Bounds on New Physics from B -> V1 V2 Decays

We consider the possibility that physics beyond the standard model contributes to the decays B -> V1 V2, where V1 and V2 are vector mesons. We show that a time-dependent angular analysis of B -> V1 V2 decays provides many tests for this new physics (NP). Furthermore, although one cannot solve for the NP parameters, we show that this angular analysis allows one to put bounds on these parameters. This can be useful in estimating the scale of NP, and can tell us whether any NP found directly at future high-energy colliders can be responsible for effects seen in B -> V1 V2 decays.Comment: 23 pages, plain LaTeX, 5 figures (included

New Physics Effects From B Meson Decays

In this talk, we point out some of the present and future possible signatures of physics beyond the Standard Model from B-meson decays, taking R-parity conserving and violating supersymmetry as illustrative examples.Comment: Talk given at the Sixth Workshop on High Energy Particle Phenomenology (WHEPP-6), Chennai (Madras), India. Includes 2 epsf figure

Magnetism, superconductivity and coupling in cuprate heterostructures probed by low-energy muon-spin rotation

We present a low-energy muon-spin-rotation study of the magnetic and superconducting properties of YBa2Cu3O7/PrBa2Cu3O7 trilayer and bilayer heterostructures. By determining the magnetic-field profiles throughout these structures we show that a finite superfluid density can be induced in otherwise semiconducting PrBa2Cu3O7 layers when juxtaposed to YBa2Cu3O7 "electrodes" while the intrinsic antiferromagnetic order is unaffected.Comment: 10 pages, 9 figures; figure 9 corrected in version

Retardation turns the van der Waals attraction into Casimir repulsion already at 3 nm

Casimir forces between surfaces immersed in bromobenzene have recently been measured by Munday et al. Attractive Casimir forces were found between gold surfaces. The forces were repulsive between gold and silica surfaces. We show the repulsion is due to retardation effects. The van der Waals interaction is attractive at all separations. The retardation driven repulsion sets in already at around 3 nm. To our knowledge retardation effects have never been found at such a small distance before. Retardation effects are usually associated with large distances

Local overexpression of the myostatin propeptide increases glucose transporter expression and enhances skeletal muscle glucose disposal

Insulin resistance (IR) in skeletal muscle is a prerequisite for type 2 diabetes and is often associated with obesity. IR also develops alongside muscle atrophy in older individuals in sarcopenic obesity. The molecular defects that underpin this syndrome are not well characterized, and there is no licensed treatment. Deletion of the transforming growth factor-β family member myostatin, or sequestration of the active peptide by overexpression of the myostatin propeptide/latency-associated peptide (ProMyo) results in both muscle hypertrophy and reduced obesity and IR. We aimed to establish whether local myostatin inhibition would have a paracrine/autocrine effect to enhance glucose disposal beyond that simply generated by increased muscle mass, and the mechanisms involved. We directly injected adeno-associated virus expressing ProMyo in right tibialis cranialis/extensor digitorum longus muscles of rats and saline in left muscles and compared the effects after 17 days. Both test muscles were increased in size (by 7 and 11%) and showed increased radiolabeled 2-deoxyglucose uptake (26 and 47%) and glycogen storage (28 and 41%) per unit mass during an intraperitoneal glucose tolerance test. This was likely mediated through increased membrane protein levels of GLUT1 (19% higher) and GLUT4 (63% higher). Interestingly, phosphorylation of phosphoinositol 3-kinase signaling intermediates and AMP-activated kinase was slightly decreased, possibly because of reduced expression of insulin-like growth factor-I in these muscles. Thus, myostatin inhibition has direct effects to enhance glucose disposal in muscle beyond that expected of hypertrophy alone, and this approach may offer potential for the therapy of IR syndrome

Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival

MiRNAs regulate gene expression at a post-transcriptional level and their dysregulation can play major roles in the pathogenesis of many different forms of cancer, including neuroblastoma, an often fatal paediatric cancer originating from precursor cells of the sympathetic nervous system. We have analyzed a set of neuroblastoma (n = 145) that is broadly representative of the genetic subtypes of this disease for miRNA expression (430 loci by stem-loop RT qPCR) and for DNA copy number alterations (array CGH) to assess miRNA involvement in disease pathogenesis. The tumors were stratified and then randomly split into a training set (n = 96) and a validation set (n = 49) for data analysis. Thirty-seven miRNAs were significantly over-or under-expressed in MYCN amplified tumors relative to MYCN single copy tumors, indicating a potential role for the MYCN transcription factor in either the direct or indirect dysregulation of these loci. In addition, we also determined that there was a highly significant correlation between miRNA expression levels and DNA copy number, indicating a role for large-scale genomic imbalances in the dysregulation of miRNA expression. In order to directly assess whether miRNA expression was predictive of clinical outcome, we used the Random Forest classifier to identify miRNAs that were most significantly associated with poor overall patient survival and developed a 15 miRNA signature that was predictive of overall survival with 72.7% sensitivity and 86.5% specificity in the validation set of tumors. We conclude that there is widespread dysregulation of miRNA expression in neuroblastoma tumors caused by both over-expression of the MYCN transcription factor and by large-scale chromosomal imbalances. MiRNA expression patterns are also predicative of clinical outcome, highlighting the potential for miRNA mediated diagnostics and therapeutics

R-parity-violating SUSY and CP violation in B --> phi K_s

Recent measurements of CP asymmetry in B --> phi K_S appear to be inconsistent with Standard Model expectations. We explore the effect of R-parity-violating SUSY to understand the data.Comment: Equations corrected. Conclusions unchanged. Latex, 6 pages, one fi

New-Physics Effects on Triple-Product Correlations in Lambda_b Decays

We adopt an effective-lagrangian approach to compute the new-physics contributions to T-violating triple-product correlations in charmless Lambda_b decays. We use factorization and work to leading order in the heavy-quark expansion. We find that the standard-model (SM) predictions for such correlations can be significantly modified. For example, triple products which are expected to vanish in the SM can be enormous (~50%) in the presence of new physics. By measuring triple products in a variety of Lambda_b decays, one can diagnose which new-physics operators are or are not present. Our general results can be applied to any specific model of new physics by simply calculating which operators appear in that model.Comment: 20 pages, LaTeX, no figures. Added a paragraph (+ references) discussing nonfactorizable effects. Conclusions unchange

Magnetic Field-Induced Condensation of Triplons in Han Purple Pigment BaCuSi2_2O6_6

Besides being an ancient pigment, BaCuSi$_2$O$_6$ is a quasi-2D magnetic insulator with a gapped spin dimer ground state. The application of strong magnetic fields closes this gap creating a gas of bosonic spin triplet excitations called triplons. The topology of the spin lattice makes BaCuSi$_2$O$_6$ an ideal candidate for studying the Bose-Einstein condensation of triplons as a function of the external magnetic field, which acts as a chemical potential. In agreement with quantum Monte Carlo numerical simulations, we observe a distinct lambda-anomaly in the specific heat together with a maximum in the magnetic susceptibility upon cooling down to liquid Helium temperatures.Comment: published on August 20, 200

Metallic Xenon, Molecular Condensates, and Superconductivity

A possibility of explaining the light absorption observed to occur under pressure-induced xenon metallization as due to the transition to the superconducting state is analyzed. The mechanism of the van der Waals bonding is discussed.Comment: LaTeX 2.09 (RevTeX), 4 pages, 4 PostScript figures included in tex