ПОЛУЧЕНИЕ НИКЕЛЬ-КОБАЛЬТОВОГО КОНЦЕНТРАТА ПРИ ПЕРЕРАБОТКЕ РЕНИЙСОДЕРЖАЩЕГО ЖАРОПРОЧНОГО СПЛАВА

The article describes the results of HAS32-VI superalloy electrochemical processing in nitric acid solutions in galvanostatic mode. Experiments were conducted for electrochemical dissolution of HAS32-VI superalloy in galvanostatic mode using nitric acid with a concentration of 100 g/l at different values of anode current density. It is found that this leads to quantitative separation of superalloy HAS32-VI components. The anode slurry is the concentrate of refractory metals – niobium, tantalum, molybdenum and tungsten. Cobalt, rhenium and the principal amount of aluminum, chromium and nickel partially pass into electrolyte. The flow diagram of HAS32-VI superalloy processing was suggested that provides for generation and separation of the principal nickel and cobalt amount at the first stage with the formation of Ni–Co-containing metal sediment.Изложены результаты электрохимической переработки жаропрочного сплава марки ЖС32-ВИ, реализованной в гальваностатическом режиме в азотнокислом электролите. Проведены эксперименты по электрохимическому растворению в гальваностатическом режиме этого сплава с использованием раствора азотной кислоты с концентрацией 100 г/л при различных значениях плотности тока. Показано, что происходит количественное разделение составляющих его компонентов: в анодном шламе концентрируются тугоплавкие металлы – ниобий, тантал, молибден и вольфрам, а в электролит переходят частично кобальт и рений и основное количество алюминия, хрома и никеля. Предложена принципиальная технологическая схема переработки сплава ЖС32-ВИ, в которой получение и отделение основной массы никеля и кобальта осуществляются на первой стадии, с формированием металлического Ni–Co-содержащего осадка

COMPREHENSIVE OVERVIEW OF ADAPTOR PROTEIN RUK/CIN85 ROLES IN CANCER

Aim. This study is focused on a comprehensive overview of mechanisms and processes involved in the acquisition of cancer cell plasticity in a manner dependent on the adapter protein Ruk/CIN85 (in rodents, Ruk — regulator of ubiquitous kinase; in human CIN85 — Cbl-interacting protein of 85 kDa, encoded by SH3KBP1 gene).. Methods. Gene expression was evaluated using RT2-PCR and Western blotting, cell proliferation and survival were analyzed using MTT and/or dye exclusion assays, motility was assessed by scratch test and Transwell assay, enzyme activities were measured using spectrophotometric assays. In vivo metastasis were studies using experimental metastasis model. Conclusion. This study discloses various aspects of cancer cells plasticity, such as EMT, stemness, metabolic changes, ECM components, and drug resistance in dependence on adaptor protein Ruk/CIN85 expression level

Cardiac tumors: analysis of surgical treatment

Aim. To analyze the preoperative status, intraoperative tumor characteristics and further clinical manifestations in patients after surgery for a cardiac tumor.Material and methods. The study included 54 patients who were operated on for a heart tumor from 2014 to 2020. We assessed clinical performance, diagnostic investigations before and after (during hospitalization) surgery, tumor size and histological characteristics.Results. Among patients operated on for cardiac tumors, women predominated (74%). Among comorbidities, hypertension (79,3%), chronic kidney disease (48,3%), and obesity (25,9%) were most common. There were following clinical manifestations before surgery: shortness of breath — 47 (81%) patients, palpitations and heart rhythm disturbance — 26 (44,8%), chest pain — 25 (43,1%), chest discomfort — 28 (49,1%), edema — 6 patients (10,3%). The predominant tumor localization was the left atrial fossa ovalis area (50%). According to histological analysis, myxoma prevailed — 38 cases (86,4%). After surgery, atrial fibrillation prevalence decreased from 8 patients before surgery to 6 after surgery (p=0,034), while left atrial size decreased by 0,6 mm (95% confidence interval, 4,39-6,2 mm) (p<0,001).Conclusion. According to presented analysis over a 6-year period, cardiac neoplasms are more common in women (74,1%), while the mean age of patients is 59,7 years. Among comorbidities, hypertension prevails — 79,3%. Histological examination revealed a predominance of myxoma (86,4%). Predominant tumor location was the left atrial fossa ovalis area (50%). Surgical treatment of neoplasms was effective. So, prevalence of atrial fibrillation decreased by 25%, while left atrial size decreased by 0,6 mm. Postoperative complications and in-hospital deaths were not registered

Получение наноразмерных пентаоксидов ниобия и тантала методом сверхкритического флюидного антисольвентного осаждения

Niobium and tantalum methylates with common formula M2(OMe)10 , where M - Nb,Ta, have been synthesized as precursors by electrochemical synthesis for obtaining niobium and tantalum oxides. Ultradispersed and nanosized oxides TT (δ)-Nb2O5 and T (γ)-Ta2O5 were obtained by supercritical fluid technology. The samples are characterized by different methods (chemical analysis, DTA-DTG, XRD, IR-spectroscopy, grain size analysis). It is shown that under the experimental conditions amorphous particles of niobium and tantalum pentoxides are formed, which react to form the crystalline state at temperatures of 600°C and 750°C respectively. Crystallization temperature of T(γ)-Ta2O5 obtained by SAS-technology significantly lower than the crystallization temperature of the same tantalum pentoxide obtained by heterophasic method (900°C). The particle size of the annealed tantalum pentoxide is in the range of nanosized materials, particle size of the annealed niobium pentoxide qualifies them as ultradispersed.Методом сверхкритического флюидного антисольвентного (SAS) осаждения получены ультрадисперсные и наноразмерные оксиды ТТ(δ)-Nb2O5 и Т(γ)-Та2О5 из метилатов ниобия и тантала состава M2(OMe)10 (где M - Nb,Ta) в качестве предшественников

