46,453 research outputs found
Putting it All Together: Agreement, Incorporation, Coordination and External Possession in Wubuy (Australia)
In this paper we examine the interaction of a number of grammatical phenomena in Wubuy, a polysynthetic language from northern Australia, and show how they can be given a comprehensive analysis within the framework of LFG. While each of these phenomena ? noun incorporation, verbal agreement, coordination and external possession ? has received various treatments within the LFG literature, no one study has addressed the compatibility of these analyses under interaction, despite the fact that they frequently co-occur in the world?s languages. We use data from Wubuy to showcase the effects of this interaction, and investigate the implications for LFG and for LFG analyses of polysynthetic languages more generally
Macroscopic limits of individual-based models for motile cell populations with volume exclusion
Partial differential equation models are ubiquitous in studies of motile cell populations, giving a phenomenological description of events which can be analyzed and simulated using a wide range of existing tools. However, these models are seldom derived from individual cell behaviors and so it is difficult to accurately include biological hypotheses on this spatial scale. Moreover, studies which do attempt to link individual- and population-level behavior generally employ lattice-based frameworks in which the artifacts of lattice choice at the population level are unclear. In this work we derive limiting population-level descriptions of a motile cell population from an off-lattice, individual-based model (IBM) and investigate the effects of volume exclusion on the population-level dynamics. While motility with excluded volume in on-lattice IBMs can be accurately described by Fickian diffusion, we demonstrate that this is not the case off lattice. We show that the balance between two key parameters in the IBM (the distance moved in one step and the radius of an individual) determines whether volume exclusion results in enhanced or slowed diffusion. The magnitude of this effect is shown to increase with the number of cells and the rate of their movement. The method we describe is extendable to higher-dimensional and more complex systems and thereby provides a framework for deriving biologically realistic, continuum descriptions of motile populations
Lebowitz Inequalities for Ashkin-Teller Systems
We consider the Ashkin-Teller model with negative four-spin coupling but
still in the region where the ground state is ferromagnetic. We establish the
standard Lebowitz inequality as well as the extension that is necessary to
prove a divergent susceptibility.Comment: Ams-TeX, 12 pages; two references added, final version accepted for
publication in Physica
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Nickel-catalyzed transamidation of aliphatic amide derivatives.
Transamidation, or the conversion of one amide to another, is a long-standing challenge in organic synthesis. Although notable progress has been made in the transamidation of primary amides, the transamidation of secondary amides has remained underdeveloped, especially when considering aliphatic substrates. Herein, we report a two-step approach to achieve the transamidation of secondary aliphatic amides, which relies on non-precious metal catalysis. The method involves initial Boc-functionalization of secondary amide substrates to weaken the amide C-N bond. Subsequent treatment with a nickel catalyst, in the presence of an appropriate amine coupling partner, then delivers the net transamidated products. The transformation proceeds in synthetically useful yields across a range of substrates. A series of competition experiments delineate selectivity patterns that should influence future synthetic design. Moreover, the transamidation of Boc-activated secondary amide derivatives bearing epimerizable stereocenters underscores the mildness and synthetic utility of this methodology. This study provides the most general solution to the classic problem of secondary amide transamidation reported to date
Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of ß-Lactamase-Producing Escherichia coli
Reversal of antimicrobial resistance is an appealing and largely unexplored strategy in drug discovery. The objective of this study was to identify potential targets for “helper” drugs reversing cephem resistance in Escherichia coli strains producing β-lactamases. A CMY-2-encoding plasmid was transferred by conjugation to seven isogenic deletion mutants exhibiting cephem hypersusceptibility. The effect of each mutation was evaluated by comparing the MICs in the wild type and the mutant harboring the same plasmid. Mutation of two genes encoding proteins involved in cell wall biosynthesis, dapF and mrcB, restored susceptibility to cefoxitin (FOX) and reduced the MICs of cefotaxime and ceftazidime, respectively, from the resistant to the intermediate category according to clinical breakpoints. The same mutants harboring a CTX-M-1-encoding plasmid fell into the intermediate or susceptible category for all three drugs. Individual deletion of dapF and mrcB in a clinical isolate of CTX-M-15-producing E. coli sequence type 131 (ST131) resulted in partial reversal of ceftazidime and cefepime resistance but did not reduce MICs below susceptibility breakpoints. Growth curve analysis indicated no fitness cost in a ΔmrcB mutant, whereas a ΔdapF mutant had a 3-fold longer lag phase than the wild type, suggesting that drugs targeting DapF may display antimicrobial activity, in addition to synergizing with selected cephems. DapF appeared to be a potential FOX helper drug target candidate, since dapF inactivation resulted in synergistic potentiation of FOX in the genetic backgrounds tested. The study showed that individual inactivation of two nonessential genes involved in cell wall biogenesis potentiates cephem activity according to drug- and strain-specific patterns
Conference on Automated Decision-Making and Problem Solving, the Third Day: Issues Discussed
A conference held at Langley Research Center in May of 1980 brought together university experts from the fields of Control Theory, Operations Research, and Artificial Intelligence to explore current research in automation from both the perspective of their own particular disciplines and from that of interdisciplinary considerations. Informal discussions from the final day of the those day conference are summarized
Image Ellipticity from Atmospheric Aberrations
We investigate the ellipticity of the point-spread function (PSF) produced by
imaging an unresolved source with a telescope, subject to the effects of
atmospheric turbulence. It is important to quantify these effects in order to
understand the errors in shape measurements of astronomical objects, such as
those used to study weak gravitational lensing of field galaxies. The PSF
modeling involves either a Fourier transform of the phase information in the
pupil plane or a ray-tracing approach, which has the advantage of requiring
fewer computations than the Fourier transform. Using a standard method,
involving the Gaussian weighted second moments of intensity, we then calculate
the ellipticity of the PSF patterns. We find significant ellipticity for the
instantaneous patterns (up to more than 10%). Longer exposures, which we
approximate by combining multiple (N) images from uncorrelated atmospheric
realizations, yield progressively lower ellipticity (as 1 / sqrt(N)). We also
verify that the measured ellipticity does not depend on the sampling interval
in the pupil plane using the Fourier method. However, we find that the results
using the ray-tracing technique do depend on the pupil sampling interval,
representing a gradual breakdown of the geometric approximation at high spatial
frequencies. Therefore, ray tracing is generally not an accurate method of
modeling PSF ellipticity induced by atmospheric turbulence unless some
additional procedure is implemented to correctly account for the effects of
high spatial frequency aberrations. The Fourier method, however, can be used
directly to accurately model PSF ellipticity, which can give insights into
errors in the statistics of field galaxy shapes used in studies of weak
gravitational lensing.Comment: 9 pages, 5 color figures (some reduced in size). Accepted for
publication in the Astrophysical Journa
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