson E
- Jones S
- Jonsson Je
- Joosten C
- Joshi U
- Julien Ve
- Julião K
- Jure D
- Jure H
- Jutrisa N
- K Kaigawa
- K Katahira
- K Kiroglu
- K Kordic
- K Kostov
- Kabakchieva Vm
- Kaczmarek N
- Kafarakis P
- Kaiserova L
- Kajihara S
- Kala P
- Kaldara E
- Kalina A
- Kalkman C
- Kam J
- Kamensky G
- Kamiya H
- Kamiya J
- Kan G
- Kaneno Y
- Kanitz S
- Kapp I
- Kara Yd
- Karakai H
- Karel I
- Karpuram M
- Karsai Xz
- Kastelein Jjp
- Kataoka M
- Katona A
- Katova T
- Kaur H
- Kawahara M
- Kawai M
- Kawasaki T
- Kawka-Urbanek T
- Kazanskay E
- Ke Y
- Keba E
- Keenan S
- Kelehan S
- Kellnerova I
- Kelly R
- Kelt T
- Kendall T
- Kereiakes D
- Khan A
- Khan M
- Khan R
- Khan S
- Khariouzov A
- Khirmanov V
- Khromtsova O
- Kick J
- Kiefer R
- Kietselaer B
- Kim B
- Kim Ks
- Kim M
- Kimmel M
- King A
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- Kirkland S
- Kiss Rg
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- Kitchens D
- Klamm M
- Klein C
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- Klemsdal To
- Kleve R
- Klugherz B
- Knight J
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- Kobalava Z
- Kodem Dr
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- Kojima E
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- Koleckar P
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- Kolleroy C
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- Komati S
- Komura Y
- Kondagunta V
- Konradi A
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- Kopczyńska M
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- Kosmacheva E
- Kostakou P
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- Kovacic D
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- Krapivsky A
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- Kreutter F
- Krupciakova B
- Krupicka J
- Kuenzler J
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- Kulkarni L
- Kullal P
- Kultursay H
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- Kumbla M
- Kuntzsch A
- Kuo Jy
- Kuramochi T
- Kuruma T
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- L Lim
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- Labovitz R
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- Ledger G
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- Ligueros M
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- Lorenzatti A
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- Lucksinger G
- Luecke-Uzar M
- Luedemann J
- Lukac J
- Lundqvist M
- Lupkovics G
- Luquez H
- Luz Serrano H
- Lv Y
- Lynd S
- Lysek R
- Lönnberg I
- M Malek
- M Mallagray
- M Mandati
- M Mandviwala
- M Marsters
- M Mays
- M Mcdonald
- M Medvegy
- M Meinrich
- M Mikus
- M Milanova
- M Moustafa
- Ma C
- Ma G
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- Macdonald J
- Macfadyen Jg
- Machova V
- Madder R
- Maehara G
- Maffei L
- Magness K
- Maheshwari A
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- Maia L
- Majercak I
- Majul C
- Makedonska Jj
- Makhe B
- Makotoko E
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- Malhotra S
- Malhotra V
- Malik J
- Mancikova I
- Mandic L
- Manenti E
- Manfreda S
- Manga P
- Mani Ck
- Mani H
- Manne S
- Manning B
- Mannucci E
- Manolis A
- Manolis Aj
- Manov E
- Mantas I
- Manuel J
- Manukov D
- Manukov I
- Manyari D
- Manzur F
- Marcela Wenetz Lm
- Marchelletta N
- Marchi Al
- Marcinkeviciene J
- Marcun R
- Marengo Garcia De Carvalho L
- Marinaro S
- Marino P
- Mariottoni B
- Maron B
- Marschke T
- Marshall L
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- Martinez J
- Maruzzo S
- Marziali A
- Masarikova L
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- Mathew A
- Matyasek I
- Mauersberger K
- Maus O
- Mavromatis K
- Maximov D
- Mayer T
- Maynard R
