Use and perception of collars for companion cats in New Zealand

Aims: To investigate public perceptions of the use of collars for companion cats in New Zealand. To understand perceptions around safety and efficacy of collar use. Methods: An online questionnaire was distributed to members of the public via social media. The questionnaire collected details of respondents, cat ownership status, and responses to a number of questions regarding collar use in cats. Data were analysed using SPSS analytical software v21.0 for Windows (IBM Inc., Chicago IL, USA). Results were considered significant if p≤0.05. Results: A total of 512 responses were collected, 393 (76.9%) respondents reported owning at least one cat at the time of survey, of which 141 (36.4%) stated that at least some of their cats wore collars and 211 (54%) had at least one of their cats micro-chipped. Of the respondents with a pet cat, 351 (90%) allowed their cats outdoor access at least some of the time. Respondents 20 used collars for identification, and to reduce predation of birds and other animals. Reasons for not using collars included cat intolerance of collars, repeated collar loss and concern over collar safety. Respondents felt collars could cause injury if caught on objects, or if too tight, and many believed ‘not all cats will tolerate a collar’. Significant differences were found between cat owners and non-owners regarding whether cats were important for pest control; whether cats will tolerate collars; whether being well fed influences cat hunting behaviour; whether cats should be kept indoors at night; and whether a cat without a collar was likely to be a stray. Respondents trusted veterinarians and the SPCA most as sources of pet care information. Conclusion: Collar use for companion cats in New Zealand appeared to be low. Cat owners perceived a number of barriers to the use of collars which may be imagined, or result from incorrect use. Collars may be useful for improving animal welfare allowing rapid identification , improved rates of returns to owners and prompt medical interventions in the case of injury. Collars with attached devices such as bells are also useful to reduce the impact of domestic cats on both native and introduced wildlife, and may improve public perceptions of stray/wandering cats. Relevance: A number of concerns have been raised in recent years about the negative impacts of cats on New Zealand’s natural environment, and the possibility of poor welfare among unowned cats. Understanding the perceived importance of cat collars and exploration of the perceived barriers to their use are vital to enhance our understanding of cat ownership, cat identification and impact of cat predation. This understanding can help to guide development of policies and practices to improve animal welfare, reduce the negative impact of pet predation, and promote responsible pet ownership

The development of a socio-economic model to promote women’s empowerment initiatives in the renewable energy sector of South Africa

This study investigates the main contributors that can positively influence the socio-economic empowerment of women in the renewable energy sector in the Republic of South Africa, and recommends new and innovative approaches to mainstream gender in the sector. Empirical evidence showed that ethical leadership positively influences good governance and successful women’s empowerment. The results also indicated that social investment and broad-based black economic empowerment positively influence successful women’s empowerment. Finally, the results indicated that sustainable programmes are a positive contributing factor to good governance. However, the respondents did not consider stakeholder engagement statistically significant to good governance or successful women’s empowerment. This study also has the potential to contribute to the improvement of impoverished communities in South Africa and elsewhere

On Statistical Mechanics Developments of Clan Concept in Multiparticle Production

Clan concept has been introduced in multiparticle dynamics in order to interpret the wide occurrence of negative binomial (NB) regularity in n-charged particle multiplicity distributions (MDs) in various high energy collisions. The centrality of clan concept led to the attempt to justify its occurrence within a statistical model of clan formation and evolution. In this framework all thermodynamical potentials have been explicitly calculated in terms of NB parameters. Interestingly it was found that NB parameter k corresponds to the one particle canonical partition function. The goal of this paper is to explore a possible temperature and volume dependence of parameter k in various classes of events in high energy hadron-hadron collisions. It is shown that the existence of a phase transition at parton level from the ideal clan gas associated to the semihard component with k>1 to the ideal clan gas of the hard component with k<1 implies a discontinuity in the average number of particles at hadron level.Comment: 20 pages, latex, no figures; v2: the description of the framework has been considerably expanded, and the main body has been reorganized for clarit

Curriculum implementation exploratory studies: Final report

Throughout the history of schooling in New Zealand the national curriculum has been revised at fairly regular intervals. Consequently, schools are periodically faced with having to accommodate to new curriculum. In between major changes other specifically-focused changes may arise; for example, the increased recent emphasis upon numeracy and literacy

Religious perspectives on the use of psychopharmaceuticals as an enhancement technology

