854 research outputs found
Natural Suppression of Higgsino-Mediated Proton Decay in Supersymmetric SO(10)
In supersymmetric Grand Unified Theories, proton decay mediated by the
color--triplet higgsino is generally problematic and requires some fine--tuning
of parameters. We present a mechanism which naturally suppresses such dimension
5 operators in the context of SUSY . The mechanism, which implements
natural doublet--triplet splitting using the adjoint higgs, converts these
dimension 5 operators effectively into dimension 6. By explicitly computing the
higgs spectrum and the resulting threshold uncertainties we show that the
successful prediction of is maintained {\it as a prediction}
in this scheme. It is argued that only a weak suppression of the higgsino
mediated proton decay is achievable within SUSY without fine--tuning,
in contrast to a strong suppression in SUSY .Comment: 39 pages (3 Feynman graphs not included), in Plain LaTeX, BA-93-2
Chua mem-components for adaptive RF metamaterials
Chua's mem-components are ideal for creating adaptive metasurfaces for manipulating EM waves given that they hold their state without external biases. In this paper, we propose a generic adaptive reactive element that is in fact a memcapacitor/meminductor. This element makes use of a polymer that demonstrates reversible trans-cis photochemical isomerization, thus making it possible to change the distance between two conductive plates by up to 25%. Furthermore, a design methodology for utilizing these devices is presented
Learning and Recognition of a Non-conscious Sequence of Events in Human Primary Visual Cortex
Published Online: March 03, 2016Human primary visual cortex (V1) has long been
associated with learning simple low-level visual discriminations
[1] and is classically considered outside
of neural systems that support high-level cognitive
behavior in contexts that differ from the original
conditions of learning, such as recognition memory
[2, 3]. Here, we used a novel fMRI-based dichoptic
masking protocol—designed to induce activity in
V1, without modulation from visual awareness—to
test whether human V1 is implicated in human observers
rapidly learning and then later (15–20 min)
recognizing a non-conscious and complex (secondorder)
visuospatial sequence. Learning was associated
with a change in V1 activity, as part of a
temporo-occipital and basal ganglia network, which
is at variance with the cortico-cerebellar network
identified in prior studies of ‘‘implicit’’ sequence
learning that involved motor responses and visible
stimuli (e.g., [4]). Recognition memory was associated
with V1 activity, as part of a temporo-occipital
network involving the hippocampus, under conditions
that were not imputable to mechanisms associated
with conscious retrieval. Notably, the V1 responses
during learning and recognition separately
predicted non-conscious recognition memory, and
functional coupling between V1 and the hippocampus
was enhanced for old retrieval cues. The results
provide a basis for novel hypotheses about the
signals that can drive recognition memory, because
these data (1) identify human V1 with a memory
network that can code complex associative serial
visuospatial information and support later nonconscious
recognition memory-guided behavior (cf.
[5]) and (2) align with mouse models of experiencedependent
V1 plasticity in learning and memory [6].This work was supported by the Wellcome Trust (WT073735MA;
C.R.R. and C.K.; http://www.wellcome.ac.uk/), the Medical Research Council
(UK, 89631; D.S.; http://www.mrc.ac.uk/), the National Institute for Health
Research (NIHR) Oxford Biomedical Research Centre based at Oxford University
Hospitals NHS Trust and University of Oxford (C.R.R., C.A.A., and C.K.;
http://oxfordbrc.nihr.ac.uk/), and the Dementias and Neurodegenerative Diseases
Research Network (C.A.A.; https://www.crn.nihr.ac.uk/dementia)
An Optically-Programmable Absorbing Metasurface
A tunable metasurface absorber is presented in this work using an optically-programmable capacitor as the tuning element. The tuning element does not employ conventional semiconductor technologies to operate but rather a bases its tuning by changing the optomechanical properties of its dielectric, poly disperse red 1 acrylate (PDR1A). Doing so there are no conventional semiconductor devices in the RF signal path. The metasurface operates at a design frequency of 5.5 GHz and it achieves an optically-tuned bandwidth of 150 MHz, from 5.50 GHz to 5.65 GHz
Broad ligament cystic lymphangioma: A case report
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
TAM receptor tyrosine kinase function and the immunopathology of liver disease.