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- Mazutavicius R
- Mbulaiteye A
- Mcalister R
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- Mccrary D Jr
- Mccullough-O'Brien H
- Mcgill J
- Mcgrew F
- Mcintosh C
- Mckenzie A
- Mckenzie C
- Mckibbin A
- Mclaurin B
- Mclellan Ba
- Mcmahon G
- Mcneil D
- Mcneill R
- Mcpherson C
- Medina F
- Megalou A
- Mehrle A
- Mehta A
- Mehta S
- Meijlis P
- Meissner A
- Mejia I
- Melbie K
- Mellberg L
- Melliza T
- Mendoza N
- Mendoza Y
- Mercuro G
- Merkely B
- Messina T
- Mestdagh I
- Meyer R
- Michalaros Y
- Michalska A
- Michaud N
- Michel K
- Mickel C
- Micko K
- Mihaly N
- Mikdadi G
- Mikusova T
- Milicic D
- Militaru C
- Miliuniene R
- Milkas A
- Miller A
- Miller C
- Miller G
- Miller R
- Miller W
- Minescu B
- Minocha G
- Mitchell J
- Mittal A
- Miyamoto T
- Moats Djr
- Modi R
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- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Lawson criterion for ignition exceeded in an inertial fusion experiment
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- Abu-Shawareb H
- Acree R
- Adams J
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- Addis B
- Aden R
- Adrian P
- Afeyan BB
- Aggleton M
- Aghaian L
- Aguirre A
- Aikens D
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- Albright BJ
- Albritton J
- Alcala J
- Alday C
- Alessi DA
- Alexander N
- Alfonso J
- Alfonso N
- Alger E
- Ali SJ
- Ali ZA
- Alley WE
- Amala P
- Amendt PA
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- Ammula S
- Amorin C
- Ampleford DJ
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- Anklam T
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- Vaher JL
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- VanQuinlan R
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- Wilkens H
- Wilkins P
- Wilks SC
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- Williams GJ
- Williams W
- Williams WH
- Wilson B
- Wilson DC
- Wilson E
- Wilson R
- Winters S
- Wisoff J
- Wittman M
- Wolfe J
- Wong A
- Wong KW
- Wong L
- Wong N
- Wood R
- Woodhouse D
- Woodruff J
- Woods DT
- Woods S
- Woodworth BN
- Wooten E
- Wootton A
- Work K
- Workman JB
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- Wuest C
- Wysocki FJ
- Xu H
- Yamaguchi M
- Yang B
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- Yatabe J
- Yeamans CB
- Yee BC
- Yi SA
- Yin L
- Young B
- Young CS
- Young CV
- Young P
- Youngblood K
- Zacharias R
- Zagaris G
- Zaitseva N
- Zaka F
- Ze F
- Zeiger B
- Zika M
- Zimmerman GB
- Zobrist T
- Zuegel JD
- Zylstra AB
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 06/07/2022
- Field of study
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37Â MJ of fusion for 1.92Â MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion
Other Compounds of the 5LFe(CO)2 1L Type
- Author
- A Stasunik
- B Fuchs
- C Zou
- CL Randolph
- D Catheline
- D Catheline
- DA Brown
- DA Brown
- DF Ross
- E Weiss
- EE Bunel
- G Schiavon
- G Thum
- GM Williams
- H Ma
- J Ellermann
- J Morrow
- JA Belmont
- JE Ellis
- JE Shade
- JG Afton
- JM Manriquez
- JP Blaha
- JP Blaha
- KH Pannell
- KH Pannell
- L Weber
- L Weber
- M Akita
- M Akita
- MB Humphrey
- ME Wright
- MN Golovin
- N El Murr
- P Eilbracht
- P Eilbracht
- RB King
- RB King
- RB King
- RB King
- RG Bray
- RJ Kazlauskas
- RJ Kazlauskas
- SE Jacobson
- SR Berryhill
- SR Berryhill
- TC Forschner
- TC Forschner
- TC Forschner
- TY Orlova
- TY Orlova
- TY Orlova
- TY Orlova
- V Guerchais
- WA Herrmann
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1988
- Field of study
Hedging in Presence of Crop Yield, Crop Revenue and Rainfall Insurance
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Simple allelic-phenotype diversity and differentiation statistics for allopolyploids.
