Outgassing measurement of the aluminum alloy UHV chamber

A large vacuum chamber (580 mm diameter) was fabricated from an aluminum alloy surface treated by a special process normally used on small chambers. The chamber was tested unbaked and baked at various temperatures, pressures, and holding periods. The chamber was filled with N2 gas, and the outgassing rate was measured after one hour. Then the ultimate pressure was measured. Outgassing rates for baked and unbaked groups were compared. It is concluded that the same surface treatment technique can be used on both large and small chambers produced by the same special extrusion process

Oral vinorelbine and cisplatin with concomitant radiotherapy in stage III non-small cell lung cancer (NSCLC): A feasibility study

Background: Concurrent chemoradiotherapy has improved survival in inoperable stage III non-small cell lung cancer (NSCLC). This phase I trial was performed in order to establish a dose recommendation for oral vinorelbine in combination with cisplatin and simultaneous radiotherapy. Patients and Methods: Previously untreated patients with stage IIIB NSCLC received concurrent chemoradiotherapy with 66 Gy and 2 cycles of cisplatin and oral vinorelbine which was administered at 3 different levels (40, 50 and 60 mg/m(2)). This was to be followed by 2 cycles of cisplatin/vinorelbine oral consolidation chemotherapy. The study goal was to determine the maximal recommended dose of oral vinorelbine during concurrent treatment. Results: 11 stage IIIB patients were entered into the study. The median radiotherapy dose was 66 Gy. Grade 3-4 toxicity included neutropenia, esophagitis, gastritis and febrile neutropenia. The dose-limiting toxicity for concurrent chemoradiotherapy was esophagitis. 9 patients received consolidation chemotherapy, with neutropenia and anemia/thrombocytopenia grade 3 being the only toxicities. The overall response was 73%. Conclusion: Oral vinorelbine 50 mg/m(2) (days 1, 8, 15 over 4 weeks) in combination with cisplatin 20 mg/m2 (days 1-4) is the recommended dose in combination with radiotherapy (66 Gy) and will be used for concurrent chemoradiotherapy in a forthcoming phase III trial testing the efficacy of consolidation chemotherapy in patients not progressing after chemoradiotherapy

Simulations of Protoplanetary Disk Dispersal: Stellar Mass Dependence of the Disk Lifetime

Recent infrared and submillimeter observations suggest that the protoplanetary disk lifetime depends on the central stellar mass. The disk dispersal is thought to be driven by viscous accretion, magneto-hydrodynamics (MHD) winds, and photoevaporation by the central star. We perform a set of one-dimensional simulations of long-term disk evolution that include all the three processes. We vary the stellar mass in the range of 0.5-7M$_{\odot}$, and study the mass dependence of the disk evolution. We show that a significant fraction of the disk gas is lost by MHD winds in the early stage, but the later disk evolution is mainly governed by photoevaporation. The disk radius decreases as photoevaporation clears out the gas in the outer disk efficiently. The qualitative evolutionary trends of the disk mass are remarkably similar for the wide range of the central stellar mass we consider, and the time evolution of the disk mass can be well fitted by a simple function. The dispersal time is approximately ten million years for low mass stars with weak mass dependence, but gets as short as two million years around a 7M$_{\odot}$ star. In the latter case, a prominent inner hole is formed by the combined effect of accretion and MHD winds within about one million years. The strength of the MHD wind and viscous accretion controls the overall mass-loss rate, but does not alter the dependence of the dispersal timescale on the central stellar mass.Comment: 14 pages, 10 figures, 1 tabl

Privacy issues and protection in secure data outsourcing

Utilizing database encryption to safeguard data in several conditions where access control is not sufficient is unavoidable. Database encryption offers an extra layer of security to traditional access control methods. It stops users that are unauthorized, such as hackers breaking into a system, and observing private data. Consequently, data is safe even when the database is stolen or attacked. Nevertheless, the process of data decryption and encryption causes degradation in the database performance. In conditions where the entire information is kept in an encrypted format, it is not possible to choose the database content any longer. The data must be first decrypted, and as such, the unwilling and forced tradeoff occurs between the function and the security. The suitable methods to improve the function are techniques that directly deal with the data that is encrypted without having to decrypt them first. In this study, we determined privacy protection and issues that each organization should consider when it decides to outsource own data

Channeling Effects in Direct Dark Matter Detectors

The channeling of the ion recoiling after a collision with a WIMP changes the ionization signal in direct detection experiments, producing a larger signal than otherwise expected. We give estimates of the fraction of channeled recoiling ions in NaI (Tl), Si and Ge crystals using analytic models produced since the 1960's and 70's to describe channeling and blocking effects. We find that the channeling fraction of recoiling lattice nuclei is smaller than that of ions that are injected into the crystal and that it is strongly temperature dependent.Comment: 8 pages, 12 figures, To appear in the Proceedings of the sixth International Workshop on the Dark Side of the Universe (DSU2010) Leon, Guanajuato, Mexico 1-6 June 201

Motion-Induced Magnetic Resonance of Rb Atoms in a Periodic Magnetostatic Field

We demonstrate that transitions between Zeeman-split sublevels of Rb atoms are resonantly induced by the motion of the atoms (velocity: about 100 m/s) in a periodic magnetostatic field (period: 1 mm) when the Zeeman splitting corresponds to the frequency of the magnetic field experienced by the moving atoms. A circularly polarized laser beam polarizes Rb atoms with a velocity selected using the Doppler effect and detects their magnetic resonance in a thin cell, to which the periodic field is applied with the arrays of parallel current-carrying wires.Comment: 4 pages, 4 figures; minor corrections, Ref. [9] removed, published in PR

The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission

1Infection of red blood cells (RBC) subjects the malaria parasite to oxidative stress. Therefore, efficient antioxidant and redox systems are required to prevent damage by reactive oxygen species. Plasmodium spp. have thioredoxin and glutathione (GSH) systems that are thought to play a major role as antioxidants during blood stage infection. In this report, we analyzed a critical component of the GSH biosynthesis pathway using reverse genetics. Plasmodium berghei parasites lacking expression of gamma-glutamylcysteine synthetase (γ-GCS), the rate limiting enzyme in de novo synthesis of GSH, were generated through targeted gene disruption thus demonstrating, quite unexpectedly, that γ-GCS is not essential for blood stage development. Despite a significant reduction in GSH levels, blood stage forms of pbggcs− parasites showed only a defect in growth as compared to wild type. In contrast, a dramatic effect on development of the parasites in the mosquito was observed. Infection of mosquitoes with pbggcs− parasites resulted in reduced numbers of stunted oocysts that did not produce sporozoites. These results have important implications for the design of drugs aiming at interfering with the GSH redox-system in blood stages and demonstrate that de novo synthesis of GSH is pivotal for development of Plasmodium in the mosquito