Borderline Ovarian Malignancies : A Single Institute Retrospective Study.

Background: Borderline ovarian tumors are histologically characterized as epithelial tumors with a stratified growth pattern but without destructive stromal invasion. Little is known about the histological subtypes and outcome, role of fertility sparing surgery and role of postoperative therapy in advanced stage in Indian scenario. While there is ample data in the world literature about this disease, prognosis in Indian patients is largely unknown due to dearth of studies in our setting. Objective: To study the demographic profile, clinical features, imaging, treatment and outcome of borderline ovarian tumors. Methods: This is a retrospective study of eighty seven patients with pathologically proven diagnosis of borderline ovarian tumor, diagnosed and treated from January 2006 to October 2011 at our institution. Most patients underwent surgical staging which incuded total abdominal hysterectomy and bilateral salphingo-oophorectomy, infracolic omentectomy, bilateral pelvic and para aortic lymphadenectomy. Young patients who had not completed their family underwent fertility sparing surgery. Patients with invasive metastatic implants received adjuvant chemotherapy. The outcome of these patients was correlated with stage, type of peritoneal implant, type of surgical procedure and with histological subtype. Results: At a median follow-up of 48 months, 100 percent survival was noted. One patient with stage III disease had recurrence. Conclusions: Borderline ovarian tumors occur at a younger age compared to invasive tumors. In patients with early stage disease who wish to preserve fertility, hysterectomy and contralateral oophorectomy are not necessary. Serous tumors occur at a younger age. They can be associated with invasive peritoneal implants and raised CA125 values. Majority of the serous tumors are bilateral and smaller in size compared to mucinous and endometroid tumors. Raised CA125 values did not correlate with the stage of disease. These patients have an excellent prognosis even in Indian scenario where majority of patients present with big ovarian masses

A study on medication adherence, medication related challenges faced and coping strategies adopted by visually impaired subjects in a tertiary care hospital

Background: Visual impairment poses a significant threat to proper medication practice leading to medication related challenges and some adopted self coping strategies with substantial impact on medication adherence. Visually impaired are potentially more likely to have unsafe medicine related practice which by itself is more rampant in general population. Studies related to them are largely unexplored and can provide data to improve disease management and health related quality of life. Objectives was to study the level of medication adherence, medication related challenges and self adopted coping strategies in visually impaired people.Methods: A cross sectional descriptive study enrolling 204 subjects with VI was done. Medication adherence was assessed using MMAS. Medication related challenges and self-adopted coping strategies was assessed by using pre-validated semi-structured questionnaire.Results: Majority of the subjects showed medium medication adherence with forgetfulness to take medicine as the main reason for non adherence. Difficulty in remembering the instructions, spilling of liquid medicine, taking wrong dose, difficulty in using topical medications were the most common challenges faced by them in daily drug administration. To overcome challenges locating the drugs at different places, finger felt volume for liquid medication, textural feeling of the drug or container, time tracking were the major self adopted coping strategies by the visually impaired subjects.Conclusions: Creating awareness of the medication related problem faced by visually impaired helps to provide adequate assistance to medication use and improve proper health care services in them

A Mathematical Model for Micropolar Fluid Flow Through an Artery with the effect of Stenosis and Post Stenotic Dilatation

The effects of both stenosis and post stenotic dilatation have been studied on steady flow of micropolar fluid through an artery. Assuming the stenosis to be mild, the equations governing the flow of the proposed model are solved. Closed form expressions for the flow characteristics such as velocity, pressure drop, and volumetric flow rate, resistance to the flow and wall shear stress are derived. The effects of various parameters on resistance to the flow and wall shear stress have been analyzed through the graphs. It is found that the resistance to the flow increases with the height and length of the stenosis, but the resistance to the flow decreases with stenotic dilatation. With the increase of the coupling number the resistance to the flow increases. However, the effect of coupling number is not very significant. The resistance to the flow decreases with the micropolar fluid parameter. The wall shear stress increases with coupling number and stenosis height, but it decreases with micropolar fluid parameter and stenotic dilatation

Diethyl 3,4-bis­(2,5-dimethoxy­benz­yl)thieno[2,3-b]thio­phene-2,5-di­car­boxylate

In the title compound, C30H32O8S2, the dihedral angle between the two benzene rings is 18.8 (1)°. The mol­ecular structure is stabilized by weak intra­molecular C—H⋯O hydrogen bonds. In the crystal structure, the mol­ecules are linked via weak inter­molecular C—H⋯O hydrogen bonds and π–π inter­actions between two benzene rings [centroid–centroid distance = 3.672 (1) Å]

Rigid endoscope-assisted tracheal intubation in a case of epiglottic cyst

Epiglottic cysts are of particular interest to both surgeons and anaesthetists because of the way in which they encroach on the airway. An epiglottic cyst in a 29-year-old woman was scheduled for endoscopic excision. It was located at the vallecula, and measured around 3 x 4 cm. As a fibre-optic bronchoscope was not available in our institution, endotracheal intubation was achieved with the help of a rigid endoscope and video-camera system.Keywords: epiglottic cyst, 300 nasal endoscope, nasotracheal intubatio

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin