Design Architecture-Based on Web Server and Application Cluster in Cloud Environment

Cloud has been a computational and storage solution for many data centric organizations. The problem today those organizations are facing from the cloud is in data searching in an efficient manner. A framework is required to distribute the work of searching and fetching from thousands of computers. The data in HDFS is scattered and needs lots of time to retrieve. The major idea is to design a web server in the map phase using the jetty web server which will give a fast and efficient way of searching data in MapReduce paradigm. For real time processing on Hadoop, a searchable mechanism is implemented in HDFS by creating a multilevel index in web server with multi-level index keys. The web server uses to handle traffic throughput. By web clustering technology we can improve the application performance. To keep the work down, the load balancer should automatically be able to distribute load to the newly added nodes in the server

Linear systems analysis program, L224(QR). Volume 1: Engineering and usage

The QR computer program is described as well as its use in classical control systems analysis and synthesis (root locus, time response, and frequency response)

Prediction of the capacitance lineshape in two-channel quantum dots

We propose a set-up to realize two-channel Kondo physics using quantum dots. We discuss how the charge fluctuations on a small dot can be accessed by using a system of two single electron transistors arranged in parallel. We derive a microscopic Hamiltonian description of the set-up that allows us to make connection with the two-channel Anderson model (of extended use in the context of heavy-Fermion systems) and in turn make detailed predictions for the differential capacitance of the dot. We find that its lineshape, which we determined precisely, shows a robust behavior that should be experimentally verifiable.Comment: 4 pages, 3 figure

Probabilistic analysis of bladed turbine disks and the effect of mistuning

Probabilistic assessment of the maximum blade response on a mistuned rotor disk is performed using the computer code NESSUS. The uncertainties in natural frequency, excitation frequency, amplitude of excitation and damping are included to obtain the cumulative distribution function (CDF) of blade responses. Advanced mean value first order analysis is used to compute CDF. The sensitivities of different random variables are identified. Effect of the number of blades on a rotor on mistuning is evaluated. It is shown that the uncertainties associated with the forcing function parameters have significant effect on the response distribution of the bladed rotor

An experimental study of the viscoseal bearing Interim report

Viscoseal bearing experimental analysis of bearing characteristics and sealing performanc

Histomorphological evaluation of colon lesions

Background: Both macroscopic and microscopic appearance helps in identification of the colon lesion which supports in the treatment of the patient in a better way. The authors were aimed at the prevalence of various colon lesions site wise distribution of various neoplastic and non-neoplastic lesions of the patients and to compare the distribution according to their age, sex and site.Methods: A retrospective study was designed to study of various intestinal biopsies sent for histopathological examination at Department of Pathology, N.H.L. Municipal Medical College and V.S. Hospital, Ahmedabad, from January 2015 to December 2016 for period of 2 years. The study was based on the histomorphological evaluation of colon lesions received during the study period.Results: A male preponderance was seen in the incidence of tumors irrespective of tumor type and site of tumor and M:F ratio was 1.64:1. In the large intestine, adenocarcinomas were the commonest malignant tumor. 46 cases (62.61%) were reported. The highest occurrence of appendicitis is in the 2nd and 3rd decade.Conclusions: The study revealed that various types of lesions in large intestine along with the age group and gender affected more. Male patients were majorly affected. Morphological identification helped to diagnose the type of lesion for early diagnosis. This study focuses the role of histopathological identification in early diagnosis of the disease so that the survival rates in such cases will be increased

Optimizing photon indistinguishability in the emission from incoherently-excited semiconductor quantum dots

Most optical quantum devices require deterministic single-photon emitters. Schemes so far demonstrated in the solid state imply an energy relaxation which tends to spoil the coherent nature of the time evolution, and with it the photon indistinguishability. We focus our theoretical investigation on semiconductor quantum dots embedded in microcavities. Simple and general relations are identified between the photon indistinguishability and the collection efficiency. The identification of the key parameters and of their interplay provides clear indications for the device optimization