Disruption of the Lipid-Transporting LdMT-LdRos3 Complex in Leishmania donovani Affects Membrane Lipid Asymmetry but Not Host Cell Invasion

Maintenance and regulation of the asymmetric lipid distribution across eukaryotic plasma membranes is governed by the concerted action of specific membrane proteins controlling lipid movement across the bilayer. Here, we show that the miltefosine transporter (LdMT), a member of the P4-ATPase subfamily in Leishmania donovani, and the Cdc50-like protein LdRos3 form a stable complex that plays an essential role in maintaining phospholipid asymmetry in the parasite plasma membrane. Loss of either LdMT or LdRos3 abolishes ATP-dependent transport of NBD-labelled phosphatidylethanolamine (PE) and phosphatidylcholine from the outer to the inner plasma membrane leaflet and results in an increased cell surface exposure of endogenous PE. We also find that promastigotes of L. donovani lack any detectable amount of phosphatidylserine (PS) but retain their infectivity in THP-1-derived macrophages. Likewise, infectivity was unchanged for parasites without LdMT-LdRos3 complexes. We conclude that exposure of PS and PE to the exoplasmic leaflet is not crucial for the infectivity of L. donovani promastigotes

МУЛЬТИСПИРАЛЬНАЯ КОМПЬЮТЕРНАЯ ТОМОГРАФИЯ В ДИАГНОСТИКЕ ПАТОЛОГИИ ДУГИ АОРТЫ И АНОМАЛИЙ БРАХИОЦЕФАЛЬНЫХ АРТЕРИЙ У ДЕТЕЙ ПЕРВОГО ГОДА ЖИЗНИ

Aortic malformations often cause critical states in the neonatal period. MSCT method allows you to get a detailed understanding of the anatomy of vice and identify concomitant bronchopulmonary disease. This paper presents a comparative analysis of 27 patients of the first year of life with the pathology of the aortic arch, which were performed echocardiography and MSCT. After analysis of both research methods in 4 patients revealed a discrepancy echocardiography and MSCT data which led to a change in surgical approach. Just according to SITC 2 patients revealed tracheal stenosis, in one case, isolated, in another due to compression of the vascular ring. MSCT is a highly informative method for diagnosing pathology of the aortic arch and associated bronchopulmonary disease in children in the first year of life.Пороки развития аорты зачастую являются причиной критических состояний в неонатальном периоде. Метод МСКТ позволяет получить детальное представление об анатомии порока и выявить сопутствующую бронхолегочную патологию. В работе представлен сравнительный анализ данных 27 пациентов первого года жизни с патологией дуги аорты, которым была выполнена ЭхоКГ и МСКТ. После анализа обоих методов исследования у 4 пациентов выявлено несоответствие данных ЭхоКГ и МСКТ, что привело к изменению хирургической тактики. Также по данным МСТК, у 2 пациентов выявлен стеноз трахеи, в одном случае - изолированный, в другом - за счет сдавления сосудистым кольцом. МСКТ является высокоинформативным методом диагностики патологии дуги аорты и сопутствующей бронхолегочной патологии у детей первого года жизни

Is the northern high-latitude land-based CO2 sink weakening?

Author Posting. © American Geophysical Union, 2011. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Global Biogeochemical Cycles 25 (2011): GB3018, doi:10.1029/2010GB003813.Studies indicate that, historically, terrestrial ecosystems of the northern high-latitude region may have been responsible for up to 60% of the global net land-based sink for atmospheric CO2. However, these regions have recently experienced remarkable modification of the major driving forces of the carbon cycle, including surface air temperature warming that is significantly greater than the global average and associated increases in the frequency and severity of disturbances. Whether Arctic tundra and boreal forest ecosystems will continue to sequester atmospheric CO2 in the face of these dramatic changes is unknown. Here we show the results of model simulations that estimate a 41 Tg C yr−1 sink in the boreal land regions from 1997 to 2006, which represents a 73% reduction in the strength of the sink estimated for previous decades in the late 20th century. Our results suggest that CO2 uptake by the region in previous decades may not be as strong as previously estimated. The recent decline in sink strength is the combined result of (1) weakening sinks due to warming-induced increases in soil organic matter decomposition and (2) strengthening sources from pyrogenic CO2 emissions as a result of the substantial area of boreal forest burned in wildfires across the region in recent years. Such changes create positive feedbacks to the climate system that accelerate global warming, putting further pressure on emission reductions to achieve atmospheric stabilization targets.This study was supported through grants provided as part of the Arctic System Science Program (NSF OPP‐ 0531047), the North American Carbon Program (NASA NNG05GD25G), and the Bonanza Creek Long‐Term Ecological Program (funded jointly by NSF grant DEB‐0423442 and USDA Forest Service, Pacific Northwest Research Station grant PNW01‐JV11261952‐231)