358 research outputs found
Recent progress in computing four-loop massive correlators
We report about recent progress in computing four-loop massive correlators.
The expansion of these correlators in the external momentum leads to vacuum
integrals. The calculation of these vacuum integrals can be used to determine
Taylor expansion coefficients of the vacuum polarization function and
decoupling functions in perturbative Quantum chromodynamics. New results at
four-loop order for the lowest Taylor expansion coefficient of the vacuum
polarization function and for the decoupling relation are presented.Comment: 4 pages, talk given at the 12th International Conference on Quantum
Chromodynamics, Montpellier, 4-8th July 200
Scaling algebras and pointlike fields: A nonperturbative approach to renormalization
We present a method of short-distance analysis in quantum field theory that
does not require choosing a renormalization prescription a priori. We set out
from a local net of algebras with associated pointlike quantum fields. The net
has a naturally defined scaling limit in the sense of Buchholz and Verch; we
investigate the effect of this limit on the pointlike fields. Both for the
fields and their operator product expansions, a well-defined limit procedure
can be established. This can always be interpreted in the usual sense of
multiplicative renormalization, where the renormalization factors are
determined by our analysis. We also consider the limits of symmetry actions. In
particular, for suitable limit states, the group of scaling transformations
induces a dilation symmetry in the limit theory.Comment: minor changes and clarifications; as to appear in Commun. Math.
Phys.; 37 page
Radiological prediction of positive circumferential resection margin in oesophageal cancer
Purpose
A positive circumferential resection margin (CRM) is regarded as a poor prognostic indicator in oesophageal cancer (OC) but its prediction can be challenging. MRI is used to predict a threatened CRM in rectal cancer but is not commonly performed in OC unlike PET/CT, which is now routinely used. Therefore, this study assessed the additional predictive value of PET-defined tumour variables compared with EUS and CT T-stage. The prognostic significance of CRM status was also assessed.
Materials and Methods
This retrospective study included 117 consecutive patients [median age 64.0 (range 24–78), 102 males, 110 adenocarcinomas, 6 squamous cell carcinoma (SCC), 1 neuro-endocrine] treated between 1st March 2012 and 31st July 2015. A binary logistic regression model tested 5 staging variables; EUS T-stage (≤T2 vs ≥ T3), CT T-stage (≤T2 vs ≥ T3), PET metabolic tumour length (MTL), PET metabolic tumour width (MTW) and the maximum standardised uptake value (SUVmax).
Results
The CRM was positive in 43.6%. Sixty-seven (57.3%) patients received neo-adjuvant chemotherapy (NACT), 31 patients (26.5%) underwent surgery alone and 19 patients (16.2%) had neo-adjuvant chemo-radiotherapy (NACRT). Median overall survival (OS) was 36.0 months (95% confidence interval (CI) 24.1–47.9) and the 2-year OS was 55.4%. A binary logistic regression model showed EUS ≥ T3 tumours were independently and significantly more likely to have a positive CRM than EUS ≤ T2 tumours (HR 5.188, 95% CI 1.265–21.273, p = 0.022). CT T-stage, PET MTL, PET MTW and SUVmax were not significantly associated with CRM status (p = 0.783, 0.852, 0.605 and 0.413, respectively). There was a significant difference in OS between CRM positive and negative groups (X2 4.920, df 1, p = 0.027).
Conclusion
Advanced EUS T-stage is associated with a positive CRM, but PET-defined tumour variables are unlikely to provide additional predictive information. This study demonstrates the continued benefit of EUS as part of a multi-modality OC staging pathway
QCD Decoupling at Four Loops
We present the matching condition for the strong coupling contant alpha_s at
a heavy quark threshold to four loops in the modified minimal subtraction
scheme. Our results lead to further decrease of the theoretical uncertainty of
the evolution of the strong coupling constant through heavy quark thresholds.
Using a low energy theorem we furthermore derive the effective coupling of the
Higgs boson to gluons (induced by a virtual heavy quark) in four- and
(partially) through five-loop approximation.Comment: 21 pages, 2 figures, the complete paper is also available via the www
at http://www-ttp.physik.uni-karlsruhe.de/Preprints
A pragmatic randomized trial comparing tablet computer informed consent to traditional paper-based methods for an osteoporosis study
AbstractObjectiveMethods to improve informed consent efficiency and effectiveness are needed for pragmatic clinical trials. We compared informed consent using a tablet computer to a paper approach to assess comprehension and satisfaction of patients and clinic staff for a future osteoporosis clinical trial.MethodsNine community-based practices identified and recruited patients to compare the informed consent processes (tablet vs. paper) in a mock osteoporosis clinical trial. The tablet informed consent included an animation summarizing the trial, complete informed consent document, and questions to assess and reinforce comprehension of the study. Participants were women age ≥55 years with ≥1 year of alendronate use. We surveyed participants to assess comprehension and satisfaction and office staff for satisfaction and perceived time demands.ResultsThe nine practices enrolled 33 participants. There was not a significant difference in comprehension between the tablet vs. paper informed consent [mean (SD) tablet: 12.2 (1.0) vs. paper: 11.4 (1.7)]. Office staff preferred the tablet to the paper informed consent for identifying potential study participants (two-sided t-test p = 0.02) despite an increased perceived time spent to complete the tablet process [tablet: 28.3 min (SD 16.3) vs. paper: 19.0 min (SD 6.9); p = 0.08].ConclusionsAlthough, there were no significant differences in participant satisfaction and comprehension with the tablet informed consent compared to a paper informed consent, patients and office staff trended towards greater satisfaction with the tablet informed consent. Larger studies are needed to further evaluate the utility of electronic informed consent in pragmatic clinical trials
ep-Finite Basis of Master Integrals for the Integration-By-Parts Method
It is shown that for every problem within dimensional regularization, using
the Integration-By-Parts method, one is able to construct a set of master
integrals such that each corresponding coefficient function is finite in the
limit of dimension equal to four. We argue that the use of such a basis
simplifies and stabilizes the numerical evaluation of the master integrals. As
an example we explicitly construct the ep-finite basis for the set of all
QED-like four-loop massive tadpoles. Using a semi-numerical approach based on
Pade approximations we evaluate analytically the divergent and numerically the
finite part of this set of master integrals.
