Psychiatric Diagnoses in Patients with Williams Syndrome and Their Families

Williams Syndrome (WS) is a genetic disorder associated with mental retardation (MR) and a distinct behavioral phenotype including a friendly and outgoing personality. This population, like others with MR, has been reported to have an increased rate of symptoms of mental illness; however, few studies have used DSM-IV criteria to quantify specific psychiatric diagnoses in WS and the prevalence of psychiatric illness in relatives of individuals with WS and the possible relationship between family and patient diagnoses is currently unknown. Methods: Twenty-one families participated; the patients’ average age was 16 years. DSM-IV diagnoses were applied by using the Anxiety Disorders Interview Schedule (ADIS, Parent and Child Versions) and the Family History Screen. Results: A diagnosis from the ADIS was applicable to 13 patients (62%), and in 16 patients (76%) a diagnosis was applicable in their first-degree family members. Ten patients (48%) had some form of anxiety, specific phobia being the most common. Three patients (14%) had major depressive disorder and 9 patients (43%) had attention-deficit/hyperactivity disorder (ADHD). The presence of anxiety or mood disorders in patients with WS and the presence of these disorders in their family members were unrelated. Conclusions: Patients with WS have a high prevalence of anxiety disorders and of ADHD. The presence of psychiatric disorders in WS did not appear to have a significant relationship to family history of psychiatric disorders, consistent with the hypothesis that the specific genetic alteration in WS causes, or contributes to causing, the anxiety disorders and the ADHD that are so common in the disorder

Structured illumination microscopy using micro-pixellated light-emitting diodes

Structured illumination is a flexible and economical method of obtaining optical sectioning in wide-field microscopy [1]. In this technique the illumination system is modified to project a single-spatial frequency grid pattern onto the sample [2, 3]. The pattern can only be resolved in the focal plane and by recording images for different transverse grid positions (or phases) an image of the in-focus parts of the object can be calculated. Light emitting diodes (LEDs) are becoming increasingly popular for lighting and illumination systems due to their low cost, small dimensions, low coherence, uniform illumination, high efficiency and long lifetime. These properties, together with recent developments in high brightness, ultraviolet operation and microstructured emitter design offer great potential for LEDs as light sources for microscopy. In this paper we demonstrate a novel structured illumination microscope using a blue micro-structured light emitting diode as the illumination source. The system is potentially very compact and has no-moving-parts

Probabilistically Accurate Program Transformations

18th International Symposium, SAS 2011, Venice, Italy, September 14-16, 2011. ProceedingsThe standard approach to program transformation involves the use of discrete logical reasoning to prove that the transformation does not change the observable semantics of the program. We propose a new approach that, in contrast, uses probabilistic reasoning to justify the application of transformations that may change, within probabilistic accuracy bounds, the result that the program produces. Our new approach produces probabilistic guarantees of the form ℙ(|D| ≥ B) ≤ ε, ε ∈ (0, 1), where D is the difference between the results that the transformed and original programs produce, B is an acceptability bound on the absolute value of D, and ε is the maximum acceptable probability of observing large |D|. We show how to use our approach to justify the application of loop perforation (which transforms loops to execute fewer iterations) to a set of computational patterns.National Science Foundation (U.S.) (Grant CCF-0811397)National Science Foundation (U.S.) (Grant CCF-0905244)National Science Foundation (U.S.) (Grant CCF-1036241)National Science Foundation (U.S.) (Grant IIS-0835652)United States. Dept. of Energy (Grant DE-SC0005288

Novel resources: opportunities for and risks to species conservation

During the Anthropocene, ongoing rapid environmental changes are exposing many species to novel resources. However, scientists’ understanding of what novel resources are and how they impact species is still rudimentary. Here, we used a resource‐based approach to explore novel resources. First, we conceptualized novel resource use by species along two dimensions of novelty: namely, ecosystem novelty and resource novelty. We then examined characteristics that influence a species’ response to a novel resource and how novel resources can affect individuals, populations, species, and communities. In addition, we discuss potential management complications associated with novel resource use by threatened species. As conservation and management embrace global environmental change, it is critical that ecologists improve the current understanding of the opportunities and risks that novel resources present to species conservation

