Is induction of very rapid sustained VT significant in patients with syncope?

Review of: Santos Rego, M. A. (Ed.) (2016). A investigación educativa en Galicia 2002-2014. Vigo: Galaxia. 518 pp. ISBN: 978-84-9865-697-8. Depósito legal: VG 253-2016.This is a work that gathers the main contributions to educational research in Galicia between 2002 and 2014. They listed the main point made research, doctoral theses, books, chapters of books/monographs, articles published in relation to the main areas and core themes related to education as psychology and education, learning disabilities, developmental disorders, educational technology, teacher training, theoretical, philosophical and sociological foundations of education; teaching, school organization and educational innovation... This is a work/book aimed at anyone interested in educational issues in different areas and with the aim of adapting education to social needs Galicia today. Reseña de: Santos Rego, M. A. (Ed.) (2016). A investigación educativa en Galicia 2002-2014. Vigo: Galaxia. 518 pp. ISBN: 978-84-9865-697-8. Depósito legal: VG 253-2016.Se trata de la obra que recoge las principales aportaciones a la investigación educativa en Galicia entre los años 2002 y 2014. Se relacionan las principales investigaciones realizadas, las tesis doctorales leídas,  los libros, capítulos de libros/monografías, artículos publicados en relación con las principales áreas y núcleos temáticos relacionados con la educación como, entre otras, la psicología y la educación, las dificultades de aprendizaje, trastornos del desarrollo, tecnología educativa, formación de profesores, fundamentos teóricos, filosóficos y sociológicos de la educación; didáctica,  organización escolar e innovación educativa… Es una obra dirigida a toda persona interesada por los temas educativos en sus diferentes ámbitos y con el objetivo de adecuar la educación en Galicia  a las necesidades sociales en la actualidad

Becoming an American parent: Overcoming challenges and finding strength in a new immigrant latino community

One in five children living in the United States is an immigrant or a child of an immigrant, and 62% of these children are Latino. Through qualitative methods, this study identifies ways that Latino immigrant parents with adolescent children cope with their new environment and how that environment shapes their parenting practices. Two primary themes emerge: overcoming new challenges and finding new strengths. Immigrant parents discuss the challenges of overcoming fears of the unknown; navigating unfamiliar work, school, and neighborhood environments; encountering and confronting racism; and losing family connections and other forms of social capital. In response to these challenges, immigrant parents discuss developing bicultural coping skills, increasing parent-child communication, empathizing with and respecting their adolescent children, and fostering social supports. The results fit well with a risk and protective factor framework and provide a basis for improving policies and programs to support effective parenting in Latino immigrant families

Multiple time scales and the empirical models for stochastic volatility

The most common stochastic volatility models such as the Ornstein-Uhlenbeck (OU), the Heston, the exponential OU (ExpOU) and Hull-White models define volatility as a Markovian process. In this work we check of the applicability of the Markovian approximation at separate times scales and will try to answer the question which of the stochastic volatility models indicated above is the most realistic. To this end we consider the volatility at both short (a few days) and long (a few months)time scales as a Markovian process and estimate for it the coefficients of the Kramers-Moyal expansion using the data for Dow-Jones Index. It has been found that the empirical data allow to take only the first two coefficients of expansion to be non zero that define form of the volatility stochastic differential equation of Ito. It proved to be that for the long time scale the empirical data support the ExpOU model. At the short time scale the empirical model coincides with ExpOU model for the small volatility quantities only.Comment: 19 pages, 6 figure

Anisotropic Superexchange for nearest and next nearest coppers in chain, ladder and lamellar cuprates

We present a detailed calculation of the magnetic couplings between nearest-neighbor and next-nearest-neighbor coppers in the edge-sharing geometry, ubiquitous in many cuprates. In this geometry, the interaction between nearest neighbor coppers is mediated via two oxygens, and the Cu-O-Cu angle is close to 90 degrees. The derivation is based on a perturbation expansion of a general Hubbard Hamiltonian, and produces numerical estimates for the various magnetic energies. In particular we find the dependence of the anisotropy energies on the angular deviation away from the 90 degrees geometry of the Cu-O-Cu bonds. Our results are required for the correct analysis of the magnetic structure of various chain, ladder and lamellar cuprates.Comment: 13 pages, Latex, 7 figure

Impact of mutant beta-catenin on ABCB1 expression and therapy response in colon cancer cells

Background: Colorectal cancers are often chemoresistant toward antitumour drugs that are substrates for ABCB1-mediated multidrug resistance (MDR). Activation of the Wnt/beta-catenin pathway is frequently observed in colorectal cancers. This study investigates the impact of activated, gain-of-function beta-catenin on the chemoresistant phenotype. Methods: The effect of mutant (mut) beta-catenin on ABCB1 expression and promoter activity was examined using HCT116 human colon cancer cells and isogenic sublines harbouring gain-of-function or wild-type beta-catenin, and patients' tumours. Chemosensitivity towards 24 anticancer drugs was determined by high throughput screening. Results: Cell lines with mut beta-catenin showed high ABCB1 promoter activity and expression. Transfection and siRNA studies demonstrated a dominant role for the mutant allele in activating ABCB1 expression. Patients' primary colon cancer tumours shown to express the same mut beta-catenin allele also expressed high ABCB1 levels. However, cell line chemosensitivities towards 24 MDR-related and non-related antitumour drugs did not differ despite different beta-catenin genotypes. Conclusion: Although ABCB1 is dominantly regulated by mut beta-catenin, this did not lead to drug resistance in the isogenic cell line model studied. In patient samples, the same beta-catenin mutation was detected. The functional significance of the mutation for predicting patients' therapy response or for individualisation of chemotherapy regimens remains to be established

Combining left atrial appendage closure and catheter ablation for atrial fibrillation: 2-year outcomes from a multinational registry

AIMS: Clinical practice guidelines do not recommend discontinuation of long-term oral anticoagulation in patients with a high stroke risk after catheter ablation for atrial fibrillation (AF). Left atrial appendage closure (LAAC) with Watchman has emerged as an alternative to long-term anticoagulation for patients accepting of the procedural risks. We report on the long-term outcomes of combining catheter ablation procedures for AF and LAAC from multicentre registries. METHODS AND RESULTS: Data were pooled from two prospective, real-world

Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine

Patient-derived xenograft (PDX) tumor models represent a valuable platform for identifying new biomarkers and novel targets, to evaluate therapy response and resistance mechanisms. This study aimed at establishment, characterization and therapy testing of colorectal carcinoma-derived PDX. We generated 49 PDX and validated identity between patient tumor and corresponding PDX. Sensitivity of PDX toward conventional and targeted drugs revealed that 92% of PDX responded toward irinotecan, 45% toward 5-FU, 65% toward bevacizumab, and 61% toward cetuximab. Expression of epidermal growth factor receptor (EGFR) ligands correlated to the sensitivity toward cetuximab. Proto-oncogene B-RAF, EGFR, Kirsten rat sarcoma virus oncogene homolog gene copy number correlated positively with cetuximab and erlotinib sensitivity. The mutational analyses revealed an individual mutational profile of PDX and mainly identical profiles of PDX from primary tumor vs corresponding metastasis. Mutation in PIK3CA was a determinant of accelerated tumor doubling time. PDX with wildtype Kirsten rat sarcoma virus oncogene homolog, proto-oncogene B-RAF, and phosphatidylinositol-4,5-bisphosphate 3-kinaseM catalytic subunit alfa showed higher sensitivity toward cetuximab and erlotinib. To study the molecular mechanism of cetuximab resistance, cetuximab resistant PDX models were generated, and changes in HER2, HER3, betacellulin, transforming growth factor alfa were observed. Global proteome and phosphoproteome profiling showed a reduction in canonical EGFR-mediated signaling via PTPN11 (SHP2) and AKT1S1 (PRAS40) and an increase in anti-apoptotic signaling as a consequence of acquired cetuximab resistance. This demonstrates that PDX models provide a multitude of possibilities to identify and validate biomarkers, signaling pathways and resistance mechanisms for clinically relevant improvement in cancer therapy

Desiccation cracks provide evidence of lake drying on Mars, Sutton Island member, Murray formation, Gale Crater

Mars Science Laboratory (MSL) Curiosity rover data are used to describe the morphology of desiccation cracks observed in ancient lacustrine strata at Gale crater, Mars, and to interpret their paleoenvironmental setting. The desiccation cracks indicate subaerial exposure of lacustrine facies in the Sutton Island member of the Murray formation. In association with ripple cross-stratification and possible eolian cross-bedding, these facies indicate a transition from longer-lived perennial lakes recorded by older strata to younger lakes characterized by intermittent exposure. The transition from perennial to episodically exposed lacustrine environments provides evidence for local to regional climate change that can help constrain Mars climate models