398 research outputs found
First occurrence of the invasive alien species Polydora cornuta Bosc, 1802 (Polychaeta: Spionidae) on the coast of Greece (Elefsis Bay; Aegean Sea)
The present study reports on the occurrence of two specimens of the alien species Polydora cornutaBosc, 1802, in Elefsis Bay, the Saronikos Gulf (Aegean Sea, eastern Mediterranean). This is the firstrecord of this invasive alien species on the coast of Greece and the second report in the eastern MediterraneanSea after its first finding in Izmir Bay (on the Turkish Aegean coast). This finding enhances its distributionalpattern within the Mediterranea
Quantification of Plasma and Urine Thymidine and 2'-Deoxyuridine by LC-MS/MS for the Pharmacodynamic Evaluation of Erythrocyte Encapsulated Thymidine Phosphorylase in Patients with Mitochondrial Neurogastrointestinal Encephalomyopathy.
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare disorder caused by mutations in TYMP, leading to a deficiency in thymidine phosphorylase and a subsequent systemic accumulation of thymidine and 2'-deoxyuridine. Erythrocyte-encapsulated thymidine phosphorylase (EE-TP) is under clinical development as an enzyme replacement therapy for MNGIE. Bioanalytical methods were developed according to regulatory guidelines for the quantification of thymidine and 2'-deoxyuridine in plasma and urine using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for supporting the pharmacodynamic evaluation of EE-TP. Samples were deproteinized with 5% perchloric acid (v/v) and the supernatants analyzed using a Hypercarb column (30 × 2.1 mm, 3 µm), with mobile phases of 0.1% formic acid in methanol and 0.1% formic acid in deionized water. Detection was conducted using an ion-spray interface running in positive mode. Isotopically labelled thymidine and 2'-deoxyuridine were used as internal standards. Calibration curves for both metabolites showed linearity (r > 0.99) in the concentration ranges of 10-10,000 ng/mL for plasma, and 1-50 µg/mL for urine, with method analytical performances within the acceptable criteria for quality control samples. The plasma method was successfully applied to the diagnosis of two patients with MNGIE and the quantification of plasma metabolites in three patients treated with EE-TP
Generalized ID-based blind signatures from bilinear pairings
Blind signature schemes provide the feature that a user is able to get a signature without giving the actual message to the signer. Recently a number of ID-based blind signatures have been proposed. In this paper, we introduce the concept of generalized ID-based blind signatures based on ElGamal signature variants. We obtain several new ID-based blind signatures from this generalized scheme which have not been explored before and some of them turn out to be more efficient than previously proposed schemes. © 2008 IEEE
Generalized ID-based ElGamal signatures
ID-based cryptography has been a very active area of research in cryptography since bilinear pairings were introduced as a cryptographic tool, and there have been many proposals for ID-based signatures recently. In this paper, we introduce the concept of generalized ID-based ElGamal signatures and show that most of the proposed ID-based signature schemes in the literature are special instances of this generalized scheme. We also obtain numerous new signatures from this generalized scheme which have not been proposed before. ©2007 IEEE
Hayvancılıkla uğraşanlarda ve sığırlarda cryptosporidium spp. yaygınlığının elisa ile araştırılması
4-[3-(1H-Imidazol-1-yl)propyl]-3-methyl-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole monohydrate
In the title compound, C14H17N5S·H2O, the triazole ring makes dihedral angles of 48.15 (8) and 84.92 (8)° with the imidazole and thiophenyl rings, respectively. The water molecule is involved in intermolecular O—H⋯N hydrogen bonding
A comparison of the electrolysis of soil washing wastes with active and non-active electrodes
A comparison between the performance of electrolysis of three different soil-washing wastes with platinum and boron doped diamond (BDD) anodes is carried out in this work. Results demonstrate that the treatment is more efficient with BDD for perchloroethylene and clopyralid but not for the case of lindane, because in this case there is a competitive oxidation between lindane and Sodium Dodecyl Sulfate used to extract this pollutant from soil. First order kinetics are observed in each compound with higher removal at the early stages and generally better results are obtained when using BDD as anode. The evolution of pH and a voltammetry study indicate a higher direct oxidation rate in the case of platinum and more importance of hydroxyl radical mediated processes with diamond anodes. Similar speciation is obtained during the electro-oxidation using BDD and platinum electrodes although the concentration of intermediates vary significantly
Statistical modeling of ground motion relations for seismic hazard analysis
We introduce a new approach for ground motion relations (GMR) in the
probabilistic seismic hazard analysis (PSHA), being influenced by the extreme
value theory of mathematical statistics. Therein, we understand a GMR as a
random function. We derive mathematically the principle of area-equivalence;
wherein two alternative GMRs have an equivalent influence on the hazard if
these GMRs have equivalent area functions. This includes local biases. An
interpretation of the difference between these GMRs (an actual and a modeled
one) as a random component leads to a general overestimation of residual
variance and hazard. Beside this, we discuss important aspects of classical
approaches and discover discrepancies with the state of the art of stochastics
and statistics (model selection and significance, test of distribution
assumptions, extreme value statistics). We criticize especially the assumption
of logarithmic normally distributed residuals of maxima like the peak ground
acceleration (PGA). The natural distribution of its individual random component
(equivalent to exp(epsilon_0) of Joyner and Boore 1993) is the generalized
extreme value. We show by numerical researches that the actual distribution can
be hidden and a wrong distribution assumption can influence the PSHA negatively
as the negligence of area equivalence does. Finally, we suggest an estimation
concept for GMRs of PSHA with a regression-free variance estimation of the
individual random component. We demonstrate the advantages of event-specific
GMRs by analyzing data sets from the PEER strong motion database and estimate
event-specific GMRs. Therein, the majority of the best models base on an
anisotropic point source approach. The residual variance of logarithmized PGA
is significantly smaller than in previous models. We validate the estimations
for the event with the largest sample by empirical area functions. etc
NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment
Transcriptional heterogeneity within embryonic stem cell (ESC) populations has been suggested as a mechanism by which a seemingly homogeneous cell population can initiate differentiation into an array of different cell types. Chromatin remodeling proteins have been shown to control transcriptional variability in yeast and to be important for mammalian ESC lineage commitment. Here we show that the Nucleosome Remodeling and Deacetylation (NuRD) complex, which is required for ESC lineage commitment, modulates both transcriptional heterogeneity and the dynamic range of a set of pluripotency genes in ESCs. In self-renewing conditions, the influence of NuRD at these genes is balanced by the opposing action of self-renewal factors. Upon loss of self-renewal factors, the action of NuRD is sufficient to silence transcription of these pluripotency genes, allowing cells to exit self-renewal. We propose that modulation of transcription levels by NuRD is key to maintaining the differentiation responsiveness of pluripotent cells
Rheumatoid arthritis is still expensive in the new decade: a comparison between two early RA cohorts, diagnosed 1996–98 and 2006–09
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