Development of a three-dimensional time-dependent flow field model

A three-dimensional, time-dependent mathematical model to represent Mobile Bay was developed. Computer programs were developed which numerically solve the appropriate conservation equations for predicting bay and estuary flow fields. The model is useful for analyzing the dispersion of sea water into fresh water and the transport of sediment, and for relating field and physical model data

Effect of Berberine on in vitro metabolism of Sulfonylureas: a herb-drug interactions study

Rationale: Patients with type 2 diabetes may co-ingest herbal and prescription medicine to control their blood sugar levels. Competitive binding of drug and herb may mutually affect their metabolism. This can alter the level of drug and its kinetics in the body, potentially causing toxicities or loss of efficacy. Understanding how metabolism of sulfonylureas like glyburide and gliclazide can be affected by the presence of berberine and vice versa can provide valuable information on the possible risk of toxicities caused by co-ingestion of drugs. Methods: Berberine and sulfonylureas (glyburide and gliclazide) were co-incubated with rat liver microsomes in the presence of NADPH regenerating system. The metabolites of berberine and sulfonylureas were analysed using liquid chromatography with high resolution mass spectrometry in the positive ion mode. The role of individual isozymes in the metabolism of berberine, glyburide and gliclazide was investigated by using specific inhibitors. Results: In vitro metabolism of berberine lead to the formation of demethyleneberberine (B1a) and B1b through demethylenation. Berberrubine (B2a) and its isomer (B2b) was formed through demethylation. The isozymes CYP3A and CYP2D were found to be involved in the metabolism of berberine. In vitro metabolism of glyburide and gliclazide lead to the formation of hydroxylated metabolites. The isozymes CYP3A and CYP2C were found to be involved in the metabolism of glyburide. Gliclazide was metabolised by CYP2C. In vitro co-incubation of glyburide or gliclazide with berberine showed that each drugs metabolism was compromised as both share a common isozymes. A strong negative linear correlation of glyburide or gliclazide metabolites levels and the concentration of berberine confirmed the effect of berberine on the metabolism of sulfonylurea

PROTECTIVE EFFECT OF SYNTHETIC ANTIOXIDANTS AND ETHANOLIC EXTRACT OF BACOPA MONNIERI AGAINST LEAD TOXICITY INDUCED METABOLIC DYSFUNCTIONS IN MICE BRAIN AND LIVER HOMOGENATES: AN IN VITRO APPROACH

Objective: The main objective of the present study was to investigate the ameliorative potential of synthetic antioxidants mixture comprising N-acetyl cysteine, ascorbic acid, tocopheryl acetate, and thiamine as micronutrient combinational therapy and ethanolic extract of Bacopa monnieri as herbal antioxidant therapy approach against lead toxicity-induced metabolic dysfunctions in vitro. Methods: Experimental study involved in vitro exposure of mice brain and liver homogenates to different doses (100 μM, 250 μM, and 500 μM) of lead acetate. The study also involved coadministration of high-dose lead acetate (500 μM) and specific dosage of synthetic antioxidants or ethanolic extract of B. monnieri separately to homogenate cultures. Alterations in metabolic parameters of protein levels and lipid peroxidation were analyzed for evaluating the protective effect of synthetic antioxidants and B. monnieri against lead intoxication. Results: Results revealed dose-dependent statistically significant (p<0.001) reduction in protein levels and elevation in lipid peroxidation in lead acetate exposed mice brain and liver homogenates as compared to their respective control groups. Coadministration of lead acetate and synthetic antioxidants mixture or B. monnieri in the brain and liver homogenates conferred protection and manifested maintenance of studied biochemical parameters nearest to control groups. Ameliorative efficacy of B. monnieri against lead-induced neurotoxicity and hepatotoxicity was found to be more pronounced than that of a mixture of synthetic antioxidants. Conclusion: Synthetic antioxidants mixture (N-acetyl cysteine, ascorbic acid, tocopheryl acetate, and thiamine) and B. monnieri exhibited remarkable therapeutic efficacy against lead toxicity-induced metabolic dysfunctions in mice brain and liver homogenates by virtue of their antioxidant, neuroprotective, and hepatoprotective abilities