THE DISTRIBUTION OF BENEFITS RESULTING FROM BIOTECHNOLOGY ADOPTION

The purposes of this study are two-fold: (1) to estimate the size of total benefits arising from the adoption of agricultural biotechnology, and (2) to measure the distribution of total benefits among key stakeholders along the production and marketing chain, including U.S. farmers, gene developers, germplasm suppliers, U.S. consumers, and the producers and consumers in the rest of the world. This study focuses on the benefits that resulted from the adoption of herbicide-tolerant soybeans as well as insect-resistant (Bt) and herbicide-tolerant cotton in 1997. In this analysis, various data sources are examined for measuring the farm-level effects of adopting biotechnology and the resulting benefit estimates are compared. The size and distribution of the benefits arising from the adoption of biotech crops vary significantly, depending on the farm-level effects obtained from the various data sources and the supply and demand elasticity assumptions for the domestic and world markets. Estimates of the benefits derived from farm-level impacts that isolate the effects biotechnology appear to be the most plauible. This study does not lend support to the popular belief that U.S. farmers received at least one-half, or as much as two-thirds, of the total benefits realized from the adoption of biotechnology. In contrast, the results of this study indicate that in 1997, U.S. farmers realized considerably less than half of the total benefits. The bulk of the benefits appear to have gone to the gene supplier, seed companies, U.S. consumers, and the rest of the world.Research and Development/Tech Change/Emerging Technologies,

Comparison of Low-Thrust Control Laws for Application in Planetocentric Space

Recent interest at NASA for the application of solar electric propulsion for the transfer of significant payloads in cislunar space has led to the development of high-fidelity simulations of such missions. With such transfers involving transfer times on the order of months, simulation time can be significant. In the past, the examination of such missions typically began with the use of lower-fidelity trajectory optimization tools such as SEPSPOT to develop and tune guidance laws which delivered optimal or near- optimal trajectories, where optimal is generally defined as minimizing propellant expenditure or time of flight. The transfer of these solutions to a high-fidelity simulation is typically an iterative process whereby the initial solution may nearly, but not precisely, meet mission objectives. Further tuning of the guidance algorithm is typically necessary when accounting for high-fidelity perturbations such as those due to more detailed gravity models, secondary-body effects, solar radiation pressure, etc. While trajectory optimization is a useful method for determining optimal performance metrics, algorithms which deliver nearly optimal performance with minimal tuning are an attractive alternative

The Nordic Seas carbon budget: Sources, sinks, and uncertainties

A carbon budget for the Nordic Seas is derived by combining recent inorganic carbon data from the CARINA database with relevant volume transports. Values of organic carbon in the Nordic Seas' water masses, the amount of carbon input from river runoff, and the removal through sediment burial are taken from the literature. The largest source of carbon to the Nordic Seas is the Atlantic Water that enters the area across the Greenland-Scotland Ridge; this is in particular true for the anthropogenic CO2. The dense overflows into the deep North Atlantic are the main sinks of carbon from the Nordic Seas. The budget show that presently 12.3 ± 1.4 Gt C yr−1 is transported into the Nordic Seas and that 12.5 ± 0.9 Gt C yr−1 is transported out, resulting in a net advective carbon transport out of the Nordic Seas of 0.17 ± 0.06 Gt C yr−1. Taking storage into account, this implies a net air-to-sea CO2 transfer of 0.19 ± 0.06 Gt C yr−1 into the Nordic Seas. The horizontal transport of carbon through the Nordic Seas is thus approximately two orders of magnitude larger than the CO2 uptake from the atmosphere. No difference in CO2 uptake was found between 2002 and the preindustrial period, but the net advective export of carbon from the Nordic Seas is smaller at present due to the accumulation of anthropogenic CO2

