133 research outputs found
Resource Planning in Engineering Services Firms
We develop a model to enable engineering professional services firms to improve the management of their competitive resources, i.e., skilled engineers, to be better able to respond to customer demand. The model was informed by semistructured interviews with senior executives from engineering, information technology (IT) services and technical consulting firms. As a result, we capture many of the complexities associated with the resource planning process in the professional engineering services sector. In the resulting model, the key attributes of supply, demand, and operations constraints are identified. Based on information obtained from the interviews, a number of test firms are created.We then use these test firms to study the impact of various resource planning policies on firm performance. These policies include the skill mix and profile of skilled employees, limits on the number of concurrent projects to which an employee can be assigned, and policies governing employee cross-training and hiring. The impact of these policies is evaluated in terms of business metrics, such as the project completion rate and net revenue. Finally, our model is extended to capture a multiphase rolling planning horizon, where projects may span multiple phases with the goal of ensuring consistency in employee assignment to projects
(R)-4-Phenyl-2-[(S)-1,2,3,4-tetrahydroisoquinolin-3-yl]-4,5-dihydro-1,3-oxazole
The asymmetric unit cell of the title compound, C18H18N2O, contains four molecules. In the crystal structure, an intermolecular N—H⋯N hydrogen bond helps to establish the packing
Catalytic Enantioselective Cross-Couplings of Secondary Alkyl Electrophiles with Secondary Alkylmetal Nucleophiles: Negishi Reactions of Racemic Benzylic Bromides with Achiral Alkylzinc Reagents
We have developed a nickel-catalyzed method for the asymmetric cross-coupling of secondary electrophiles with secondary nucleophiles, specifically, stereoconvergent Negishi reactions of racemic benzylic bromides with achiral cycloalkylzinc reagents. In contrast to most previous studies of enantioselective Negishi cross-couplings, tridentate pybox ligands are ineffective in this process; however, a new, readily available bidentate isoquinoline–oxazoline ligand furnishes excellent ee’s and good yields. The use of acyclic alkylzinc reagents as coupling partners led to the discovery of a highly unusual isomerization that generates a significant quantity of a branched cross-coupling product from an unbranched nucleophile
Position paper on screening for breast cancer by the European Society of Breast Imaging (EUSOBI) and 30 national breast radiology bodies from Austria, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Israel, Lithuania, Moldova, The Netherlands, Norway, Poland, Portugal, Romania, Serbia, Slovakia, Spain, Sweden, Switzerland and Turkey.
UNLABELLED: EUSOBI and 30 national breast radiology bodies support mammography for population-based screening, demonstrated to reduce breast cancer (BC) mortality and treatment impact. According to the International Agency for Research on Cancer, the reduction in mortality is 40 % for women aged 50-69 years taking up the invitation while the probability of false-positive needle biopsy is <1 % per round and overdiagnosis is only 1-10 % for a 20-year screening. Mortality reduction was also observed for the age groups 40-49 years and 70-74 years, although with "limited evidence". Thus, we firstly recommend biennial screening mammography for average-risk women aged 50-69 years; extension up to 73 or 75 years, biennially, is a second priority, from 40-45 to 49 years, annually, a third priority. Screening with thermography or other optical tools as alternatives to mammography is discouraged. Preference should be given to population screening programmes on a territorial basis, with double reading. Adoption of digital mammography (not film-screen or phosphor-plate computer radiography) is a priority, which also improves sensitivity in dense breasts. Radiologists qualified as screening readers should be involved in programmes. Digital breast tomosynthesis is also set to become "routine mammography" in the screening setting in the next future. Dedicated pathways for high-risk women offering breast MRI according to national or international guidelines and recommendations are encouraged. KEY POINTS: • EUSOBI and 30 national breast radiology bodies support screening mammography. • A first priority is double-reading biennial mammography for women aged 50-69 years. • Extension to 73-75 and from 40-45 to 49 years is also encouraged. • Digital mammography (not film-screen or computer radiography) should be used. • DBT is set to become "routine mammography" in the screening setting in the next future
Resource Planning in Engineering Services Firms
We develop a model to enable engineering professional services firms to improve the management of their competitive resources, i.e., skilled engineers, to be better able to respond to customer demand. The model was informed by semistructured interviews with senior executives from engineering, information technology (IT) services and technical consulting firms. As a result, we capture many of the complexities associated with the resource planning process in the professional engineering services sector. In the resulting model, the key attributes of supply, demand, and operations constraints are identified. Based on information obtained from the interviews, a number of test firms are created.We then use these test firms to study the impact of various resource planning policies on firm performance. These policies include the skill mix and profile of skilled employees, limits on the number of concurrent projects to which an employee can be assigned, and policies governing employee cross-training and hiring. The impact of these policies is evaluated in terms of business metrics, such as the project completion rate and net revenue. Finally, our model is extended to capture a multiphase rolling planning horizon, where projects may span multiple phases with the goal of ensuring consistency in employee assignment to projects
Digital Twin for Human–Robot Collaboration in Manufacturing: Review and Outlook
Industry 4.0, as an enabler of smart factories, focuses on flexible automation and customization of products by utilizing technologies such as the Internet of Things and cyber–physical systems. These technologies can also support the creation of virtual replicas which exhibit real-time characteristics of a physical system. These virtual replicas are commonly referred to as digital twins. With the increased adoption of digitized products, processes and services across manufacturing sectors, digital twins will play an important role throughout the entire product lifecycle. At the same time, collaborative robots have begun to make their way onto the shop floor to aid operators in completing tasks through human–robot collaboration. Therefore, the focus of this paper is to provide insights into approaches used to create digital twins of human–robot collaboration and the challenges in developing these digital twins. A review of different approaches for the creation of digital twins is presented, and the function and importance of digital twins in human–robot collaboration scenarios are described. Finally, the paper discusses the challenges of creating a digital twin, in particular the complexities of modelling the digital twin of human–robot collaboration and the exactness of the digital twin with respect to the physical system
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