547 research outputs found
On the cohomology of stable map spaces
We describe an approach to calculating the cohomology rings of stable map
spaces. The method we use is due to Akildiz-Carrell and employs a C^*-action
and a vector field which is equivariant with respect to this C^*-action. We
give an explicit description of the big Bialynicky-Birula cell of the
C^*-action on Mbar_00(P^n,d) as a vector bundle on Mbar_0d. This is used to
calculate explicitly the cohomology ring of Mbar_00(P^n,d) in the cases d=2 and
d=3. Of particular interest is the case as n approaches infinity.Comment: 63 page
Multimodal Neuroimaging-Informed Clinical Applications in Neuropsychiatric Disorders
Recent advances in neuroimaging data acquisition and analysis hold the promise to enhance the ability to make diagnostic and prognostic predictions and perform treatment planning in neuropsychiatric disorders. Prior research using a variety of types of neuroimaging techniques has confirmed that neuropsychiatric disorders are associated with dysfunction in anatomical and functional brain circuits. We first discuss current challenges associated with the identification of reliable neuroimaging markers for diagnosis and prognosis in mood disorders and for neurosurgical treatment planning for deep brain stimulation (DBS). We then present data on the use of neuroimaging for the diagnosis and prognosis of mood disorders and for DBS treatment planning. We demonstrate how multivariate analyses of functional activation and connectivity parameters can be used to differentiate patients with bipolar disorder from those with major depressive disorder and non-affective psychosis. We also present data on connectivity parameters that mediate acute treatment response in affective and non-affective psychosis. We then focus on precision mapping of functional connectivity in native space. We describe the benefits of integrating anatomical fiber reconstruction with brain functional parameters and cortical surface measures to derive anatomically-informed connectivity metrics within the morphological context of each individual brain. We discuss how this approach may be particularly promising in psychiatry, given the clinical and etiological heterogeneity of the disorders, and particularly in treatment response prediction and planning. Precision mapping of connectivity is essential for DBS. In DBS, treatment electrodes are inserted into positions near key grey matter nodes within the circuits considered relevant to disease expression. However, targeting white matter tracts that underpin connectivity within these circuits may increase treatment efficacy and tolerability therefore relevant for effective treatment. We demonstrate how this approach can be validated in the treatment of Parkinsonâs disease by identifying connectivity patterns that can be used as biomarkers for treatment planning and thus refine the traditional approach of DBS planning that uses only grey matter landmarks. Finally we describe how this approach could be used in planning DBS treatment of psychiatric disorders
Models of the Morphology, Kinematics, and Star Formation History of the Prototypical Collisional Starburst System: NGC 7714/7715 = Arp 284
(abridged) We present new N-body, hydrodynamical simulations of the
interaction between the starburst galaxy NGC 7714 and its post-starburst
companion NGC 7715, focusing on the formation of the collisional features,
including: 1) the gas-rich star forming bridge, 2) the large gaseous loop (and
stellar tails) to the west of the system, 3) the very extended HI tail to the
west and north of NGC 7714, and 4) the partial stellar ring in NGC 7714. Our
simulations confirm the results of earlier work that an off-center inclined
collision between two disk galaxies is almost certainly responsible for the
peculiar morphologies of this system. However, we have explored a wider set of
initial galaxy and collisional encounter parameters than previously, and have
found a relatively narrow range of parameters that reproduce all the major
morphologies of this system. The simulations suggest specific mechanisms for
the development of several unusual structures. We find that the complex gas
bridge has up to four distinct components, with gas contributed from two sides
of NGC 7715, as well as from NGC 7714. The observed gas-star offset in this
bridge is accounted for in the simulations by the dissipative evolution of the
gas. The models also indicate that the low surface brightness HI tail to the
far west of NGC 7714 is the end of the NGC 7715 countertail, curved behind the
two galaxies. Spectral evolutionary models of the NGC 7714 core by Lan\c{c}on
et al. suggest the possibility of multiple starbursts in the last 300 Myr. Our
hydrodynamic models suggest that bursts could be triggered by induced ring-like
waves, and a post-collision buildup of gas in the core of the galaxy.Comment: 24 pages, 20 figures, accepted for ApJ Supp
New Observations of Extra-Disk Molecular Gas in Interacting Galaxy Systems, Including a Two-Component System in Stephan's Quintet
We present new CO (1 - 0) observations of eleven extragalactic tails and
bridges in nine interacting galaxy systems, almost doubling the number of such
features with sensitive CO measurements. Eight of these eleven features were
undetected in CO to very low CO/HI limits, with the most extreme case being the
NGC 7714/5 bridge. This bridge contains luminous H II regions and has a very
high HI column density (1.6 X 10^21 cm^-2 in the 55" CO beam), yet was
undetected in CO to rms T(R)* = 2.4 mK. The HI column density is higher than
standard H2 and CO self-shielding limits for solar-metallicity gas, suggesting
that the gas in this bridge is metal-poor and has an enhanced N(H2)/I(CO) ratio
compared to the Galactic value. Only one of the eleven features in our sample
was unambiguously detected in CO, a luminous HI-rich star formation region near
an optical tail in the compact group Stephan's Quintet. We detect CO at two
widely separated velocities in this feature, at ~6000 km/s and ~6700 km/s. Both
of these components have HI and H-alpha counterparts. These velocities
correspond to those of galaxies in the group, suggesting that this gas is
material that has been removed from two galaxies in the group. The
CO/HI/H-alpha ratios for both components are similar to global values for
spiral galaxies.Comment: 39 pages, Latex, 15 figures, Astronomical Journal, in pres
Tense and aspect in word problems about motion: diagram, gesture, and the felt experience of time
© 2014, Mathematics Education Research Group of Australasia, Inc. Word problems about motion contain various conjugated verb forms. As students and teachers grapple with such word problems, they jointly operationalize diagrams, gestures, and language. Drawing on findings from a 3-year research project examining the social semiotics of classroom interaction, we show how teachers and students use gesture and diagram to make sense of complex verb forms in such word problems. We focus on the grammatical category of âaspectâ for how it broadens the concept of verb tense. Aspect conveys duration and completion or frequency of an event. The aspect of a verb defines its temporal flow (or lack thereof) and the location of a vantage point for making sense of this durational process
ISO observations of Hickson Compact Group 31 with the central Wolf-Rayet galaxy NGC 1741
Hickson Compact Group (HCG) 31, consisting of the Wolf-Rayet galaxy NGC 1741
and its irregular dwarf companions, was observed using the Infrared Space
Observatory. The deconvolved ISOCAM maps of the galaxies using the 7.7 micron
and 14.3 micron (LW6 and LW3) filters are presented, along with ISOPHOT
spectrometry of the central starburst region of NGC 1741 and the nucleus of
galaxy HCG 31A. Strong mid-IR emission was detected from the central burst in
NGC 1741, along with strong PAH features and a blend of features including [S
IV] at 10.5 micron. The 14.3/6.75 micron flux ratio, where the 6.75 micron flux
was synthesized from the PHT-S spectrum, and 14.3/7.7 micron flux ratios
suggest that the central burst within NGC 1741 may be moving towards the
post-starburst phase. Diagnostic tools including the ratio of the integrated
PAH luminosity to the 40 to 120 micron infrared luminosity and the far-infrared
colours reveal that despite the high surface brightness of the nucleus, the
properties of NGC 1741 can be explained in terms of a starburst and do not
require the presence of an AGN. The Tycho catalogue star TYC 04758-466-1, with
m = 11.3 and spectral type F6, was detected at 7.7 and 14.3 microns.Comment: 27 pages, 7 figures. Accepted for publication in the Astrophysical
Journa
The implausibility of âusual careâ in an open system: sedation and weaning practices in Paediatric Intensive Care Units (PICUs) in the United Kingdom (UK)
Background: The power of the randomised controlled trial depends upon its capacity to operate in a closed
system whereby the intervention is the only causal force acting upon the experimental group and absent in the
control group, permitting a valid assessment of intervention efficacy. Conversely, clinical arenas are open systems
where factors relating to context, resources, interpretation and actions of individuals will affect implementation and
effectiveness of interventions. Consequently, the comparator (usual care) can be difficult to define and variable in
multi-centre trials. Hence outcomes cannot be understood without considering usual care and factors that may
affect implementation and impact on the intervention.
Methods: Using a fieldwork approach, we describe PICU context, âusualâ practice in sedation and weaning from
mechanical ventilation, and factors affecting implementation prior to designing a trial involving a sedation and
ventilation weaning intervention. We collected data from 23 UK PICUs between June and November 2014 using
observation, individual and multi-disciplinary group interviews with staff.
Results: Pain and sedation practices were broadly similar in terms of drug usage and assessment tools. Sedation
protocols linking assessment to appropriate titration of sedatives and sedation holds were rarely used (9 % and 4 %
of PICUs respectively). Ventilator weaning was primarily a medical-led process with 39 % of PICUs engaging senior
nurses in the process: weaning protocols were rarely used (9 % of PICUs). Weaning methods were variably based
on clinician preference. No formal criteria or use of spontaneous breathing trials were used to test weaning
readiness. Seventeen PICUs (74 %) had prior engagement in multi-centre trials, but limited research nurse
availability. Barriers to previous trial implementation were intervention complexity, lack of belief in the evidence and
inadequate training. Facilitating factors were senior staff buy-in and dedicated research nurse provision.
Conclusions: We examined and identified contextual and organisational factors that may impact on the
implementation of our intervention. We found usual practice relating to sedation, analgesia and ventilator weaning
broadly similar, yet distinctively different from our proposed intervention, providing assurance in our ability to
evaluate intervention effects. The data will enable us to develop an implementation plan; considering these factors
we can more fully understand their impact on study outcomes
Compassion Stress and the Qualitative Researcher
Human subjects are carefully protected in the research process. However, the same consideration is not currently being given to the qualitative researcher, even those investigating topics that are likely to elicit powerful emotions. The role of researcherâs emotional responses and the self-care strategies that, in some circumstances, are appropriate for the researcher and other research support personnel have not received the attention they deserve in qualitative research literature. Based on experience in conducting research on the topic of self-directed learning and breast cancer, and on the limited literature available, the author makes the case for the use of strategies such as counseling, peer debriefing, and journal writing as means of dealing with the potential for âcompassion stressâ as experienced by the researcher and other research support personnel. She also suggests that the preparation of social science researchers should include information on appropriate self-care strategies.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline
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