- Author
- A Refoufi
- ABN Berglund
- AG Young
- AG Yunus
- AL Kahler
- AM Arft
- BS Weir
- BS Weir
- C Bouza
- C Brochmann
- D J Obbard
- DJ Obbard
- DL Hartl
- DL Rogers
- F Balloux
- F Rousset
- HN De Silva
- IJ Leitch
- J R Pannell
- J Ramsey
- J Ronfort
- J Wakeley
- J Wakeley
- JD Bever
- JL Hamrick
- JM Nassar
- KH Wolfe
- LR Dice
- M Nei
- M Nordborg
- M Nordborg
- MC Whitlock
- MG Chung
- MS Olson
- OJ Hardy
- OJ Hardy
- P Meerts
- PG Meirmans
- PH Thrall
- PK Gaur
- PW Hedrick
- R Bruvo
- RA Legatt
- RJ Bayer
- RL Wu
- RR Hudson
- RS Waples
- S A Harris
- S Wright
- SK Jain
- SL Krebs
- SM Prober
- SP Otto
- T Nagylaki
- WH Murdy
- Publication venue
- Publication date
- 01/01/2006
- Field of study
The analysis of genetic diversity within and between populations is a routine task in the study of diploid organisms. However, population genetic studies of polyploid organisms have been hampered by difficulties associated with scoring and interpreting molecular data. This occurs because the presence of multiple alleles at each locus often precludes the measurement of genotype or allele frequencies. In allopolyploids, the problem is compounded because genetically distinct isoloci frequently share alleles. As a result, analysis of genetic diversity patterns in allopolyploids has tended to rely on the interpretation of phenotype frequencies, which loses information available from allele composition. Here, we propose the use of a simple allelic-phenotype diversity statistic (H') that measures diversity as the average number of alleles by which pairs of individuals differ. This statistic can be extended to a population differentiation measure (F'ST), which is analogous to FST. We illustrate the behaviour of these statistics using coalescent computer simulations that show that F'ST behaves in a qualitatively similar way to FST, thus providing a useful way to quantify population differentiation in allopolyploid species
Chloroplast haplotype variation among monoecious and dioecious populations of Sagittaria latifolia (Alismataceae) in eastern North America
- Author
- Abbott RJ
- Abrahamson WG
- Arber A
- Avise JC
- Baker HG
- Barrett SCH
- Bogin C
- Bull JJ
- Darwin C
- Davis MB
- Delcourt PA
- Demesure B
- Dieffenbacher-Krall AC
- Dorado O
- Dorken ME
- Dorken ME
- Doyle JJ
- Ennos RA
- Griffin SR
- Haynes RR
- Heilbuth JC
- Holsinger KE
- Huff DR
- Jousselin E
- Maskas SD
- Muenchow G
- Pannell JR
- Pons O
- Pons O
- Renner SS
- Ridley HN
- Rohlf FJ
- Sarkissian TS
- Schneider S
- Sculthorpe CD
- Smith JG
- Soltis DE
- Stehlik I
- Taberlet P
- Weiblen GD
- Wolfe KH
- Wooten JW
- Zamudio KR
- Zurawski G
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Cytotoxic effects of two organotin compounds and their mode of inflicting cell death on four mammalian cancer cells
- Author
- A Garg
- A Gennari
- A Sen
- Armando Varela-Ramirez
- AW Brown
- BT Elie
- C Alzieu
- C Levinson
- DK Kim
- DM Park
- E Fortemps
- E Ito
- ER Jamieson
- FD Gomez
- GN Kaluderovic
- H Chojnacki
- I Tamm
- J Gui-bin
- J Merkord
- K Fent
- K Tomiyama
- Keith H. Pannell
- KH Jones
- KW Yip
- L Tian
- M Dylag
- M Gielen
- M Gielen
- MA Champ
- Margaret Costanzo
- MM Whalen
- N Hoti
- N Miyoshi
- N Shaik
- P Gunasekar
- Renato J. Aguilera
- RG Feldman
- RH Pieters
- RN Kapoor
- S Gómez-Ruiz
- SK Bailey
- SK Hadjikakou
- SK Thodupunoori
- T Hori
- VA Fadok
- VA Gant
- VC Moser
- VK Ngan
- VL Narayanan
- WD Ross
- WT Piver
- Yazmin P. Carrasco
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Simple allelic-phenotype diversity and differentiation statistics for allopolyploids
- Author
- A Refoufi
- ABN Berglund
- AG Young
