1,023 research outputs found
Four-Wave mixing in degenerate Fermi gases: Beyond the undepleted pump approximation
We analyze the full nonlinear dynamics of the four-wave mixing between an
incident beam of fermions and a fermionic density grating. We find that when
the number of atoms in the beam is comparable to the number of atoms forming
the grating, the dephasing of that grating, which normally leads to a decay of
its amplitude, is suppressed. Instead, the density grating and the beam density
exhibit large nonlinear coupled amplitude oscillations. In this case four-wave
mixing can persist for much longer times compared to the case of negligible
back-action. We also evaluate the efficiency of the four-wave mixing and show
that it can be enhanced by producing an initial density grating with an
amplitude that is less than the maximum value. These results indicate that
efficient four-wave mixing in fermionic alkali gases should be experimentally
observable.Comment: 9 pages, 8 figure
Controlling collapse in Bose-Einstein condensates by temporal modulation of the scattering length
We consider, by means of the variational approximation (VA) and direct
numerical simulations of the Gross-Pitaevskii (GP) equation, the dynamics of 2D
and 3D condensates with a scattering length containing constant and
harmonically varying parts, which can be achieved with an ac magnetic field
tuned to the Feshbach resonance. For a rapid time modulation, we develop an
approach based on the direct averaging of the GP equation,without using the VA.
In the 2D case, both VA and direct simulations, as well as the averaging
method, reveal the existence of stable self-confined condensates without an
external trap, in agreement with qualitatively similar results recently
reported for spatial solitons in nonlinear optics. In the 3D case, the VA again
predicts the existence of a stable self-confined condensate without a trap. In
this case, direct simulations demonstrate that the stability is limited in
time, eventually switching into collapse, even though the constant part of the
scattering length is positive (but not too large). Thus a spatially uniform ac
magnetic field, resonantly tuned to control the scattering length, may play the
role of an effective trap confining the condensate, and sometimes causing its
collapse.Comment: 7 figure
Dynamics of Fermionic Four-Wave Mixing
We study the dynamics of a beam of fermions diffracted off a density grating
formed by fermionic atoms in the limit of a large grating. An exact description
of the system in terms of particle-hole operators is developed. We use a
combination of analytical and numerical methods to quantitatively explore the
Raman-Nath and the Bragg regimes of diffraction. We discuss the limits in
diffraction efficiency resulting from the dephasing of the grating due the
distribution of energy states occupied by the fermions. We propose several
methods to overcome these limits, including the novel technique of ``atom
echoes''.Comment: 8 pages, 7 figure
From “Homegrown” to Research-Ready: Converting an Existing Practitioner-Developed Violence Prevention Intervention Into an Evaluable Intervention
There is an increased call for research on promising prevention programs already embedded in communities (“homegrown interventions”). Unfortunately, there is limited guidance to help researchers prepare these types of interventions for rigorous evaluation. To address this need, this article presents our team’s process for revising a promising community-based sexual violence prevention intervention for rigorous research. Our extensive and iterative process of reviewing and revising the intervention was guided by evaluability assessment (EA) approaches, implementation science, and a close collaboration with our community partners. Our EA process allowed us to specify the intervention’s core components and develop a “research ready” standardized curriculum with implementation fidelity assessments. We offer four lessons learned from our process: (1) even with existing materials and an extensive history of community-based delivery, community-developed programs are not necessarily research-ready; (2) close collaboration and a trusting relationship between researchers and community partners throughout the revision process ensures the integrity of core program components are maintained and implementation in diverse community settings is feasible; (3) observations of program implementation are a crucial part of the revision process; and (4) it is important to budget adequate time and resources for such revisions
String Theoretic Bounds on Lorentz-Violating Warped Compactification
We consider warped compactifications that solve the 10 dimensional
supergravity equations of motion at a point, stabilize the position of a
D3-brane world, and admit a warp factor that violates Lorentz invariance along
the brane. This gives a string embedding of ``asymmetrically warped'' models
which we use to calculate stringy (\alpha') corrections to standard model
dispersion relations, paying attention to the maximum speeds for different
particles. We find, from the dispersion relations, limits on gravitational
Lorentz violation in these models, improving on current limits on the speed of
graviton propagation, including those derived from field theoretic loops. We
comment on the viability of models that use asymmetric warping for self-tuning
of the brane cosmological constant.Comment: 20pg, JHEP3; v2 additional references, slight change to intro; v3.
