APP Expression in Primary Neuronal Cell Cultures fromP6 Mice during in vitro Differentiation

Primary neuronal cell cultures from P6 mice were investigated in order to study amyloid protein precursor (APP) gene expression in differentiating neurons. Cerebellar granule cells which strongly express APP 695 allowed the identification of three distinct isoforms of neuronal APP 695. The high-molecular-weight form of APP 695 is sialylated. The expression pattern of neuronal APP 695 changes during in vitro differentiation. Sialylated forms become more abundant upon longer cultivation time. The secreted forms of sialylated, neuronal APP 695 are shown to comigrate with APP isolated from cerebrospinal fluid. We suggest that the different sialylation states of APP 695 may reflect the modulation of cell-cell and cell-substrate interactions during in vitro differentiation and regeneration

The 2MASS Tully-Fisher Survey : Mapping the Mass in the Universe

The 2MASS Tully-Fisher Survey (2MTF) aims to measure Tully-Fisher (TF) distances for all bright inclined spirals in the 2MASS Redshift Survey (2MRS) using high quality HI widths and 2MASS photometry. Compared with previous peculiar velocity surveys, the 2MTF survey provides more accurate width measurements and more uniform sky coverage, combining observations with the Green Bank, Arecibo and Parkes telescopes. With this new redshift-independent distance database, we will significantly improve our understanding of the mass distribution in the local universe.Comment: 4 pages, 3 figures, IAU Symposium 289 proceedin

Suprathermal electrons at Saturn's bow shock

The leading explanation for the origin of galactic cosmic rays is particle acceleration at the shocks surrounding young supernova remnants (SNRs), although crucial aspects of the acceleration process are unclear. The similar collisionless plasma shocks frequently encountered by spacecraft in the solar wind are generally far weaker (lower Mach number) than these SNR shocks. However, the Cassini spacecraft has shown that the shock standing in the solar wind sunward of Saturn (Saturn's bow shock) can occasionally reach this high-Mach number astrophysical regime. In this regime Cassini has provided the first in situ evidence for electron acceleration under quasi-parallel upstream magnetic conditions. Here we present the full picture of suprathermal electrons at Saturn's bow shock revealed by Cassini. The downstream thermal electron distribution is resolved in all data taken by the low-energy electron detector (CAPS-ELS, <28 keV) during shock crossings, but the higher energy channels were at (or close to) background. The high-energy electron detector (MIMI-LEMMS, >18 keV) measured a suprathermal electron signature at 31 of 508 crossings, where typically only the lowest energy channels (<100 keV) were above background. We show that these results are consistent with theory in which the "injection" of thermal electrons into an acceleration process involves interaction with whistler waves at the shock front, and becomes possible for all upstream magnetic field orientations at high Mach numbers like those of the strong shocks around young SNRs. A future dedicated study will analyze the rare crossings with evidence for relativistic electrons (up to ~1 MeV).Comment: 22 pages, 5 figures. Accepted for publication in Ap

HIghMass - High HI Mass, HI-Rich Galaxies at z∼0z\sim0: Combined HI and H2_2 Observations

We present resolved HI and CO observations of three galaxies from the HIghMass sample, a sample of HI-massive ($M_{HI} > 10^{10} M_\odot$), gas-rich ($M_{HI}$ in top $5\%$ for their $M_*$) galaxies identified in the ALFALFA survey. Despite their high gas fractions, these are not low surface brightness galaxies, and have typical specific star formation rates (SFR$/M_*$) for their stellar masses. The three galaxies have normal star formation rates for their HI masses, but unusually short star formation efficiency scale lengths, indicating that the star formation bottleneck in these galaxies is in the conversion of HI to H$_2$, not in converting H$_2$ to stars. In addition, their dark matter spin parameters ($\lambda$) are above average, but not exceptionally high, suggesting that their star formation has been suppressed over cosmic time but are now becoming active, in agreement with prior H$\alpha$ observations.Comment: 20 pages, 13 figure

Geometrical tests of cosmological models. II. Calibration of rotational widths and disc scaling relations

This series of papers is dedicated to a new technique to select galaxies that can act as standard rods and standard candles in order to perform geometrical tests on large samples of high redshift galaxies to constrain different cosmological parameters. The goals of this paper are (1) to compare different rotation indicators in order to understand the relation between rotation velocities extracted from observations of the Halpha line and the [OII]3727 line, and (2) determine the scaling relations between physical size, surface brightness and magnitude of galaxies and their rotation velocity using the SFI++, a large catalog of nearby galaxies observed at I-band. A good correlation is observed between the rotation curve-derived velocities of the Halpha and [OII] observations, as well as between those calculated from velocity histograms, justifying the direct comparison of velocities measured from Halpha rotation curves in nearby galaxies and from [OII] line widths at higher redshifts. To provide calibration for the geometrical tests, we give expressions for the different scaling relations between properties of galaxies (size, surface brightness, magnitude) and their rotation speeds. Apart from the Tully-Fisher relation, we derive the size-rotation velocity and surface brightness-rotation velocity relations with unprecedentedly small scatters. We show how the best size-rotation velocity relation is derived when size is estimated not from disc scale lengths but from the isophotal diameter r23.5, once these have been corrected for inclination and extinction effects.Comment: 14 pages and 10 figures. A&A submitte

The Scientific Study of Positive Psychology, Religion/Spirituality, and Physical Health

Humans have long been interested in relations among religion/spirituality (R/S), positive psychological constructs, and physical health. Furthermore, many religions attempt to influence behavior through health-related prescriptions about food choices, sexual activity, substance use, and resting. Similarly, positive psychological constructs have been discussed in light of their presumed benefits on both mental and physical health (Ryff & Singer, 1998). However, R/S and positive psychological constructs have only recently become objects of scientific investigation of their associations with physical health.https://digitalcommons.chapman.edu/psychology_books/1025/thumbnail.jp

SDSS IV MaNGA: Dependence of Global and Spatially Resolved SFR-M ∗ Relations on Galaxy Properties

Indexación: Scopus.The galaxy integrated Hα star formation rate-stellar mass relation, or SFR(global)-M ∗(global) relation, is crucial for understanding star formation history and evolution of galaxies. However, many studies have dealt with SFR using unresolved measurements, which makes it difficult to separate out the contamination from other ionizing sources, such as active galactic nuclei and evolved stars. Using the integral field spectroscopic observations from SDSS-IV MaNGA, we spatially disentangle the contribution from different Hα powering sources for ∼1000 galaxies. We find that, when including regions dominated by all ionizing sources in galaxies, the spatially resolved relation between Hα surface density (ΣHα(all)) and stellar mass surface density (Σ∗(all)) progressively turns over at the high Σ∗(all) end for increasing M ∗(global) and/or bulge dominance (bulge-to-total light ratio, B/T). This in turn leads to the flattening of the integrated Hα(global)-M ∗(global) relation in the literature. By contrast, there is no noticeable flattening in both integrated Hα(H ii)-M ∗(H ii) and spatially resolved ΣHα(H ii)-Σ∗(H ii) relations when only regions where star formation dominates the ionization are considered. In other words, the flattening can be attributed to the increasing regions powered by non-star-formation sources, which generally have lower ionizing ability than star formation. An analysis of the fractional contribution of non-star-formation sources to total Hα luminosity of a galaxy suggests a decreasing role of star formation as an ionizing source toward high-mass, high-B/T galaxies and bulge regions. This result indicates that the appearance of the galaxy integrated SFR-M ∗ relation critically depends on their global properties (M ∗(global) and B/T) and relative abundances of various ionizing sources within the galaxies.http://iopscience.iop.org/article/10.3847/1538-4357/aaa9bc/met