FIRST CRYOMODULE TEST AT AMTF HALL FOR THE EUROPEAN X-RAY FREE ELECTRON LASER (XFEL)

Abstract The Accelerator Module Test Facility (AMTF) at DESY in Hamburg is dedicated to the tests of RF cavities and accelerating cryomodules for the European X-ray Free Electron Laser (XFEL). The AMTF hall is equipped with two vertical cryostats, which are used for RF cavities testing and three test benches that will be used for tests of the accelerating cryomodules. Recently, the first cryomodule teststand (XATB3) was commissioned and the first XFEL cryomodule (XM-2) was tested by team of physicists, engineers and technicians from The Henry

Outcomes of truncal vascular injuries in children.

BACKGROUND: Pediatric truncal vascular injuries occur infrequently and have a reported mortality rate of 30% to 50%. This report examines the demographics, mechanisms of injury, associated trauma, and outcome of patients presenting for the past 10 years at a single institution with truncal vascular injuries. METHODS: A retrospective review (1997-2006) of a pediatric trauma registry at a single institution was undertaken. RESULTS: Seventy-five truncal vascular injuries occurred in 57 patients (age, 12 +/- 3 years); the injury mechanisms were penetrating in 37%. Concomitant injuries occurred with 76%, 62%, and 43% of abdominal, thoracic, and neck vascular injuries, respectively. Nonvascular complications occurred more frequently in patients with abdominal vascular injuries who were hemodynamically unstable on presentation. All patients with thoracic vascular injuries presenting with hemodynamic instability died. In patients with neck vascular injuries, 1 of 2 patients who were hemodynamically unstable died, compared to 1 of 12 patients who died in those who presented hemodynamically stable. Overall survival was 75%. CONCLUSIONS: Survival and complications of pediatric truncal vascular injury are related to hemodynamic status at the time of presentation. Associated injuries are higher with trauma involving the abdomen

Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish

Aminoacyl tRNA synthetases (ARSs) link specific amino acids with their cognate transfer RNAs in a critical early step of protein translation. Mutations in ARSs have emerged as a cause of recessive, often complex neurological disease traits. Here we report an allelic series consisting of seven novel and two previously reported biallelic variants in valyl-tRNA synthetase (VARS) in ten patients with a developmental encephalopathy with microcephaly, often associated with early-onset epilepsy. In silico, in vitro, and yeast complementation assays demonstrate that the underlying pathomechanism of these mutations is most likely a loss of protein function. Zebrafish modeling accurately recapitulated some of the key neurological disease traits. These results provide both genetic and biological insights into neurodevelopmental disease and pave the way for further in-depth research on ARS related recessive disorders and precision therapies

History, Commemoration, and Belief: Abraham Lincoln in American Memory, 1945-2001

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91765/1/Schuman-History_Commemoration_Belief.pd

Changes of the human gut microbiome induced by a fermented milk product

The gut microbiota (GM) consists of resident commensals and transient microbes conveyed by the diet but little is known about the role of the latter on GM homeostasis. Here we show, by a conjunction of quantitative metagenomics, in silico genome reconstruction and metabolic modeling, that consumption of a fermented milk product containing dairy starters and Bifidobacterium animalis potentiates colonic short chain fatty acids production and decreases abundance of a pathobiont Bilophila wadsworthia compared to a milk product in subjects with irritable bowel syndrome (IBS, n = 28). The GM changes parallel improvement of IBS state, suggesting a role of the fermented milk bacteria in gut homeostasis. Our data challenge the view that microbes ingested with food have little impact on the human GM functioning and rather provide support for beneficial health effects

Austenite Grain Size Estimtion from Chord Lengths of Logarithmic-Normal Distribution

Linear section of grains in polyhedral material microstructure is a system of chords. The mean length of chords is the linear grain size of the microstructure. For the prior austenite grains of low alloy structural steels, the chord length is a random variable of gamma- or logarithmic-normal distribution. The statistical grain size estimation belongs to the quantitative metallographic problems. The so-called point estimation is a well known procedure. The interval estimation (grain size confidence interval) for the gamma distribution was given elsewhere, but for the logarithmic-normal distribution is the subject of the present contribution. The statistical analysis is analogous to the one for the gamma distribution

Austenite Grain Size Estimation in Structural Steels by Linear Section Method / Ocena Wielkości Ziarna Austenitu Metodą Przekrojów Liniowych

Linear section of grains in polyhedral material microstructure is a system of chords on a test line. The mean chord length is the linear grain size of the material. In the prior austenite microstructure of low alloy structural steels, the chord length is a random variable which has the gamma distribution. The distribution parameters are closely related to the austenite linear grain size. Because the sequent chord lengths are statistically independent, the grain size interval estimation (confidence interval) may be performed by the chi-square distribution