The calculations confirm the recent results of Schr\"oder and Vuorinen. All
the contributions found there by fitting the high precision numerical results
have been confirmed by direct analytical calculation without using any
numerical input.Comment: 27 pages, 3 figures, a citation is added, final versio
Nonlinear Realization of Chiral Symmetry on the Lattice
We formulate lattice theories in which chiral symmetry is realized
nonlinearly on the fermion fields. In this framework the fermion mass term does
not break chiral symmetry. This property allows us to use the Wilson term to
remove the doubler fermions while maintaining exact chiral symmetry on the
lattice. Our lattice formulation enables us to address non-perturbative
questions in effective field theories of baryons interacting with pions and in
models involving constituent quarks interacting with pions and gluons. We show
that a system containing a non-zero density of static baryons interacting with
pions can be studied on the lattice without encountering complex action
problems. In our formulation one can also decide non-perturbatively if the
chiral quark model of Georgi and Manohar provides an appropriate low-energy
description of QCD. If so, one could understand why the non-relativistic quark
model works.Comment: 34 pages, 2 figures, revised version to be published in J. High
Energy Phys. (changes in the 1st paragraph, additional descriptions on the
nature of the coordinate singularities in Sec.2, references added
From dynamical scaling to local scale-invariance: a tutorial
Dynamical scaling arises naturally in various many-body systems far from
equilibrium. After a short historical overview, the elements of possible
extensions of dynamical scaling to a local scale-invariance will be introduced.
Schr\"odinger-invariance, the most simple example of local scale-invariance,
will be introduced as a dynamical symmetry in the Edwards-Wilkinson
universality class of interface growth. The Lie algebra construction, its
representations and the Bargman superselection rules will be combined with
non-equilibrium Janssen-de Dominicis field-theory to produce explicit
predictions for responses and correlators, which can be compared to the results
of explicit model studies.
At the next level, the study of non-stationary states requires to go over,
from Schr\"odinger-invariance, to ageing-invariance. The ageing algebra admits
new representations, which acts as dynamical symmetries on more general
equations, and imply that each non-equilibrium scaling operator is
characterised by two distinct, independent scaling dimensions. Tests of
ageing-invariance are described, in the Glauber-Ising and spherical models of a
phase-ordering ferromagnet and the Arcetri model of interface growth.Comment: 1+ 23 pages, 2 figures, final for
HI in the Outskirts of Nearby Galaxies
The HI in disk galaxies frequently extends beyond the optical image, and can
trace the dark matter there. I briefly highlight the history of high spatial
resolution HI imaging, the contribution it made to the dark matter problem, and
the current tension between several dynamical methods to break the disk-halo
degeneracy. I then turn to the flaring problem, which could in principle probe
the shape of the dark halo. Instead, however, a lot of attention is now devoted
to understanding the role of gas accretion via galactic fountains. The current
cold dark matter theory has problems on galactic scales, such as
the core-cusp problem, which can be addressed with HI observations of dwarf
galaxies. For a similar range in rotation velocities, galaxies of type Sd have
thin disks, while those of type Im are much thicker. After a few comments on
modified Newtonian dynamics and on irregular galaxies, I close with statistics
on the HI extent of galaxies.Comment: 38 pages, 17 figures, invited review, book chapter in "Outskirts of
Galaxies", Eds. J. H. Knapen, J. C. Lee and A. Gil de Paz, Astrophysics and
Space Science Library, Springer, in pres
New Results in Four and Five Loop QED calculations
We report on two recent multiloop results in QED: (i) the four-loop
corrections to the conversion relations between the QED charge renormalized in
the on-shell and MS-bar schemes; (ii) analytical evaluation of a class of
asymptotic contributions to the muon anomaly at five-loops.Comment: Talk presented at 9th DESY Workshop on Elementary Particle Theory:
Loops and Legs in Quantum Field Theory, Sondershausen, Germany, 20-25 April
200
- …