Correction to: Does transcranial direct current stimulation improve functional locomotion in people with Parkinson’s disease? A systematic review and meta-analysis

In the original article [1], we mentioned that some study characteristics of the article by Dagan and colleagues [2] were unavailable. However, we realized that the authors provided the relevant information in their supplementary file. As such, we added participant characteristics (i.e., age = 68.8 ± 6.8, gender = 17 M, 3 F, PD duration = 9.0 ± 5.7, and UPDRS Part III at baseline = Total 39.7 ± 14.6) to Table 1, stimulation parameters (i.e., intensity = 3 mA, duration = 20 min, areas = 3 cm2) to Table 2, and methodological quality assessments (i.e., allocation concealment = 1 and Total score = 9) to Table 3. Based on the new information, we updated Fig. 2 with the corrected selection bias and performance bias results. Finally, we confirmed that these corrections did not change the meta-analytic findings in the original article

Enhanced production of tropane alkaloids in transgenic Scopolia parviflora hairy root cultures over-expressing putrescine N-methyl transferase (PMT) and hyoscyamine-6β-hydroxylase (H6H)

Scopolia parviflora adventitious roots were metabolically engineered by co-expression of the two gene putrescine N-methyl transferase (PMT) and hyoscyamine-6β-hydroxylase (H6H) cDNAs with the aid of Agrobacterium rhizogenes. The transformed roots developed into morphologically distinct S. parviflora PMT1 (SpPMT1), S. parviflora PMT1 (SpPMT2), and S. parviflora H6H (SpH6H) transgenic hairy root lines. Consequent to the introduction of these key enzyme genes, the production of the alkaloids hyoscyamine and scopolamine was enhanced. Among the transgenic hairy root lines, SpPMT2 line possessed the highest growth index. The treatment of transgenic hairy roots with growth regulators further enhanced the production of scopolamine. Thus, the results suggest that PMT1, PMT2, and H6H genes may not only be involved in the metabolic regulation of alkaloid production but also that these genes may play a role in the root development

Tibetan sheep are better able to cope with low energy intake than Small-tailed Han sheep due to lower maintenance energy requirements and higher nutrient digestibilities

Tibetan sheep are indigenous to the Qinghai-Tibetan Plateau (QTP) and are well-adapted to and even thrive under the harsh alpine conditions. Small-tailed Han sheep were introduced to the plateau because of their high prolificacy and are maintained mainly in feedlots. Because of their different backgrounds, we hypothesised that Tibetan and Small-tailed Han sheep would differ in their utilization of energy intake and predicted that Tibetan sheep would cope better with low energy intake than Small-tailed Han sheep. To test this prediction, we determined nutrient digestibilities, energy requirements for maintenance and blood metabolite and hormone concentrations involved in energy metabolism in these breeds. Sheep of each breed (n = 24 of each, all wethers and 1.5 years of age) were distributed randomly into one of four groups and offered ad libitum diets of different digestible energy (DE) densities: 8.21, 9.33, 10.45 and 11.57 MJ DE/kg Dry matter (DM). Following 42 d of measuring feed intake, a 1-week digestion and metabolism experiment was done. DM intakes did not differ between breeds nor among treatments but, by design, DE intake increased linearly in both breeds as dietary energy level increased (P < 0.001). The average daily gain (ADG) was significantly greater in the Tibetan than Small-tailed Han sheep (P = 0.003) and increased linearly in both breeds (P < 0.001). In addition, from the regression analysis of ADG on DE intake, daily DE maintenance requirements were lower for Tibetan than for Small-tailed Han sheep (0.41 vs 0.50 MJ/BW0.75, P < 0.05). The DE and metabolizable energy (ME) digestibilities were higher in the Tibetan than Small-tailed Han sheep (P < 0.001) and increased linearly as the energy level increased in the diet (P < 0.001). At the lowest energy treatment, Tibetan sheep when compared with Small-tailed Han sheep, had: 1) higher serum glucose and glucagon, but lower insulin concentrations (P < 0.05), which indicated a higher capacity for gluconeogenesis and ability to regulate glucose metabolism; and 2) higher non-esterified fatty acids (NEFA) and lower very low density lipoprotein (VLDL) and triglyceride (TG) concentrations (P < 0.05), which indicated a higher capacity for NEFA oxidation but lower ability for triglyceride (TG) synthesis. We concluded that our prediction was supported as these differences between breeds conferred an advantage for Tibetan over Small-tailed Han sheep to cope better with low energy diets