Trajectory Optimization: OTIS 4

The latest release of the Optimal Trajectories by Implicit Simulation (OTIS4) allows users to simulate and optimize aerospace vehicle trajectories. With OTIS4, one can seamlessly generate optimal trajectories and parametric vehicle designs simultaneously. New features also allow OTIS4 to solve non-aerospace continuous time optimal control problems. The inputs and outputs of OTIS4 have been updated extensively from previous versions. Inputs now make use of objectoriented constructs, including one called a metastring. Metastrings use a greatly improved calculator and common nomenclature to reduce the user s workload. They allow for more flexibility in specifying vehicle physical models, boundary conditions, and path constraints. The OTIS4 calculator supports common mathematical functions, Boolean operations, and conditional statements. This allows users to define their own variables for use as outputs, constraints, or objective functions. The user-defined outputs can directly interface with other programs, such as spreadsheets, plotting packages, and visualization programs. Internally, OTIS4 has more explicit and implicit integration procedures, including high-order collocation methods, the pseudo-spectral method, and several variations of multiple shooting. Users may switch easily between the various methods. Several unique numerical techniques such as automated variable scaling and implicit integration grid refinement, support the integration methods. OTIS4 is also significantly more user friendly than previous versions. The installation process is nearly identical on various platforms, including Microsoft Windows, Apple OS X, and Linux operating systems. Cross-platform scripts also help make the execution of OTIS and post-processing of data easier. OTIS4 is supplied free by NASA and is subject to ITAR (International Traffic in Arms Regulations) restrictions. Users must have a Fortran compiler, and a Python interpreter is highly recommended

Endomyocardial, intralymphocyte, and whole blood concentrations of ciclosporin A in heart transplant recipients

BACKGROUND: In the early phases following heart transplantation a main challenge is to reduce the impact of acute rejections. Previous studies indicate that intracellular ciclosporin A (CsA) concentration may be a sensitive acute rejection marker in renal transplant recipients. The aims of this study were to evaluate the relationships between CsA concentrations at different target sites as potential therapeutic drug monitoring (TDM) tools in heart transplant recipients. METHODS: Ten heart transplant recipients (8 men, 2 women) on CsA-based immunosuppression were enrolled in this prospective single-center pilot study. Blood samples were obtained once to twice weekly up to 12 weeks post-transplant. One of the routine biopsies was allocated to this study at each sampling time. Whole blood, intralymphocyte, and endomyocardial CsA concentrations were determined with validated HPLC-MS/MS-methods. Mann–Whitney U test was used when evaluating parameters between the two groups of patients. To correlate whole blood, intralymphocyte, and endomyocardial CsA concentrations linear regression analysis was used. RESULTS: Three patients experienced mild rejections. In the study period, the mean (range) intralymphocyte CsA trough concentrations were 10.1 (1.5 to 39) and 8.1 (1.3 to 25) ng/10(6) cells in the rejection and no-rejection group, respectively (P=0.21). Corresponding whole blood CsA concentrations were 316 (153 to 564) and 301 (152 to 513) ng/mL (P=0.33). There were no correlations between whole blood, intralymphocyte, or endomyocardial concentrations of CsA (P >0.11). CONCLUSIONS: The study did not support an association between decreasing intralymphocyte CsA concentrations and acute rejections. Further, there were no association between blood concentrations and concentrations at sites of action, potentially challenging TDM in these patients

