212 research outputs found

    Behaviour and design of duplex stainless steel bolted connections failing in block shear

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    Duplex stainless steel (DSS) is an emerging construction material for structural engineering, which is featured with high mechanical strength and superior corrosion resistance. Compared with considerable research on DSS structural members, available research is relatively limited for structural joints/connections between these members. In line with this concern, this paper presents a comprehensive experimental and numerical study of duplex stainless steel bolted connections (DSSBCs), focusing on the behaviour and design related to block shear failure. Eleven specimens are tested to investigate the effect of different bolt arrangements on the block shear behaviour. Furthermore, a detailed numerical study was performed as a supplement to the experimental tests, where the anisotropic mechanical properties of DSS are considered in the finite element modelling. Based on the test and analysis results, it is found that the block shear failure mode of DSSBCs resembles that of carbon steel bolted connections, which can be characterised as necking of the tensile section and yielding of the shear sections. Using the experimental and numerical data obtained in this and previous studies, the applicability of various block shear design methods to stainless steel bolted connections is assessed. An updated design method is proposed for predicting the block shear capacity of duplex and austenitic stainless steel bolted connections. A proper partial safety factor/resistance factor is suggested for the proposed method based on the results of reliability analyses

    Bearing and tearout of austenitic and duplex stainless steel bolted connections

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    Due to the unique material characteristics of stainless steel, the bearing and tearout behaviour of stainless steel bolted connections can be different from that of carbon steel bolted connections. Such difference has been gradually recognised in recent design provisions for stainless steel structures. However, it is noteworthy that the existing design methods were mainly developed for austenitic and ferritic stainless steel bolted connections. Their applicability to duplex stainless steel bolted connections is questionable. Moreover, comparing to the bearing failure of stainless steel connections, less attention has been paid to the tearout failure, as well as the combined bearing and tearout failure in multi-bolt connections. To fill these gaps, an experimental and numerical study is carried out on the bearing/tearout behaviour and design of stainless steel bolted connections. The experimental programme includes 22 connection specimens with either single-bolt or multi-bolt configurations, made of austenitic or duplex stainless steel. The experimental tests are supplemented by a comprehensive numerical parametric study with more than 200 individual models, performed based on a validated finite element modelling technique. The obtained test and numerical results are used to assess the effects of different design parameters, as well as the applicability of existing design methods. It is concluded that the ultimate bearing/tearout resistances of austenitic and duplex connections are not simply proportionate to the ultimate strengths of the two materials. Given the same geometric design, the bearing resistance of a duplex connection is considerably higher than that of an austenitic connection, despite the similar ultimate strengths of the two materials. This difference in bearing performance is attributed to the different strain-hardening characteristics of austenitic and duplex materials, as well as the premature shear cracking in austenitic connections that leads to insufficiently developed strain-hardening. In comparison, the tearout resistances of austenitic and duplex connections with the same geometry are much closer, since the smaller end distance leads to more uniform deformations and more completely developed strain-hardening. Moreover, the combined bearing and tearout resistance of multi-bolt connections is found to be lower than the sum of the respective resistances of individual bolts. Finally, an updated design method is proposed that can accurately predict the bearing/tearout resistance of both austenitic and duplex stainless steel bolted connections. Proper partial factors are determined for the proposed method based on a reliability analysis

    Multi-Dimensional Simulations of Pair-Instability Supernovae

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    We present preliminary results from multidimensional numerical studies of pair instability supernova (PSN), studying the fluid instabilities that occur in multiple spatial dimensions. We use the new radiation-hydrodynamics code, CASTRO, and introduce a new mapping procedure that defines the initial conditions for the multidimensional runs in such a way that conservation of physical quantities is guaranteed at any level of resolution.Comment: Accepted for publication in Computer Physics Communications. 3 pages. 2 fig

    Aerodynamic Shape Optimization of a NACA0018 Airfoil Using Adjoint Method and Gradient-Based Optimizer

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    The purpose of this study is to demonstrate the suitability and efficacy of the adjoint method on the aerodynamic shape optimization on a simple symmetrical airfoil NACA0018 at low Reynolds number for wind turbine application. The adjoint method has been used in many pressure-based numerical simulations with various degrees of success leading to optimized geometries in their respective uses. ANSYS Fluent code was used in this simulation. Lift to drag ratio was defined as the observables for which adjoint sensitivities were formulated. The objective function of the optimization was set to maximize the lift to drag ratio of the airfoil by 20%. The optimization regime showed significant increase in lift and drag ratio from the initial baseline NACA0018 value of 0.0211 up to 3.66 for the optimal NACAOpt. The results demonstrate the potential of the adjoint solver paired together with the gradient-based optimizer to improve the geometry for shape optimization in many CFD applications

    Performance Enhancement of VAWT using Diffuser for Energy Extraction from Cooling Tower Exhaust Air

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    Renewable energy generation need to be accelerated to battle climate change and depletion of fossil fuel resources. Innovation to design wind recovery system which are efficient is vital to contribute green energy production. Many advancements in vertical axis wind turbines (VAWT) were made over the years however, it is still not as efficient as conventional turbines, and some countries does not have the luxury of strong consistent wind throughout the year. Therefore, this study focuses on extracting wind energy from unnatural sources, specifically for cooling tower exhaust air energy recovery. In this study, cycloidal diffuser with different shroud lengths was used to study the performance of a 3-bladed H-Darrieus VAWT (HDWT) with S-1046 airfoils under accelerated wind conditions in a 3-dimensional numerical study using shear stress transport k-ω turbulence model. The cycloidal diffuser with shroud length of 0.48D increased the HDWT power coefficient by 26.66% compared to the bare HDWT at tip speed ratio of 2.0. Aerodynamics around the energy extractor system was also discussed and this investigation has provided good understanding of the flow behaviour of the wind augmented HDWT under cooling tower exhaust air

