Co-Creating Community-Based Solutions through Social Media in Estonia during the COVID-19 Pandemic

In this study, we aimed to explore and describe the prosocial behaviour of the community during the COVID-19 crisis in Estonia on Facebook, using mixed-method content analysis.This article focuses on the role of social media in co-creation in the context of the COVID-19 pandemic and the use of Facebook (FB) as a modern communication technology in times of crisis. Our goal was to learn how Facebook as a social media channel can be a tool and accelerator that allows people to find solutions to social problems in communities experiencing crises. The focus of the research is on finding solutions in co-creation for vulnerable target groups, including the elderly, people with disabilities, and other people who need support. This research expands on the role and potential of using FB as a communication platform to enhance co-creation.We used Kaun and Uldam’s (2018) model as a theoretical framework for this study. The study is characterised by a descriptive and exploratory research design. We studied the prosocial behaviour of the community on Facebook through a three-stage mixed method content analysis of existing data, including posts and comments on FB pages, using both quantitative (descriptive statistics) and qualitative (thematic analysis) data analysis methods. Our findings suggest that Facebook as a social media channel could be successfully utilised as a tool for sharing calls to action, activating citizens to co-create solutions, and disseminating results.Keywords: prosocial behaviour; co-creation; community support; Facebook; COVID-19

Koroonaviiruse omikrontüve vastane antikehade kaitse ja T-rakuline immuunvastus pärast BNT162b2-vaktsiini tõhustusdoosi saamist

Eesti Arst 2023; 102(2):11

N-glycan mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is an autoimmune disorder caused by the development of autoantibodies targeting different domains of ADAMTS13. Profiling studies have shown that residues R568, F592, R660, Y661, and Y665 within exosite-3 of the spacer domain provide an immunodominant region of ADAMTS13 for pathogenic autoantibodies that develop in patients with iTTP. Modification of these 5 core residues with the goal of reducing autoantibody binding revealed a significant tradeoff between autoantibody resistance and proteolytic activity. Here, we employed structural bioinformatics to identify a larger epitope landscape on the ADAMTS13 spacer domain. Models of spacer-antibody complexes predicted that residues R568, L591, F592, K608, M609, R636, L637, R639, R660, Y661, Y665, and L668 contribute to an expanded epitope within the spacer domain. Based on bioinformatics-guided predictions, we designed a panel of N-glycan insertions in this expanded epitope to reduce the binding of spacer domain autoantibodies. One N-glycan variant (NGLY3-ADAMTS13, containing a K608N substitution) showed strongly reduced reactivity with TTP patient sera (28%) as compared with WT-ADAMTS13 (100%). Insertion of an N-glycan at amino acid position 608 did not interfere with processing of von Willebrand factor, positioning the resulting NGLY3-ADAMTS13 variant as a potential novel therapeutic option for treatment of iTTP

Co-Creation and Enhanced Youth Participation in Local Decision-Making: The Perception of Public Sector Readiness

The reverted demographic pyramid makes youth a decreasing percentage of our increasingly ageing population, leaving youth groups with less power and chances to influence the future of public policies and services through established participation channels. There is a potential risk of losing the interests of broader, including less heard, youth groups in democratic decision-making and implementation. Research evidence shows that we need to broaden knowledge and accountability towards these groups by including them more in co-creation to secure their trust and meaningful policy impact. One major way to improve trust in the public sector is by enhancing the abilities of professionals, managers, politicians and NGOs to co-create public and individual values with youth groups for better services and solutions instead of acting and making decisions on their behalf. Also, cross-sector collaboration among institutional units or stakeholders from different sectors on a local scale is often required to enhance the value of services or local community decisions. This paper explores from a comparative perspective the readiness of the local governments for enhanced democratic participation and co-creation of public services and public value with youth. Based on document studies, interviews and cross-sectoral learning dialogues between engaged researchers, public sector and NGO representatives conducted in three countries – Sweden, Finland, and Estonia – the paper illustrates the current perceptions of public professionals and managers regarding their approach to co-creation with youth and the public

Sotsiaalse häkätoni juhis

CoSIE project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 77049

Estonian Vunimano I Hackathon collected interviews 05.-07.10.2018

This project CoSIE (Co-creation of Service Innovation in Europe) has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 770492.Estonian Vunkimano I Hackathon interviews collected 05-07.10.2018: interviews with hackathon teams, mentors and policy maker

The Expanded Endocannabinoid System Contributes to Metabolic and Body Mass Shifts in First-Episode Schizophrenia: A 5-Year Follow-Up Study

Alterations in the expanded endocannabinoid system (eECS) and cell membrane composition have been implicated in the pathophysiology of schizophrenia spectrum disorders. We enrolled 54 antipsychotic (AP)-naïve first-episode psychosis (FEP) patients and 58 controls and applied a targeted metabolomics approach followed by multivariate data analysis to investigate the profile changes in the serum levels of endocannabinoids: 2-arachidonoylglycerol (2-AG) and anandamide, endocannabinoids-like N-acylethanolamines (NAEs: linoleoylethanolamide, oleoylethanolamide, and palmitoylethanolamide), and their dominating lipid precursor’s phosphatidylcholines. Biomolecule profiles were measured at the onset of first-episode psychosis (FEP) and 0.6 years and 5.1 years after the initiation of AP treatment. The results indicated that FEP might be characterized by elevated concentrations of NAEs and by decreased 2-AG levels. At this stage of the disease, the NAE-mediated upregulation of peroxisome proliferator-activated receptors (PPARs) manifested themselves in energy expenditure. A 5-year disease progression and AP treatment adverse effects led to a robust increase in 2-AG levels, which contributed to strengthened cannabinoid (CB1) receptor-mediated effects, which manifested in obesity. Dynamic 2-AG, NAEs, and their precursors in terms of phosphatidylcholines are relevant to the description of the metabolic shifts resulting from the altered eECS function during and after FEP