63 research outputs found
Superplume mantle tracked isotopically the length of Africa from the Indian Ocean to the Red Sea
Seismological findings show a complex scenario of plume upwellings from a deep thermo-chemical anomaly (superplume) beneath the East African Rift System (EARS). It is unclear if these geophysical observations represent a true picture of the superplume and its influence on magmatism along the EARS. Thus, it is essential to find a geochemical tracer to establish where upwellings are connected to the deep-seated thermo-chemical anomaly. Here we identify a unique non-volatile superplume isotopic signature (βCβ) in the youngest (after 10 Ma) phase of widespread EARS rift-related magmatism where it extends into the Indian Ocean and the Red Sea. This is the first sound evidence that the superplume influences the EARS far from the low seismic velocities in the magma-rich northern half. Our finding shows for the first time that superplume mantle exists beneath the rift the length of Africa from the Red Sea to the Indian Ocean offshore southern Mozambiqu
ΠΠ΅ΡΠΎΠ΄ ΠΈΠ½ΡΠ΅Π³ΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΉ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΌΠ°ΡΠΈΠ½ Ρ Π²ΡΠ°ΡΠ°ΡΡΠΈΠΌΡΡ ΡΠΎΡΠΎΡΠΎΠΌ
ΠΠ»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π² ΡΠ»Π΅ΠΊΡΡΠΎΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΈΡΡΠ΅ΠΌΠ°Ρ
, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠ΅ ΡΡΡΡΠΎΠΉΡΡΠ²Π°, Π²ΠΊΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π² ΡΠ»ΠΎΠΆΠ½ΡΠ΅ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡ
Π΅ΠΌΡ, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΡΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ Colo, ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΡΡΡΠΈΠΉ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠ°Π³Π½ΠΈΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡ
Π΅ΠΌ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π² ΠΌΠ°ΡΡΠΈΡΠ½ΠΎΠΉ ΡΠΎΡΠΌΠ΅. ΠΠ»Π°Π²Π½Π°Ρ ΠΌΠ°ΡΡΠΈΡΠ° ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Colo ΡΠΎΠ΄Π΅ΡΠΆΠΈΡ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΡ ΠΏΡΠΈ ΠΈΡΠΊΠΎΠΌΡΡ
ΡΠΎΠΊΠ°Ρ
ΠΈΠ»ΠΈ ΠΌΠ°Π³Π½ΠΈΡΠ½ΡΡ
ΠΏΠΎΡΠΎΠΊΠ°Ρ
. ΠΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π² ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΈΠ½Π°Ρ
Ρ Π²ΡΠ°ΡΠ°ΡΡΠΈΠΌΡΡ ΡΠΎΡΠΎΡΠΎΠΌ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ ΠΈΠ½ΡΠ΅Π³ΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΉ, Π² ΠΊΠΎΡΠΎΡΡΠ΅ Π²Ρ
ΠΎΠ΄ΡΡ ΠΏΡΠΎΠΈΠ·Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΈΡΠΊΠΎΠΌΡΡ
Π²Π΅Π»ΠΈΡΠΈΠ½, ΠΏΠΎΡΡΠΎΠΌΡ Π½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΠΎ ΡΡΠΈ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Π½Π΅ ΠΌΠΎΠ³ΡΡ ΡΠ΅ΡΠ°ΡΡΡΡ Π² ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΠΎΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ΅ Colo
The Role of Oestrogen Receptor Beta (ERΞ²) in the Aetiology and Treatment of Type 2 Diabetes Mellitus
Introduction: Challenges facing the treatment of type 2 diabetes necessitate the search for agents which act via alternative pathways to provide better therapeutic outcomes. Recently, an increasing body of evidence implicates the activation of oestrogen receptors (ERΞ± and ERΞ²) in the development and treatment of underlying conditions in type 2 diabetes. This article summarizes available evidence for the involvement of oestrogen receptors in insulin secretion, insulin resistance as well as glucose uptake and highlights the potential of ERΞ² as a therapeutic target.
Background: Recent studies indicate an association between the activation of each of the isoforms of ER and recent findings indicate that ERΞ² shows promise as a potential target for antidiabetic drugs. In vitro and in vivo studies in receptor knockout mice indicate beneficial actions of selective agonists of ERΞ² receptor and underscore its therapeutic potential.
Conclusion: Studies are needed to further elucidate the exact mechanism underlying the role of ERΞ² activation as a therapeutic approach in the management of type 2 diabetes
A critical evaluation of the numerical age of the Eocene-Oligocene boundary in βThe Late Eocene Earth - Hothouse, Icehouse, and Impactsβ
- β¦