added referenc
Ramond-Ramond Fields, Fractional Branes and Orbifold Differential K-Theory
We study D-branes and Ramond-Ramond fields on global orbifolds of Type II
string theory with vanishing H-flux using methods of equivariant K-theory and
K-homology. We illustrate how Bredon equivariant cohomology naturally realizes
stringy orbifold cohomology. We emphasize its role as the correct cohomological
tool which captures known features of the low-energy effective field theory,
and which provides new consistency conditions for fractional D-branes and
Ramond-Ramond fields on orbifolds. We use an equivariant Chern character from
equivariant K-theory to Bredon cohomology to define new Ramond-Ramond couplings
of D-branes which generalize previous examples. We propose a definition for
groups of differential characters associated to equivariant K-theory. We derive
a Dirac quantization rule for Ramond-Ramond fluxes, and study flat
Ramond-Ramond potentials on orbifolds.Comment: 46 pages; v2: typos correcte
Advantages of a Modular Mars Surface Habitat Approach
Early crewed Mars mission concepts developed by the National Aeronautics and Space Administration (NASA) assumed a single, large habitat would house six crew members for a 500-day Mars surface stay. At the end of the first mission, all surface equipment, including the habitat, -would be abandoned and the process would be repeated at a different Martian landing site. This work was documented in a series of NASA publications culminating with the Mars Design Reference Mission 5.0 (NASA-SP-2009-566). The Evolvable Mars Campaign (EMC) explored whether re-using surface equipment at a single landing site could be more affordable than the Apollo-style explore-abandon-repeat mission cadence. Initial EMC assumptions preserved the single, monolithic habitat, the only difference being a new requirement to reuse the surface habitat for multiple expedition crews. A trade study comparing a single large habitat versus smaller, modular habitats leaned towards the monolithic approach as more mass-efficient. More recent work has focused on the operational aspects of building up Mars surface infrastructure over multiple missions, and has identified compelling advantages of the modular approach that should be considered before making a final decision. This paper explores Mars surface mission operational concepts and integrated system analysis, and presents an argument for the modular habitat approach
Is It Rational to Assume that Infants Imitate Rationally? A Theoretical Analysis and Critique
It has been suggested that preverbal infants evaluate the efficiency of others' actions (by applying a principle of rational action) and that they imitate others' actions rationally. The present contribution presents a conceptual analysis of the claim that preverbal infants imitate rationally. It shows that this ability rests on at least three assumptions: that infants are able to perceive others' action capabilities, that infants reason about and conceptually represent their own bodies, and that infants are able to think counterfactually. It is argued that none of these three abilities is in place during infancy. Furthermore, it is shown that the idea of a principle of rational action suffers from two fallacies. As a consequence, is it suggested that it is not rational to assume that infants imitate rationally. Copyright (C) 2012 S. Karger AG, Base
Neoadjuvant pazopanib and molecular analysis of tissue response in renal cell carcinoma
BACKGROUND. Surgery remains the frontline therapy for patients with localized clear cell renal cell carcinoma (ccRCC); however, 20%–40% recur. Angiogenesis inhibitors have improved survival in metastatic patients and may result in responses in the neoadjuvant setting. The impact of these agents on the tumor genetic heterogeneity or the immune milieu is largely unknown. This phase II study was designed to evaluate safety, response, and effect on tumor tissue of neoadjuvant pazopanib. METHODS. ccRCC patients with localized disease received pazopanib (800 mg daily; median 8 weeks), followed by nephrectomy. Five tumors were examined for mutations by whole exome sequencing from samples collected before therapy and at nephrectomy. These samples underwent RNA sequencing; 17 samples were available for posttreatment assessment. RESULTS. Twenty-one patients were enrolled. The overall response rate was 8 of 21 (38%). No patients with progressive disease. At 1-year, response-free survival and overall survival was 83% and 89%, respectively. The most frequent grade 3 toxicity was hypertension (33%, 7 of 21). Sequencing revealed strong concordance between pre- and posttreatment samples within individual tumors, suggesting tumors harbor stable core profiles. However, a reduction in private mutations followed treatment, suggesting a selective process favoring enrichment of driver mutations. CONCLUSION. Neoadjuvant pazopanib is safe and active in ccRCC. Future genomic analyses may enable the segregation of driver and passenger mutations. Furthermore, tumor infiltrating immune cells persist during therapy, suggesting that pazopanib can be combined with immune checkpoint inhibitors without dampening the immune response. FUNDING. Support was provided by Novartis and GlaxoSmithKline as part of an investigator-initiated study
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