414 research outputs found
Can one hear the shape of the Universe?
It is shown that the recent observations of NASA's explorer mission
"Wilkinson Microwave Anisotropy Probe" (WMAP) hint that our Universe may
possess a non-trivial topology. As an example we discuss the Picard space which
is stretched out into an infinitely long horn but with finite volume.Comment: 4 page
Do pathogens from corneal scraping show their true colours better in bactec bottles?
Identification of causative organisms of clinically suspected microbial keratitis is very important so that appropriate targeted antimicrobial treatment can be offered to patients. The current routine method of corneal scraping specimens on to multiple agar culture plates for microbiological study is not really providing encouraging result. Our trial of modified technique of using BACTEC broth for three clinically suspected microbial keratitis cases worked 100% to identify the causative organisms in cases of microbial keratitis
The Histone Deacetylase Inhibitor Romidepsin Spares Normal Tissues While Acting as an Effective Radiosensitizer in Bladder Tumors in Vivo
Funding Information: This work was funded by Cancer Research UK (CRUK; C5255/A23755). J.L.R. was funded by CRUK (project grant C15140/A19817). C.K.T. was funded by a CRUK DPhil Research Training and Support Grant, the Balliol College Alfred Douglas Stone Scholarship, and the University of Oxford Clarendon Fund. S.K. was funded by a CRUK/MRC Oxford Institute of Radiation Oncology CRUK studentship.Peer reviewedPublisher PD
Utilization of photon orbital angular momentum in the low-frequency radio domain
We show numerically that vector antenna arrays can generate radio beams which
exhibit spin and orbital angular momentum characteristics similar to those of
helical Laguerre-Gauss laser beams in paraxial optics. For low frequencies (< 1
GHz), digital techniques can be used to coherently measure the instantaneous,
local field vectors and to manipulate them in software. This opens up for new
types of experiments that go beyond those currently possible to perform in
optics, for information-rich radio physics applications such as radio
astronomy, and for novel wireless communication concepts.Comment: 4 pages, 5 figures. Changed title, identical to the paper published
in PR
Occurrence of periodic Lam\'e functions at bifurcations in chaotic Hamiltonian systems
We investigate cascades of isochronous pitchfork bifurcations of
straight-line librating orbits in some two-dimensional Hamiltonian systems with
mixed phase space. We show that the new bifurcated orbits, which are
responsible for the onset of chaos, are given analytically by the periodic
solutions of the Lam\'e equation as classified in 1940 by Ince. In Hamiltonians
with C_ symmetry, they occur alternatingly as Lam\'e functions of period
2K and 4K, respectively, where 4K is the period of the Jacobi elliptic function
appearing in the Lam\'e equation. We also show that the two pairs of orbits
created at period-doubling bifurcations of touch-and-go type are given by two
different linear combinations of algebraic Lam\'e functions with period 8K.Comment: LaTeX2e, 22 pages, 14 figures. Version 3: final form of paper,
accepted by J. Phys. A. Changes in Table 2; new reference [25]; name of
bifurcations "touch-and-go" replaced by "island-chain
Hypertonic Stress Promotes the Upregulation and Phosphorylation of Zonula Occludens 1
Tight junction molecules form a barrier between adjacent cells and mediate the cells’ ability to develop membranes that constitute boundaries of different compartments within the body. Membranes with selective ion and water passage are important for the electrolyte and water homeostasis in the kidney. Due to their role in the urinary concentration process, renal medullary cells are exposed to hyperosmotic stress. Therefore, we were interested in the question of how mouse inner medullary collecting duct cells (mIMCD3) manage to maintain their cell-cell contacts, despite hypertonicity-induced cell shrinkage. Employing mRNA expression analysis, we found that the zonula occludens type 1 (Zo-1), multi-PDZ domain protein 1 (MUPP1) and cortactin mRNA levels were upregulated in a tonicity-dependent manner. Using Western blot analysis, immunoprecipitation and immunofluorescence, we show that the Zo-1 protein is upregulated, phosphorylated and linked to the actin cytoskeleton in response to hypertonic stress. After cell exposure to hypertonicity, rearrangement of the actin cytoskeleton resulted in a stronger colocalization of actin fibres with Zo-1. Urea, which generates hyperosmolality, but no transcellular gradient, did not induce changes in Zo-1 protein expression or actin rearrangement. This data indicates that Zo-1 is a response protein to inner medullary tonicity and that extracellular stressors can promote Zo-1 protein expression, tyrosine phosphorylation and cytoskeleton association
