Bioactive compounds of plum mango (Bouea macrophylla Griffith)

The fruit of Bouea macrophylla referred as Plum mango or Gandaria is a popular seasonal fruit, which is widely consumed in the Malay subcontinent. There is ample of traditional knowledge available among the locals on the use of leaves, bark, fruits and seeds of this plant. However, very limited research information and scientific report is available on their composition, phytochemicals or on the bioactive compounds. In the present chapter, we have aimed towards comprehensively providing information on nutritional value, functional qualities, health promoting bioactive compounds and volatile constituents of this underutilized fruit

Overview of diagnosis and management of paediatric headache. Part I: diagnosis

Headache is the most common somatic complaint in children and adolescents. The evaluation should include detailed history of children and adolescents completed by detailed general and neurological examinations. Moreover, the possible role of psychological factors, life events and excessively stressful lifestyle in influencing recurrent headache need to be checked. The choice of laboratory tests rests on the differential diagnosis suggested by the history, the character and temporal pattern of the headache, and the physical and neurological examinations. Subjects who have any signs or symptoms of focal/progressive neurological disturbances should be investigated by neuroimaging techniques. The electroencephalogram and other neurophysiological examinations are of limited value in the routine evaluation of headaches. In a primary headache disorder, headache itself is the illness and headache is not attributed to any other disorder (e.g. migraine, tension-type headache, cluster headache and other trigeminal autonomic cephalgias). In secondary headache disorders, headache is the symptom of identifiable structural, metabolic or other abnormality. Red flags include the first or worst headache ever in the life, recent headache onset, increasing severity or frequency, occipital location, awakening from sleep because of headache, headache occurring exclusively in the morning associated with severe vomiting and headache associated with straining. Thus, the differential diagnosis between primary and secondary headaches rests mainly on clinical criteria. A thorough evaluation of headache in children and adolescents is necessary to make the correct diagnosis and initiate treatment, bearing in mind that children with headache are more likely to experience psychosocial adversity and to grow up with an excess of both headache and other physical and psychiatric symptoms and this creates an important healthcare problem for their future life

Surveillance in the Name of Governance: Aadhaar as a Fix for Leaking Systems in India

Many jurisdictions are employing biometric technologies to collect data about and verify the identities of social assistance recipients, with fraud prevention and cost savings serving as common justifications for doing so. This chapter explores the practices of building the infrastructure to monitor welfare beneficiaries, many of whom are vulnerable or marginalised populations. To do so, the chapter examines the Aadhaar system in India, which has issued over one billion unique identification numbers since being launched in 2010. The analysis illustrates a one-way expectation of knowledge and transparency (i.e., for citizens to disclose in order to access services), drawing attention to how nationalist agendas and forms of inequality inform who is subject to the state’s terms and conditions. In doing so, it considers how these forms of surveillance evince broader shifts in which state and non-state actors rely on knowledge to regulate subjects

IL-12p40/IL-10 Producing preCD8α/Clec9A+Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection

Infection by Listeria monocytogenes (Lm) causes serious sepsis and meningitis leading to mortality in neonates. This work explored the ability of CD11chighlineage DCs to induce CD8+T-cell immune protection against Lm in mice before 7 days of life, a period symbolized by the absence of murine IL-12p70-producing CD11chighCD8α+dendritic cells (DCs). We characterized a dominant functional Batf3-dependent precursor of CD11chighDCs that is Clec9A+CD205+CD24+but CD8α-at 3 days of life. After Lm-OVA infection, these pre-DCs that cross-present Ag display the unique ability to produce high levels of IL-12p40 (not IL-12p70 nor IL-23), which enhances OVA-specific CD8+T cell response, and regulatory IL-10 that limits OVA-specific CD8+T cell response. Targeting these neonatal pre-DCs for the first time with a single treatment of anti-Clec9A-OVA antibody in combination with a DC activating agent such as poly(I:C) increased the protection against later exposure to the Lm-OVA strain. Poly(I:C) was shown to induce IL-12p40 production, but not IL-10 by neonatal pre-DCs. In conclusion, we identified a new biologically active precursor of Clec9A+CD8α-DCs, endowed with regulatory properties in early life that represents a valuable target to augment memory responses to vaccines.SCOPUS: ar.jinfo:eu-repo/semantics/publishe