- AG Yunus
- AL Kahler
- AM Arft
- BS Weir
- BS Weir
- C Bouza
- C Brochmann
- D J Obbard
- DJ Obbard
- DL Hartl
- DL Rogers
- F Balloux
- F Rousset
- HN De Silva
- IJ Leitch
- J R Pannell
- J Ramsey
- J Ronfort
- J Wakeley
- J Wakeley
- JD Bever
- JL Hamrick
- JM Nassar
- KH Wolfe
- LR Dice
- M Nei
- M Nordborg
- M Nordborg
- MC Whitlock
- MG Chung
- MS Olson
- OJ Hardy
- OJ Hardy
- P Meerts
- PG Meirmans
- PH Thrall
- PK Gaur
- PW Hedrick
- R Bruvo
- RA Legatt
- RJ Bayer
- RL Wu
- RR Hudson
- RS Waples
- S A Harris
- S Wright
- SK Jain
- SL Krebs
- SM Prober
- SP Otto
- T Nagylaki
- WH Murdy
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
An Improved Methodology for the Prediction of the Stress at Ultimate in Unbonded Internal and External Steel Tendons
- Author
- A Ghallab
- A Tam
- AASHTO
- AASHTO
- AASHTO (American Association of State Highway and Transportation Officials)
- AC Aparicio
- ACI (American Concrete Institute)
- ACICommittee318
- AE Naaman
- AE Naaman
- AE Naaman
- AE Naaman
- AE Naaman
- AH Mattock
- B El-Ariss
- C-K Ng
- CABR (China Academy of Building Research)
- CK Ng
- CL Roberts-Wollmann
- CSA
- DIN (Deutsches Institut fur Normung)
- E Al Timimi
- EN Allouche
- F Peng
- FM Alkhairi
- FN Pannell
- FTK Au
- G Du
- H Nassif
- KH Abdelkareem
- KL Chouinard
- LH Lee
- M Alqam
- M Harajli
- M Harajli
- MA Pisani
- MA Pisani
- MH Harajli
- MH Harajli
- MH Harajli
- N Cooke
- O Ozkul
- PR Chakrabarti
- PS Rao
- R Senthil
- S Mojtahedi
- T Lou
- WZ Zheng
- ZQ He
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Anions of the Type [5LFe(CO)2]- and Their Salts
- Author
- A Cutler
- A Sanders
- A Sanders
- A Wong
- A Wong
- A Wong
- AF Clifford
- AN Nesmeyanov
- AN Nesmeyanov
- AN Nesmeyanov
- AS Batsanov
- ATT Hsieh
- BE Bursten
- BK Nicholson
- BL Booth
- BL Booth
- C Combes
- CA Poffenberger
- CB Colburn
- CP Casey
- CP Casey
- CR Jablonski
- CU Pittman
- D Catheline
- D Catheline
- D Gudat
- D Miholova
- DA Ross
- DA White
- DE Rudisill
- DF Marten
- DF Shriver
- DJ Ciappenelli
- DL Reger
- E Lindner
- E Lindner
- EJ Crawford
- EJ Moore
- EJ Moore
- EK Barefield
- EO Fischer
- G Doyle
- G Fritz
- G Thum
- GA Artamkina
- GB McVicker
- GM Williams
- GO Evans
- GR Lee
- H Alper
- H Nakazawa
- H Stolzenberg
- HH Baer
- HR Allcock
- HR Allcock
- I Haiduc
- JA Gladysz
- JCTRB Laurent
- JE Ellis
- JE Ellis
- JE Ellis
- JE Ellis
- JM Burlitch
- JM Burlitch
- JP Blaha
- JP Blaha
- JR Moss
- JS Plotkin
- JW Faller
- K Inkrott
- K Yasufuku
- KAM Kremer
- KC Hodges
- KH Pannell
- KH Pannell
- LD Hutchins
- LI Denisovich
- LI Zakharkin
- M Akita
- M Cooke
- M Green
- M Huairang
- M Höfler
- M Malisch
- M Moran
- M Moran
- M Nitay
- M Nitay
- MA El-Hinnawi
- MA Huffman
- ME Wright
- MI Bruce
- MR Collier
- MY Darensbourg
- NE Murr
- P Braunstein
- P Eilbracht
- P Gusbeth
- P Klemarczyk
- P Legzdin
- P Panster
- P Reich-Rohrwig
- P.A. McArdle
- PE Chatham
- PJ Krusic
- PJ Krusic
- PS Waterman
- R Gompper
- RB King
- RB King
- RB King
- RB King
- RB King
- RB King
- RB King
- RB King
- RB King
- RB King
- RB King
- RB King
- RB King
- RB Petersen
- RE Dessy
- RE Dessy
- RE Dessy
- RH Fong
- RW Light
- S Araki
- SC Cohen
- SL Berryhill
- SR Berryhill
- T Bauch
- T Bodnar
- TC Forschner
- TC Forschner
- TH Whitesides
- TH Whitesides
- VN Pandey
- W Angerer
- W Angerer
- W Angerer
- W Malisch
- W Malisch
- W Malisch
- W Malisch
- W Malisch
- W Malisch
- W Malisch
- W Malisch
- W Malisch
- WA Herrmann
- WP Fehlhammer
- WP Fehlhammer
- WP Fehlhammer
- WP Fehlhammer
- WP Fehlhammer
- WP Giering
- WR Cullen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1988
- Field of study