The use of psychopharmaceuticals as an enhancement technology has been the focus of attention in the bioethics literature. However, there has been little examination of the challenges that this practice creates for religious traditions that place importance on questions of being, authenticity and identity. We asked expert commentators from six major world religions to consider the issues raised by psychopharmaceuticals as an enhancement technology. These commentaries reveal that in assessing the appropriate place of medical therapies, religious traditions, like secular perspectives, rely upon ideas about health and disease and about normal human behavior. But unlike secular perspectives, faith traditions explicitly concern themselves with ways in which medicine should or should not be used to live a ‘good life’. KEYWORDS: Enhancement; bioethics, psychopharmacology, religio

Development and validation of a risk calculator for major mood disorders among the offspring of bipolar parents using information collected in routine clinical practice.

Family history is a significant risk factor for bipolar disorders (BD), but the magnitude of risk varies considerably between individuals within and across families. Accurate risk estimation may increase motivation to reduce modifiable risk exposures and identify individuals appropriate for monitoring over the peak risk period. Our objective was to develop and independently replicate an individual risk calculator for bipolar spectrum disorders among the offspring of BD parents using data collected in routine clinical practice. Data from the longitudinal Canadian High-Risk Offspring cohort study collected from 1996 to 2020 informed the development of a 5 and 10-year risk calculator using parametric time-to-event models with a cure fraction and a generalized gamma distribution. The calculator was then externally validated using data from the Lausanne-Geneva High-Risk Offspring cohort study collected from 1996 to 2020. A time-varying C-index by age in years was used to estimate the probability that the model correctly classified risk. Bias corrected estimates and 95% confidence limits were derived using a jackknife resampling approach. The primary outcome was age of onset of a major mood disorder. The risk calculator was most accurate at classifying risk in mid to late adolescence in the Canadian cohort (n = 285), and a similar pattern was replicated in the Swiss cohort (n = 128). Specifically, the time-varying C-index indicated that there was approximately a 70% chance that the model would correctly predict which of two 15-year-olds would be more likely to develop the outcome in the future. External validation within a smaller Swiss cohort showed mixed results. Findings suggest that this model may be a useful clinical tool in routine practice for improved individualized risk estimation of bipolar spectrum disorders among the adolescent offspring of a BD parent; however, risk estimation in younger high-risk offspring is less accurate, perhaps reflecting the evolving nature of psychopathology in early childhood. Based on external validation with a Swiss cohort, the risk calculator may not be as predictive in more heterogenous high-risk populations. The Canadian High-Risk Study has been funded by consecutive operating grants from the Canadian Institutes for Health Research, currently CIHR PJT Grant 152796 he Lausanne-Geneva high-risk study was and is supported by five grants from the Swiss National Foundation (#3200-040,677, #32003B-105,969, #32003B-118,326, #3200-049,746 and #3200-061,974), three grants from the Swiss National Foundation for the National Centres of Competence in Research project "The Synaptic Bases of Mental Diseases" (#125,759, #158,776, and #51NF40 - 185,897), and a grant from GlaxoSmithKline Clinical Genetics

Structural and functional characterization of the interaction between the influenza A virus RNA polymerase and the CTD of host RNA polymerase II

Influenza A viruses, causing seasonal epidemics and occasional pandemics, rely on interactions with host proteins for their RNA genome transcription and replication. The viral RNA polymerase utilizes host RNA polymerase II (Pol II) and interacts with the serine 5 phosphorylated (pS5) C-terminal domain (CTD) of Pol II to initiate transcription. Our study, using single-particle electron cryomicroscopy (cryo-EM), reveals the structure of the 1918 pandemic influenza A virus polymerase bound to a synthetic pS5 CTD peptide composed of four heptad repeats mimicking the 52 heptad repeat mammalian Pol II CTD. The structure shows that the CTD peptide binds at the C-terminal domain of the PA viral polymerase subunit (PA-C) and reveals a previously unobserved position of the 627 domain of the PB2 subunit near the CTD. We identify crucial residues of the CTD peptide that mediate interactions with positively charged cavities on PA-C, explaining the preference of the viral polymerase for pS5 CTD. Functional analysis of mutants targeting the CTD-binding site within PA-C reveals reduced transcriptional function or defects in replication, highlighting the multifunctional role of PA-C in viral RNA synthesis. Our study provides insights into the structural and functional aspects of the influenza virus polymerase-host Pol II interaction and identifies a target for antiviral development