Nonminimal Supersymmetric Standard Model with Baryon and Lepton Number Violation

We carry out a comprehensive analysis of the nonminimal supersymmetric standard model (NMSSM) with baryon and lepton number violation. We catalogue the baryon and lepton number violating dimension four and five operators of the model. We then study the renormalization group evolution and infrared stable fixed points of the Yukawa couplings and the soft supersymmetry breaking trilinear couplings of this model with baryon and lepton number (and R-parity) violation involving the heaviest generations. We show analytically that in the Yukawa sector of the NMSSM there is only one infrared stable fixed point. This corresponds to a non-trivial fixed point for the top-, bottom-quark Yukawa couplings and the $B$ violating coupling $\lambda_{233}''$, and a trivial one for all other couplings. All other possible fixed points are either unphysical or unstable in the infrared region. We also carry out an analysis of the renormalization group equations for the soft supersymmetry breaking trilinear couplings, and determine the corresponding fixed points for these couplings. We then study the quasi-fixed point behaviour, both of the third generation Yukawa couplings and the baryon number violating coupling, and those of the soft supersymmetry breaking trilinear couplings. From the analysis of the fixed point behaviour, we obtain upper and lower bounds on the baryon number violating coupling $\lambda_{233}''$, as well as on the soft supersymmetry breaking trilinear couplings. Our analysis shows that the infrared fixed point behavior of NMSSM with baryon and lepton number violation is similar to that of MSSM.Comment: 35 pages, Revtex, 6 eps fig

A Precision Calculation of the Next-to-Leading Order Energy-Energy Correlation Function

The O(alpha_s^2) contribution to the Energy-Energy Correlation function (EEC) of e+e- -> hadrons is calculated to high precision and the results are shown to be larger than previously reported. The consistency with the leading logarithm approximation and the accurate cancellation of infrared singularities exhibited by the new calculation suggest that it is reliable. We offer evidence that the source of the disagreement with previous results lies in the regulation of double singularities.Comment: 6 pages, uuencoded LaTeX and one eps figure appended Complete paper as PostScript file (125 kB) available at: http://www.phys.washington.edu/~clay/eecpaper1/paper.htm

Polaronic optical absorption in electron-doped and hole-doped cuprates

Polaronic features similar to those previously observed in the photoinduced spectra of cuprates have been detected in the reflectivity spectra of chemically doped parent compounds of high-critical-temperature superconductors, both $n$-type and $p$-type. In Nd$_2$CuO$_{4-y}$ these features, whose intensities depend both on doping and temperature, include local vibrational modes in the far infrared and a broad band centered at $\sim$ 1000 cm$^{-1}$. The latter band is produced by the overtones of two (or three) local modes and is well described in terms of a small-polaron model, with a binding energy of about 500 cm$^{-1}$. Most of the above infrared features are shown to survive in the metallic phase of Nd$_{2-x}$Ce$_x$Cu0$_{4-y}$, Bi$_2$Sr$_2$CuO$_6$, and YBa$_2$Cu$_3$O$_{7-y}$, where they appear as extra-Drude peaks. The occurrence of polarons is attributed to local modes strongly coupled to carriers, as shown by a comparison with tunneling results.Comment: File latex, 31 p., submitted to Physical Review B. Figures may be faxed upon reques

Gauged Lifshitz scalar field theories in two dimensions

We present two-dimensional gauged Lifshitz scalar field theories by considering the duality relation between the source current and the Noether current. Requiring the duality partially, we obtain a gauged model which recovers the bosonized Schwinger model for the IR limit. For the exact duality, however, the source current is not conserved, which means that the resulting theory is anomalous, so that the number of degrees of freedom is increased. The second model is consistently formulated by adding the Wess-Zumino type action to maintain the gauge invariance.Comment: 11 page

Polaron Formation in the Three-Band Peierls-Hubbard Model for Cuprate Superconductors

Exact diagonalization calculations show a continuous transition from delocalized to small polaron behavior as a function of intersite electron-lattice coupling. A transition, found previously at Hartree-Fock level [Yonemitsu et al., Phys. Rev. Lett. {\bf 69}, 965 (1992)], between a magnetic and a non magnetic state does not subsist when fluctuations are included. Local phonon modes become softer close to the polaron and by comparison with optical measurements of doped cuprates we conclude that they are close to the transition region between polaronic and non-polaronic behavior. The barrier to adiabatically move a hole vanishes in that region suggesting large mobilities.Comment: 7 pages + 3 poscript figures, Revtex 3.0, MSC-199