A BGG-type resolution for tensor modules over general linear superalgebra

We construct a Bernstein-Gelfand-Gelfand type resolution in terms of direct sums of Kac modules for the finite-dimensional irreducible tensor representations of the general linear superalgebra. As a consequence it follows that the unique maximal submodule of a corresponding reducible Kac module is generated by its proper singular vector.Comment: 11pages, LaTeX forma

Dynamic characteristics of flow meters for fuel consumption measurement in ships

The dynamic characteristics of various flow meters for fuel consumption measurement aboard shipswere evaluated. The flow rate was measured using the Korea Research Institute of Standards and Science (KRISS) oil flow standard system using K-oil(density : 0.804 g/cm3, viscosity : 3.679 cSt), which has similar fluid properties as diesel oil. The flow meters were tested in a test bed that simulated the vibration conditions in ships. The vibration conditions were established in accordance to vibration standard IEC 60068-2-6 as follows: a±0.7g acceleration and 30 Hz frequency. The K-factors (mL/pulse) of various flow meters (PD meter, turbine flow meter, Coriolis flow meter, and ultrasonic flow meter) were obtained for various flow rates (60 L/h ~ 300 L/h). The PD meter, Coriolis flow meter, and ultrasonic flow meter were found to have almost constant Kfactors according to the flow rates. However, the K-factor of the turbine flow meter was reduced at a low flow rate owing to bearing friction in the turbine blade. The flow rate errors of the PD meter, Coriolis flow meter, and ultrasonic flow meter were found to be under ±0.5 % with and without vibration. However, the flow rate error of the turbine flow meter was approximately -4.3 % at a low flow rate (60 L/h) owing to the friction effect. The Coriolis flow meter had the lowest flow rate error (< 0.1%) according to the flow rate. The vibration influenced the flow rate error of the Coriolis flow meter at high flow rates owing to its measuring principle. However, the difference in flow rate errors was a negligible value (0.05 %) with and without vibration. Therefore, we confirmed that the PD meter, turbine meter, Coriolis flow meter and ultrasonic flow meter could be used for measuring flow rates in ships with a ±0.5 % flow rate error.Papers presented at the 13th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Portoroz, Slovenia on 17-19 July 2017 .International centre for heat and mass transfer.American society of thermal and fluids engineers

U(1) Gauge Field of the Kaluza-Klein Theory in the Presence of Branes

We investigate the zero mode dimensional reduction of the Kaluza-Klein unifications in the presence of a single brane in the infinite extra dimension. We treat the brane as fixed, not a dynamical object, and do not require the orbifold symmetry. It seems that, contrary to the standard Kaluza-Klein models, the 4D effective action is no longer invariant under the U(1) gauge transformations due to the explicit breaking of isometries in the extra dimension by the brane. Surprisingly, however, the linearized perturbation analysis around the RS vacuum shows that the Kaluza-Klein gauge field does possess the U(1) gauge symmetry at the linear level. In addition, the graviscalar also behaves differently from the 4D point of view. Some physical implications of our results are also discussed.Comment: 10 pages, revtex, no figure, version to appear in Phys. Rev. D, possible caveats of our results due to the zero mode ansatz we used are explained in more detai

Gemcitabine-Based Neoadjuvant Treatment in Borderline Resectable Pancreatic Ductal Adenocarcinoma: A Meta-Analysis of Individual Patient Data

