Giant Colloidal Diffusivity on Corrugated Optical Vortices

A single colloidal sphere circulating around a periodically modulated optical vortex trap can enter a dynamical state in which it intermittently alternates between freely running around the ring-like optical vortex and becoming trapped in local potential energy minima. Velocity fluctuations in this randomly switching state still are characterized by a linear Einstein-like diffusion law, but with an effective diffusion coefficient that is enhanced by more than two orders of magnitude.Comment: 4 pages, 4 figure

Colloidal hydrodynamic coupling in concentric optical vortices

Optical vortex traps created from helical modes of light can drive fluid-borne colloidal particles in circular trajectories. Concentric circulating rings of particles formed by coaxial optical vortices form a microscopic Couette cell, in which the amount of hydrodynamic drag experienced by the spheres depends on the relative sense of the rings' circulation. Tracking the particles' motions makes possible measurements of the hydrodynamic coupling between the circular particle trains and addresses recently proposed hydrodynamic instabilities for collective colloidal motions on optical vortices.Comment: 7 pages, 2 figures, submitted to Europhysics Letter

The cancer's Margins project: access to knowledge and Its mobilization by LGBQ/T cancer patients

Sexual and/or gender minority populations (LGBQ/T) have particular cancer risks, lower involvement in cancer screening, and experience barriers in communication with healthcare providers. All of these factors increase the probability of health decisions linked with poor outcomes that include higher levels of cancer mortality. Persistent discrimination against, and stigmatization of, LGBQ/T people is reflected in sparse medical curriculum addressing LGBQ/T communities. Marginalization makes LGBQ/T persons particularly reliant on knowledge derived from online networks and mainstream media sources. In what is likely the first nationally-funded and nation-wide study of LGBQ/T experiences of cancer, the Cancer's Margins project (www.lgbtcancer.ca) conducted face-to-face interviews with 81 sexual and/or gender minority patients diagnosed and treated for breast and/or gynecological cancer in five Canadian provinces and the San Francisco Bay area (US). With specific attention to knowledge access, sharing, and mobilization, our objective was to document and analyze complex intersectional relationships between marginalization, gender and sexuality, and cancer health decision-making and care experiences. Findings indicate that cancer care knowledge in online environments is shaped by cisnormative and heteronormative narratives. Cancer knowledge and support environments need, by contrast, to be designed by taking into account intersectionally diverse models of minority identities and communities

Entanglement by linear SU(2) transformations: generation and evolution of quantum vortex states

We consider the evolution of a two-mode system of bosons under the action of a Hamiltonian that generates linear SU(2) transformations. The Hamiltonian is generic in that it represents a host of entanglement mechanisms, which can thus be treated in a unified way. We start by solving the quantum dynamics analytically when the system is initially in a Fock state. We show how the two modes get entangled by evolution to produce a coherent superposition of vortex states in general, and a single vortex state under certain conditions. The degree of entanglement between the modes is measured by finding the explicit analytical dependence of the Von Neumann entropy on the system parameters. The reduced state of each mode is analyzed by means of its correlation function and spatial coherence function. Remarkably, our analysis is shown to be equally as valid for a variety of initial states that can be prepared from a two-mode Fock state via a unitary transformation and for which the results can be obtained by mere inspection of the corresponding results for an initial Fock state. As an example, we consider a quantum vortex as the initial state and also find conditions for its revival and charge conjugation. While studying the evolution of the initial vortex state, we have encountered and explained an interesting situation in which the entropy of the system does not evolve whereas its wave function does. Although the modal concept has been used throughout the paper, it is important to note that the theory is equally applicable for a two-particle system in which each particle is represented by its bosonic creation and annihilation operators.Comment: 6 figure

Polarisation Patterns and Vectorial Defects in Type II Optical Parametric Oscillators

Previous studies of lasers and nonlinear resonators have revealed that the polarisation degree of freedom allows for the formation of polarisation patterns and novel localized structures, such as vectorial defects. Type II optical parametric oscillators are characterised by the fact that the down-converted beams are emitted in orthogonal polarisations. In this paper we show the results of the study of pattern and defect formation and dynamics in a Type II degenerate optical parametric oscillator for which the pump field is not resonated in the cavity. We find that traveling waves are the predominant solutions and that the defects are vectorial dislocations which appear at the boundaries of the regions where traveling waves of different phase or wave-vector orientation are formed. A dislocation is defined by two topological charges, one associated with the phase and another with the wave-vector orientation. We also show how to stabilize a single defect in a realistic experimental situation. The effects of phase mismatch of nonlinear interaction are finally considered.Comment: 38 pages, including 15 figures, LATeX. Related material, including movies, can be obtained from http://www.imedea.uib.es/Nonlinear/research_topics/OPO

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits — The Hispanic/Latino Anthropometry Consortium

Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and overweight/obesity. To address this knowledge gap, we analyzed densely imputed genetic data in a sample of Hispanic/Latino adults to identify and fine-map genetic variants associated with body mass index (BMI), height, and BMI-adjusted waist-to-hip ratio (WHRadjBMI). We conducted a GWAS of 18 studies/consortia as part of the Hispanic/Latino Anthropometry (HISLA) Consortium (stage 1, n = 59,771) and generalized our findings in 9 additional studies (stage 2, n = 10,538). We conducted a trans-ancestral GWAS with summary statistics from HISLA stage 1 and existing consortia of European and African ancestries. In our HISLA stage 1 + 2 analyses, we discovered one BMI locus, as well as two BMI signals and another height signal each within established anthropometric loci. In our trans-ancestral meta-analysis, we discovered three BMI loci, one height locus, and one WHRadjBMI locus. We also identified 3 secondary signals for BMI, 28 for height, and 2 for WHRadjBMI in established loci. We show that 336 known BMI, 1,177 known height, and 143 known WHRadjBMI (combined) SNPs demonstrated suggestive transferability (nominal significance and effect estimate directional consistency) in Hispanic/Latino adults. Of these, 36 BMI, 124 height, and 11 WHRadjBMI SNPs were significant after trait-specific Bonferroni correction. Trans-ancestral meta-analysis of the three ancestries showed a small-to-moderate impact of uncorrected population stratification on the resulting effect size estimates. Our findings demonstrate that future studies may also benefit from leveraging diverse ancestries and differences in linkage disequilibrium patterns to discover novel loci and additional signals with less residual population stratification

A trans-ancestral meta-analysis of Genome-wide Association Studies reveals loci associated with childhood obesity

Although hundreds of GWAS-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity, and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated with childhood obesity, we performed a trans-ancestral meta-analysis of thirty studies consisting of up to 13,005 cases (≥95th percentile of BMI achieved 2-18 years old) and 15,599 controls (consistently <50th percentile of BMI) of European, African, North/South American and East Asian ancestry. Suggestive loci were taken forward for replication in a sample of 1,888 cases and 4,689 controls from seven cohorts of European and North/South American ancestry. In addition to observing eighteen previously implicated BMI or obesity loci, for both early and late onset, we uncovered one completely novel locus in this trans-ancestral analysis (nearest gene: METTL15). The variant was nominally associated in only the European subgroup analysis but had a consistent direction of effect in other ethnicities. We then utilized trans-ancestral Bayesian analysis to narrow down the location of the probable causal variant at each genome-wide significant signal. Of all the fine-mapped loci, we were able to narrow down the causative variant at four known loci to fewer than ten SNPs (FAIM2, GNPDA2, MC4R and SEC16B loci). In conclusion, an ethnically diverse setting has enabled us to both identify an additional pediatric obesity locus and further fine-map existing loci

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection

Volume and outcomes relationship in laparoscopic diaphragmatic hernia repair

BackgroundThere is no published data regarding the relationship between hospital volume and outcomes in patients undergoing laparoscopic diaphragmatic hernia repair. We hypothesize that hospitals performing high case volume have improved outcomes compared to low-volume hospitals.Materials and methodsWe reviewed the National Inpatient Sample (NIS) database between 2008 and 2012 for adults with the diagnosis of diaphragmatic hernia who underwent elective laparoscopic repair of diaphragmatic Hernia and/or Nissen fundoplication. Pediatric, emergent, and open cases were excluded. Main outcome measures included logistic regression analysis of factors predictive of in-hospital mortality and outcomes according to annual hospital case volume.ResultsA total of 31,228 laparoscopic diaphragmatic hernia operations were analyzed. The overall in-hospital mortality was 0.14%. Risk factors for higher in-hospital mortality included renal failure (AOR: 6.26; 95% CI: 2.48-15.78; p &lt; 0.001), age&gt;60 years (AOR: 5.06; 95% CI: 2.38-10.76; p &lt; 0.001), and CHF (AOR: 3.80; 95% CI: 1.39-10.38; p = 0.009) while an incremental increase in volume of 10 cases/year (AOR: 0.89; 95% CI: 0.81-0.98; p = 0.019) and diabetes (AOR: 0.34; 95% CI: 0.12-0.93; p = 0.036) decreases mortality. There was a small but significant inverse relationship between hospital case volume and mortality with a 10% reduction in adjusted odds of in-hospital mortality for every increase in 10 cases per year. Using 10 cases per year as the volume threshold, low-volume hospitals (≤10 cases/year) had almost a twofold higher mortality compared to high-volume hospitals (0.23 vs. 0.12%, respectively, p = 0.02).ConclusionsThere was a small but significant inverse relationship between the hospitals' case volume and mortality in laparoscopic diaphragmatic hernia repair