Enhanced five-port ring circuit reflectometer for synthetic breast tissue dielectric determination
In this study,a Six-port Reflectometer (SPR) with dielectric probe sensor is used to predict relative dielectric,εr of normal and tumorous breast tissue in frequency range from 2.34GHz to 3.0GHz. Other than that,a superstrate with an exterior copper layer is overlaid on the surface of a primitive Five-port Ring Circuit (FPRC),which is also a denominated,enhanced superstrate FPRC. It is the main component of the SPR and is presented in this paper as well. The enhanced superstrate FPRC is capable of improving its operating bandwidth by 26% and shifting the operating centre frequency to a lower value without increasing circuit physical size. The detailed design and characteristics of the FPRC are described here. In addition,the enhanced superstrate FPRC is integrated into the SPR for one-port reflection coefficient measurement. The measurement using the SPR is benchmarked with Agilent’s E5071C Vector Network Analyzer (VNA) for one-port reflection coefficient. Maximum absolute mean error of the linear magnitude and phase measurements are recorded to be 0.03 and 5.50°,respectively. In addition,maximum absolute error of the predicted dielectric and loss factor are 1.77 and 0.61,respectively
Glatiramer Acetate Treatment in Multiple Sclerosis-Associated Fatigue—Beneficial Effects on Self-Assessment Scales But Not on Molecular Markers
Although fatigue is a common symptom in multiple sclerosis (MS), its pathomechanisms are incompletely understood. Glatiramer acetate (GA), an immunomodulatory agent approved for treatment of relapsing-remitting MS (RRMS), possesses unique mechanisms of action and has been shown to exhibit beneficial effects on MS fatigue. The objective of this study was to correlate clinical, neuropsychological, and immunological parameters in RRMS patients with fatigue before and during treatment with GA. In a prospective, open-label, multicenter trial, 30 patients with RRMS and fatigue were treated with GA for 12 months. Inclusion criterion was the presence of fatigue as one of the most frequent and disabling symptoms. Before and during treatment, fatigue was assessed using the Fatigue Severity Scale (FSS), the MS-FSS, and the Modified Fatigue Impact Scale (MFIS). In addition, fatigue and quality of life were assessed using the Visual Analog Scales (VAS). Laboratory assessments included screening of 188 parameters using real-time PCR microarrays followed by further analysis of several cytokines, chemokines, and neurotrophic factors. Fatigue self-assessments were completed in 25 patients. After 12 months of treatment with GA, 13 of these patients improved in all three scales (with the most prominent effects on the MFIS), whereas 5 patients had deteriorated. The remaining 7 patients exhibited inconsistent effects within the three scales. Fatigue and overall quality of life had improved, as assessed via VAS. Laboratory assessments revealed heterogeneous mRNA levels of cytokines, chemokines, and neurotrophic factors. In conclusion, we were not able to correlate clinical and molecular effects of GA in patients with RRMS and fatigue
Three closely related (2E,200E)-3,300-(1,4-phenylene)- bis[1-(methoxyphenyl)prop-2-en-1-ones]: supramolecular assemblies in one dimension mediated by hydrogen bonding and C—Hp interactions
In the title compounds, (2E,20E)-3,30-(1,4-phenylene)bis[1-(2-methoxyphenyl)-
prop-2-en-1-one], C26H22O4 (I), (2E,20E)-3,30-(1,4-phenylene)bis[1-(3-methoxyphenyl)
prop-2-en-1-one], C26H22O4 (II) and (2E,20E)-3,30-(1,4-phenylene)bis[1-
(3,4-dimethoxyphenyl)prop-2-en-1-one], C28H26O6 (III), the asymmetric unit
consists of a half-molecule, completed by crystallographic inversion symmetry.
The dihedral angles between the central and terminal benzene rings are
56.98 (8), 7.74 (7) and 7.73 (7) for (I), (II) and (III), respectively. In the crystal
of (I), molecules are linked by pairs of C—H interactions into chains
running parallel to [101]. The packing for (II) and (III), features inversion
dimers linked by pairs of C—HO hydrogen bonds, forming R2
2(16) and R2
2(14)
ring motifs, respectively, as parts of [201] and [101] chains, respectively
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