    Full Counting Statistics of Superconductor--Normal-Metal Heterostructures

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    The article develops a powerful theoretical tool to obtain the full counting statistics. By a slight extension of the standard Keldysh method we can access immediately all correlation functions of the current operator. Embedded in a quantum generalization of the circuit theory of electronic transport, we are able to study the full counting statistics of a large class of two-terminal contacts and multi-terminal structures, containing superconductors and normal metals as elements. The practical use of the method is demonstrated in many examples.Comment: 35 pages, contribution to "Quantum Noise", ed. by Yu.V. Nazarov and Ya.M. Blanter, minor changes in text, references adde

    Measurement of finite-frequency current statistics in a single-electron transistor

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    Electron transport in nano-scale structures is strongly influenced by the Coulomb interaction which gives rise to correlations in the stream of charges and leaves clear fingerprints in the fluctuations of the electrical current. A complete understanding of the underlying physical processes requires measurements of the electrical fluctuations on all time and frequency scales, but experiments have so far been restricted to fixed frequency ranges as broadband detection of current fluctuations is an inherently difficult experimental procedure. Here we demonstrate that the electrical fluctuations in a single electron transistor (SET) can be accurately measured on all relevant frequencies using a nearby quantum point contact for on-chip real-time detection of the current pulses in the SET. We have directly measured the frequency-dependent current statistics and hereby fully characterized the fundamental tunneling processes in the SET. Our experiment paves the way for future investigations of interaction and coherence induced correlation effects in quantum transport.Comment: 7 pages, 3 figures, published in Nature Communications (open access

    Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells

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    <p>Abstract</p> <p>Background</p> <p>Previously we reported extensive gene expression reprogramming during epithelial to mesenchymal transition (EMT) of primary prostate cells. Here we investigated the hypothesis that specific histone and DNA methylations are involved in coordination of gene expression during EMT.</p> <p>Results</p> <p>Genome-wide profiling of histone methylations (H3K4me3 and H3K27me3) and DNA methylation (DNAMe) was applied to three cell lines at different stages of a stepwise prostate cell model involving EMT and subsequent accumulation of malignant features. Integrated analyses of epigenetic promoter modifications and gene expression changes revealed strong correlations between the dynamic changes of histone methylations and gene expression. DNA methylation was weaker associated with global gene repression, but strongly correlated to gene silencing when genes co-modified by H3K4me3 were excluded. For genes labeled with multiple epigenetic marks in their promoters, the level of transcription was associated with the net signal intensity of the activating mark H3K4me3 minus the repressive marks H3K27me3 or DNAMe, indicating that the effect on gene expression of bivalent marks (H3K4/K27me3 or H3K4me3/DNAMe) depends on relative modification intensities. Sets of genes, including epithelial cell junction and EMT associated fibroblast growth factor receptor genes, showed corresponding changes concerning epigenetic modifications and gene expression during EMT.</p> <p>Conclusions</p> <p>This work presents the first blueprint of epigenetic modifications in an epithelial cell line and the progeny that underwent EMT and shows that specific histone methylations are extensively involved in gene expression reprogramming during EMT and subsequent accumulation of malignant features. The observation that transcription activity of bivalently marked genes depends on the relative labeling intensity of individual marks provides a new view of quantitative regulation of epigenetic modification.</p

    Genome-Wide Profiling of Histone H3 Lysine 4 and Lysine 27 Trimethylation Reveals an Epigenetic Signature in Prostate Carcinogenesis

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    BACKGROUND: Increasing evidence implicates the critical roles of epigenetic regulation in cancer. Very recent reports indicate that global gene silencing in cancer is associated with specific epigenetic modifications. However, the relationship between epigenetic switches and more dynamic patterns of gene activation and repression has remained largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: Genome-wide profiling of the trimethylation of histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3) was performed using chromatin immunoprecipitation coupled with whole genome promoter microarray (ChIP-chip) techniques. Comparison of the ChIP-chip data and microarray gene expression data revealed that loss and/or gain of H3K4me3 and/or H3K27me3 were strongly associated with differential gene expression, including microRNA expression, between prostate cancer and primary cells. The most common switches were gain or loss of H3K27me3 coupled with low effect on gene expression. The least prevalent switches were between H3K4me3 and H3K27me3 coupled with much higher fractions of activated and silenced genes. Promoter patterns of H3K4me3 and H3K27me3 corresponded strongly with coordinated expression changes of regulatory gene modules, such as HOX and microRNA genes, and structural gene modules, such as desmosome and gap junction genes. A number of epigenetically switched oncogenes and tumor suppressor genes were found overexpressed and underexpressed accordingly in prostate cancer cells. CONCLUSIONS/SIGNIFICANCE: This work offers a dynamic picture of epigenetic switches in carcinogenesis and contributes to an overall understanding of coordinated regulation of gene expression in cancer. Our data indicate an H3K4me3/H3K27me3 epigenetic signature of prostate carcinogenesis

    On the Chemical Origin of the Gap Bowing in (GaAs)1−xGe2x Alloys: A Combined DFT–QSGW Study

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    Motivated by the research and analysis of new materials for photovoltaics and by the possibility of tailoring their optical properties for improved solar energy conversion, we have focused our attention on the (GaAs)1−xGe2x series of alloys. We have investigated the structural properties of some (GaAs)1−xGe2x compounds within the local-density approximation to density-functional theory, and their optical properties within the Quasiparticle Self-consistent GW approximation. The QSGW results confirm the experimental evidence of asymmetric bandgap bowing. It is explained in terms of violations of the octet rule, as well as in terms of the order–disorder phase transition
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