Kant, Morality, and Hell

In this paper I argue that, although Kant argues that morality is independent of God (and hence, agrees with the Euthyphro), and rejects Divine Command Theory (or Theological Voluntarism), he believes that all moral duties are also the commands of God, who is a moral being, and who is morally required to punish those who transgress the moral law: "God’s justice is the precise allocation of punishments and rewards in accordance with men’s good or bad behavior." However, since we lack a strict proof of God's existence, we can still fulfill our duties from the motive of duty. if we did know that God exists, then this would undermine our pure moral motivation to do our duty, since we would have an even stronger interest in pleasing God through our good conduct. The effect of undermining our pure moral motivation would be to make us less eligible for divine reward, since God rewards us for doing our duty from the motive of duty

Higher accuracy protein Multiple Sequence Alignment by Stochastic Algorithm

Multiple Sequence Alignment gives insight into evolutionary, structural and functional relationships among the proteins. Here, a novel Protein Alignment by Stochastic Algorithm (PASA) is developed. Evolutionary operators of a genetic algorithm, namely, mutation and selection are utilized in combining the output of two most important sequence alignment programs and then developing an optimized new algorithm. Efficiency of protein alignments is evaluated in terms of Total Column score which is equal to the number of correctly aligned columns between a test alignment and the reference alignment divided by the total number of columns in the reference alignment. The PASA optimizer achieves, on an average, significant better alignment over the well known individual bioinformatics tools. This PASA is statistically the most accurate protein alignment method today. It can have potential applications in drug discovery processes in the biotechnology industry

Broadband dielectric response of CaCu3Ti4O12: From dc to the electronic transition regime

We report on phonon properties and electronic transitions in CaCu3Ti4O12, a material which reveals a colossal dielectric constant at room temperature without any ferroelectric transition. The results of far- and mid-infrared measurements are compared to those obtained by broadband dielectric and millimeter-wave spectroscopy on the same single crystal. The unusual temperature dependence of phonon eigenfrequencies, dampings and ionic plasma frequencies of low lying phonon modes are analyzed and discussed in detail. Electronic excitations below 4 eV are identified as transitions between full and empty hybridized oxygen-copper bands and between oxygen-copper and unoccupied Ti 3d bands. The unusually small band gap determined from the dc-conductivity (~200 meV) compares well with the optical results.Comment: 7 pages, 8 figure

Plasticity of Axial Identity among Somites: Cranial Somites Can Generate Vertebrae without Expressing Hox Genes Appropriate to the Trunk

AbstractClassic studies have shown that the presomitic mesoderm is already committed to a specific morphological fate, for example, the ability to generate a rib. Hox gene expression in the paraxial mesoderm has also been shown to be fixed early and not susceptible to modulation by an ectopic environment. This is in contrast to the plasticity of Hox expression in neuroectodermal derivatives. We reexamine here the potential of somites for morphological plasticity by transplanting the cranial (occipital) somites 1–4, that normally produce small contributions to the skull, to the trunk of avian embryos. Surprisingly, the transposed cranial somites are able to form reasonably normal vertebral anlage. In addition, the cranial somitic mesoderm produces intervertebral disks, structures not normally found in the skull. These somites are however unable to generate some elements of the vertebrae, such as the costal process. In contrast to the morphogenetic plasticity of the occipital somites, their characteristic inability to support survival of dorsal root ganglia was not significantly modified by posterior transplantation. Dorsal root ganglia initially developed and then degenerated with the same morphological stages as normally observed. In striking contrast to the plasticity of morphology, we found that all four members of the of the fourth paralogous group of Hox genes that are expressed endogenously at the level of the graft are not upregulated in the caudad-transposed cranial mesoderm. It therefore appears that genes other than those of the Hox family normally expressed at this axial level control the position-specific morphogenesis of ectopic vertebrae formed from cranial somites. In evolutionary terms, the present results imply that occipital somites that were incorporated into the “New Head” retain the ability to develop according to their original morphogenetic fate, into vertebrae

On accurate estimation of transverse stresses in multilayer laminates

New numerical algorithms are proposed for the accurate evaluation of transverse stresses in general composite and sandwich laminates. A set of higher-order theories with C0 isoparameteric finite elements and exact three-dimensional equilibrium equations are used. The integration of the equilibrium equations is carried out through exact surface fitting method, direct integration method and forward and central direct finite difference methods. Sixteen- and nine-noded quadrilateral Lagrangian elements with selective numerical integration techniques based on Gauss-Legendre product rules are used in the analysis. Validity of the present numerical techniques and the higher-order theories are demonstrated by comparing the present results with the available elasticity and other closed-form solutions for cross-ply, angle-ply and sandwich laminates. The exact surface fitting method is seen to give accurate estimate of the transverse stresses compared to other methods

Thermal buckling analysis of skew fibre-reinforced composite and sandwich plates using shear deformable finite element models

The paper considers the elastic buckling of skew fibre-reinforced composite and sandwich plates subjected to thermal loads. To the best of the authors' knowledge, there is no paper in the open literature on this subject and the present paper attempts to fill this gap. Two shear deformable finite element models, one based on first-order shear deformation theory and the other based on higher-order shear deformation theory, are employed to obtain thermal buckling solutions. Extensive numerical results are presented for both thin and thick laminated composite plates with various skew angles, lamination parameters and boundary conditions. A few results for skew sandwiches are obtained for various geometric parameters and skew angles. Results presented, not available so far, could be useful to designers and researchers who may use them as benchmark values to validate their numerical techniques and software for similar problems

A stress correction procedure for the analysis of inelastic frames under transient dynamic loads

This paper attempts to present an algorithm (as a set of conditions and equations) for the correction of stresses of both strain-hardening and perfectly-plastic materials, for the analysis of frames under transient dynamic loadings. The validity of the proposed conditions and equations is verified through numerical experiments

Calibration and validation of parking search time function

Large off-street car parks are traditionally modelled as self-standing traffic zones representing origins/destinations in standard network assignment models. However, such a treatment precludes the drivers from choosing alternative car parks as it assumes the car parks are their final destinations. This paper discusses the feasibility of bringing car park choice and the effects of capacity within a traditional network assignment model. The search time within car parks depends on the car park occupancy and can be represented by a flow-delay type function on the car park occupancy/capacity. This research calibrates the search-time function based on practically observed occupancy and search time at two city-centre car parks in Leeds, England. The analysis follows a simple fixed search-time method as well as a sophisticated variable search-time method. The results are validated against the observed occupancies at the car parks. A car park specific constant was introduced to account for the unobserved preference for a given type of parking facility. In a multiperiod assignment, when car park occupancies are passed on dynamically, both fixed and variable search-time approaches are seen as an improvement over the standard approach, with the variable search time outperforming the fixed time approach