Studies on the Linear Antiferromagnets : Magnetic Susceptibilities of Cupric Quinone Complex Salts at Low Temperatures

The magnetic susceptibilities of three Cu quinone complex salts were measured at low temperatures. These salts, Cu-Q-H, Cu-Q-Cl and Cu-Q-Br, are considered to have structure of magnetic one dimensional lattice. Cu-Q-H is obtained in the form of stick-like colloid whose length is shorter than a few thousand A. Some characteristics of the antiferromagnetic linear chain were found in Cu-Q-H. At the lowest temperatures, the end effect and the odd or even number effect were examined. The length of the chain of Cu-Q-H is estimated to have the number of Cu^ ions more than 9. The super-exchange interaction in a chain of each salt passes through the intervening quinone-molecule. The coupling constant J between nearest neighboured Cu^ ions in Cu-Q-H was estimated to be between -14k and -24k. The large J\u27s of three salts may be attributed to the superexchange interaction through the quinone-molecule

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Chromosome aberrations in lymphocytes of individuals living in high background radiation areas of Ramsar-Iran

The Talesh Mahalleh area in Ramsar has the highest terrestrial radiation potential effective public dose levels in Iran. The high background radiation of this area is mainly due to hot springs with high concentrations of radium-226 and its decay products, which flow into the surrounding areas causing a high potential for public exposure. To identify the dose-dependent increase of dicentrics and ring chromosomes in lymphocytes of the residents in the high background radiation area (HBRA) of Ramsar, personal dose monitoring and cytogenetic investigation were performed for 15 elderly housekeeping women living in Talesh Mahalleh and 10 matched elderly women in the nearby control area (CA) of Katalom where lifestyle and living circumstances of the residents are similar to those of the HBRA. All the subjects in our study are nonsmokers. The age ranges were 50-63 (average of 55.6 +- 4.4) years in HBRA and 50-62 (average of 53.3+- 4.9) years in the CA. To obtain accurate data in quantifying dicentric and ring chromosomes, we carried out a cytogenetic study using advanced techniques with improved recovery of metaphase. Dicentric and ring chromosome were scored for more than 2000 cells per individual under a microscope equipped with an automated stage. The exposed radiation dose of each individual in the HBRA and CA was estimated from the dose measured by an electronic pocket dosimeter (EPDTM) and a Luxel badge. The results of the analysis of unstable chromosome aberrations found in the residents in the HBRA and the control areas will be presented.日本放射線影響学会第48回大会第1回アジア放射線研究会

A CASE OF YOUNG WOMAN WITH EARLY OBLITERATION OF THE SUTURES OF THE SKULL

Authors have had to perform autopsy on young woman with early obliteration of the sutures of the skull, and have added the various considerations suggested by literatures concernd with early obliteration of the sutures

Curcumin-Loaded Liposome Preparation in Ultrasound Environment under Pressurized Carbon Dioxide

Curcumin-loaded liposomes were prepared using a supercritical carbon dioxide (SCCO2)–ultrasound environment system. The experiments were performed at temperatures of 40–70 °C and pressures of 10–25 MPa in a batch system with ultrasonication for 60 min. Transmission electron microscopy (TEM) images revealed liposome products with spherical morphologies and diameters of <100 nm. Dynamic light scattering (DLS) analysis indicated that the curcumin-loaded liposome nanosuspension exhibited good stability. Changing the operating conditions influenced the amount of liposome-encapsulated curcumin; as the operating temperature or pressure increased, the diameter of the liposome products and the amount of liposome-encapsulated curcumin increased and decreased, respectively. Herein, we described an innovative and practical organic-solvent-free method for generating liposomes from phospholipids