Background: Non-randomized studies have investigated multi-agent gemcitabinebased neo-adjuvant therapies (GEM-NAT) in borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC). Treatment sequencing and specific elements of neoadjuvant treatment are still under investigation. The present meta-analysis aims to assess the effectiveness of GEM-NAT on overall survival (OS) in BR-PDAC. Patients and Methods: A meta-analysis of individual participant data (IPD) on GEMNAT for BR-PDAC were performed. The primary outcome was OS after treatment with GEM-based chemotherapy. In the Individual Patient Data analysis data were reappraised and confirmed as BR-PDAC on provided radiological data. Results: Six studies investigating GEM-NAT were included in the IPD metanalysis. The IPD metanalysis was conducted on 271 patients who received GEM-NAT. Pooled median patient-level OS was 22.2 months (95%CI 19.1–25.2). R0 rates ranged between 81 and 95% (I 2 = 0%, p = 0.64), respectively. Median OS was 27.8 months (95%CI 23.9–31.6) in the patients who received NAT-GEM followed by resection compared to 15.4 months (95%CI 12.3–18.4) for NAT-GEM without resection and 13.0 months (95%CI 7.4–18.5) in the group of patients who received upfront surgery (p < 0.0001). R0 rates ranged between 81 and 95% (I 2 = 0%, p = 0.64), respectively. Overall survival in the R0 group was 29.3 months (95% CI 24.3–34.2) vs. 16.2 months (95% CI 7·9–24.5) in the R1 group (p = 0·001). Conclusions: The present study is the first meta-analysis combining IPD from a number of international centers with BR-PDAC in a cohort that underwent multi-agent gemcitabine neoadjuvant therapy (GEM-NAT) before surgery. GEM-NAT followed by surgical resection improve sur

Magnetic Flux of EUV Arcade and Dimming Regions as a Relevant Parameter for Early Diagnostics of Solar Eruptions - Sources of Non-Recurrent Geomagnetic Storms and Forbush Decreases

This study aims at the early diagnostics of geoeffectiveness of coronal mass ejections (CMEs) from quantitative parameters of the accompanying EUV dimming and arcade events. We study events of the 23th solar cycle, in which major non-recurrent geomagnetic storms (GMS) with Dst <-100 nT are sufficiently reliably identified with their solar sources in the central part of the disk. Using the SOHO/EIT 195 A images and MDI magnetograms, we select significant dimming and arcade areas and calculate summarized unsigned magnetic fluxes in these regions at the photospheric level. The high relevance of this eruption parameter is displayed by its pronounced correlation with the Forbush decrease (FD) magnitude, which, unlike GMSs, does not depend on the sign of the Bz component but is determined by global characteristics of ICMEs. Correlations with the same magnetic flux in the solar source region are found for the GMS intensity (at the first step, without taking into account factors determining the Bz component near the Earth), as well as for the temporal intervals between the solar eruptions and the GMS onset and peak times. The larger the magnetic flux, the stronger the FD and GMS intensities are and the shorter the ICME transit time is. The revealed correlations indicate that the main quantitative characteristics of major non-recurrent space weather disturbances are largely determined by measurable parameters of solar eruptions, in particular, by the magnetic flux in dimming areas and arcades, and can be tentatively estimated in advance with a lead time from 1 to 4 days. For GMS intensity, the revealed dependencies allow one to estimate a possible value, which can be expected if the Bz component is negative.Comment: 27 pages, 5 figures. Accepted for publication in Solar Physic

No ghost state of Gauss-Bonnet interaction in warped backgrounds

A general solution to the Einstein field equations with Gauss-Bonnet(GB) term in the $AdS_5$ bulk background implies that the GB coupling $\alpha$ can take either sign (+ or -), though a positive $\alpha$ will be more meaningful. By considering linearized gravity with the GB term in the Randall-Sundrum(RS) a singular 3-brane model, we study the gravitational interactions between matter sources localized on the brane. With a correctly defined boundary condition on the brane, we find a smooth behavior of graviton propagator and hence the zero-mode solution as a 4d massless graviton localized on the brane with correct momentum and tensor structures. The coupling $\alpha$ modifies the graviton propagators both on the brane and in the bulk. The issue on ghost state of the GB term is resolved, and we find that there is no real ghost (negative norm) state of the GB term in the RS single brane picture. The latter condition leads to a consistency in the coupling between the brane matter and the bulk gravity. We also elucidate about the possibilities for behavior of a test particle on the brane and in the bulk.Comment: 24 pages, LaTex, minor correction to discussion, replaced with NPB versio