Patient Perspectives of Rural Kansas Maternity Care

Introduction. Pregnant women in rural areas face a unique set of challenges due to geographic maldistribution of obstetric services. The perspectives of rural Kansas women were sought regarding experience of birth and satisfaction with maternity care. Methods. Medical student research assistants facilitated discussion groups in rural Kansas communities with women who had given birth in the last 24 months. Guiding questions were used to facilitate discussion. Survey instruments were used to gather information about satisfaction with maternity care. Data for qualitative and quantitative analysis was aggregated using Rural Urban Commuting Area (RUCA) codes. Results. 14 groups with 47 total participants completed the survey and discussion. Participants were representative of a variety of Large Rural, Small Rural, and Isolated areas in Kansas as described by RUCA Code Four Category Classification. Survey results indicate that satisfaction with maternity care in participants’ home county was significantly higher in Small Rural and Isolated compared to Large Rural RUCA. Qualitative analysis results show positive experiences related to: doctor characteristics, relationship with doctor, doctor’s involvement with care, alternative labor options, and distance convenience. Negative experiences were related to: doctor bedside manner, doctor not there until delivery, and staff related complaints. Conclusions. Women in Small Rural and Isolated RUCA codes appear to be more satisfied with care contrary to previous study findings

Chemostratigraphy of Neoproterozoic carbonates: implications for 'blind dating'

The delta C-13(carb) and Sr-87/Sr-86 secular variations in Neoproteozoic seawater have been used for the purpose of 'isotope stratigraphy' but there are a number of problems that can preclude its routine use. In particular, it cannot be used with confidence for 'blind dating'. The compilation of isotopic data on carbonate rocks reveals a high level of inconsistency between various carbon isotope age curves constructed for Neoproteozoic seawater, caused by a relatively high frequency of both global and local delta C-13(carb) fluctuations combined with few reliable age determinations. Further complication is caused by the unresolved problem as to whether two or four glaciations, and associated negative delta C-13(carb) excursions, can be reliably documented. Carbon isotope stratigraphy cannot be used alone for geological correlation and 'blind dating'. Strontium isotope stratigraphy is a more reliable and precise tool for stratigraphic correlations and indirect age determinations. Combining strontium and carbon isotope stratigraphy, several discrete ages within the 590-544 Myr interval, and two age-groups at 660-610 and 740-690 Myr can be resolved

Induced four fold anisotropy and bias in compensated NiFe/FeMn double layers

A vector spin model is used to show how frustrations within a multisublattice antiferromagnet such as FeMn can lead to four-fold magnetic anisotropies acting on an exchange coupled ferromagnetic film. Possibilities for the existence of exchange bias are examined and shown to exist for the case of weak chemical disorder at the interface in an otherwise perfect structure. A sensitive dependence on interlayer exchange is found for anisotropies acting on the ferromagnet through the exchange coupling, and we show that a wide range of anisotropies can appear even for a perfect crystalline structure with an ideally flat interface.Comment: 7 pages, 7 figure

Cavity QED and quantum information processing with "hot" trapped atoms

We propose a method to implement cavity QED and quantum information processing in high-Q cavities with a single trapped but non-localized atom. The system is beyond the Lamb-Dick limit due to the atomic thermal motion. Our method is based on adiabatic passages, which make the relevant dynamics insensitive to the randomness of the atom position with an appropriate interaction configuration. The validity of this method is demonstrated from both approximate analytical calculations and exact numerical simulations. We also discuss various applications of this method based on the current experimental technology.Comment: 14 pages, 8 figures, Revte

Keeping it in the family: Parental influences on young people's attitudes to police

Prior research finds young people are less satisfied with police than their older counterparts. Despite this, our understanding of youth attitudes to police is limited, as most research has focused on adult attitudes to police. This study adds to our understanding by examining the influence of parent–child dynamics on youth attitudes to police. We predict that youth attitudes to police will be influenced by their parents’ attitudes. A survey of 540 school students in South East Queensland reveals that perceived parental attitudes to police are associated with youth attitudes to police. However, this effect is partially mediated by maternal, but not paternal attachment. These findings suggest that youth attitudes to police are not simply influenced by contact with police and delinquency, but that familial context is important. Consequently, our theoretical understanding of youth attitudes to police must move beyond a focus upon police contact and delinquency