Tyro3, Axl, MERTK (TAM) receptor tyrosine kinases are implicated in the regulation of the innate immune response through clearance of apoptotic cellular debris and control of cytokine signaling cascades. As a result they are pivotal in regulating the inflammatory response to tissue injury. Within the liver, immune regulatory signaling is employed to prevent the overactivation of innate immunity in response to continual antigenic challenge from the gastrointestinal tract. In this review we appraise current understanding of the role of TAM receptor function in the regulation of both innate and adaptive immunity, with a focus on its impact upon hepatic inflammatory pathology
Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction
Diabetes, obesity and Alzheimer’s disease (AD) are associated with vascular complications and impaired nitric oxide (NO) production. Furthermore, increased β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), APP and β-amyloid (Aβ) are linked with vascular disease development and raised BACE1 and Aβ accompany hyperglycemia and hyperlipidemia. However, the causal relationship between obesity and diabetes, raised Aβ and vascular dysfunction is unclear. We report that diet-induced obesity (DIO) in mice raised plasma and vascular Aβ42 that correlated with decreased NO bioavailability, endothelial dysfunction and raised blood pressure. Genetic or pharmacological reduction of BACE1 activity and Aβ42 prevented and reversed, respectively, these outcomes. In contrast, expression of human mutant APP in mice or Aβ42 infusion into control diet-fed mice to mimic obese levels impaired NO production, vascular relaxation and raised blood pressure. In humans, raised plasma Aβ42 correlated with diabetes and endothelial dysfunction. Mechanistically, higher Aβ42 reduced endothelial NO synthase (eNOS), cyclic GMP and protein kinase G (PKG) activity independently of diet whereas endothelin-1 was increased by diet and Aβ42. Lowering Aβ42 reversed the DIO deficit in the eNOS-cGMP-PKG pathway and decreased endothelin-1. Our findings suggest that BACE1 inhibitors may have therapeutic value in the treatment of vascular disease associated with diabetes
Financial crises and the attainment of the SDGs: an adjusted multidimensional poverty approach
This paper analyses the impact of financial crises on the Sustainable Development Goal of eradicating poverty. To do so, we develop an adjusted Multidimensional Poverty Framework (MPF) that includes 15 indicators that span across key poverty aspects related to income, basic needs, health, education and the environment. We then use an econometric model that allows us to examine the impact of financial crises on these indicators in 150 countries over the period 1980–2015. Our analysis produces new estimates on the impact of financial crises on poverty’s multiple social, economic and environmental aspects and equally important captures dynamic linkages between these aspects. Thus, we offer a better understanding of the potential impact of current debt dynamics on Multidimensional Poverty and demonstrate the need to move beyond the boundaries of SDG1, if we are to meet the target of eradicating poverty. Our results indicate that the current financial distress experienced by many low-income countries may reverse the progress that has been made hitherto in reducing poverty. We find that financial crises are associated with an approximately 10% increase of extreme poor in low-income countries. The impact is even stronger in some other poverty aspects. For instance, crises are associated with an average decrease of government spending in education by 17.72% in low-income countries. The dynamic linkages between most of the Multidimensional Poverty indicators, warn of a negative domino effect on a number of SDGs related to poverty, if there is a financial crisis shock. To pre-empt such a domino effect, the specific SDG target 17.4 on attaining long-term debt sustainability through coordinated policies plays a key role and requires urgent attention by the international community
Association of Hippocampal Glutamate Levels With Adverse Outcomes in Individuals at Clinical High Risk for Psychosis
Importance: Preclinical and human data suggest that hippocampal dysfunction plays a critical role in the onset of psychosis. Neural hyperactivity in the hippocampus is thought to drive an increase in subcortical dopamine function through glutamatergic projections to the striatum. Objective: To examine the association between hippocampal glutamate levels in individuals at clinical high risk for psychosis and their subsequent clinical outcomes. Design, Setting, and Participants: This cross-sectional study of 86 individuals at clinical high risk for psychosis and 30 healthy control individuals, with a mean follow-up of 18.5 months, was conducted between November 1, 2011, and November 1, 2017, at early detection services in London and Cambridge, United Kingdom. Main Outcomes and Measures: Concentrations of glutamate and other metabolites were measured in the left hippocampus using 3-T proton magnetic resonance spectroscopy at the first clinical presentation. At follow-up, clinical outcomes were assessed in terms of transition or nontransition to psychosis using the Comprehensive Assessment of the At-Risk Mental State criteria and the level of overall functioning using the Global Assessment of Function scale. Results: Of 116 total participants, 86 were at clinical high risk for psychosis (50 [58%] male; mean [SD] age, 22.4 [3.5] years) and 30 were healthy controls (14 [47%] male; mean [SD] age, 24.7 [3.8] years). At follow-up, 12 clinical high-risk individuals developed a first episode of psychosis whereas 74 clinical high-risk individuals did not; 19 clinical high-risk individuals showed good overall functioning (Global Assessment of Function ≥65), whereas 38 clinical high-risk individuals had a poor functional outcome (Global Assessment of Function <65). Compared with clinical high-risk individuals who did not become psychotic, clinical high-risk individuals who developed psychosis showed higher hippocampal glutamate levels (mean [SD], 8.33 [1.48] vs 9.16 [1.28] glutamate levels; P = .048). The clinical high-risk individuals who developed psychosis also had higher myo-inositol levels (mean [SD], 7.60 [1.23] vs 6.24 [1.36] myo-inositol levels; P = .002) and higher creatine levels (mean [SD], 8.18 [0.74] vs 7.32 [1.09] creatine levels; P = .01) compared with clinical high-risk individuals who did not become psychotic, and higher myo-inositol levels compared with healthy controls (mean [SD], 7.60 [1.23] vs 6.19 [1.51] myo-inositol levels; P = .005). Higher hippocampal glutamate levels in clinical high-risk individuals were also associated with a poor functional outcome (mean [SD], 8.83 [1.43] vs 7.76 [1.40] glutamate levels; P = .02). In the logistic regression analyses, hippocampal glutamate levels were significantly associated with clinical outcome in terms of transition and nontransition to psychosis (β = 0.48; odds ratio = 1.61; 95% CI, 1.00-2.59; P = .05) and overall functioning (β = 0.53; odds ratio = 1.71; 95% CI, 1.10-2.66; P = .02). Conclusions and Relevance: The findings indicate that adverse clinical outcomes in individuals at clinical high risk for psychosis may be associated with an increase in baseline hippocampal glutamate levels, as well as an increase in myo-inositol and creatine levels. This conclusion suggests that these measures could contribute to the stratification of clinical high-risk individuals according to future clinical outcomes
Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction
Background: This study was designed to investigate the association of the 894G>T polymorphism in the eNOS gene with risk of acute myocardial infarction (AMI), extent of coronary artery disease (CAD) on coronary angiography, and in-hospital mortality after AMI.
Methods: We studied 1602 consecutive patients who were enrolled in the GEMIG study. The control group was comprised by 727 individuals, who were randomly selected from the general adult population.
Results: The prevalence of the Asp298 variant of eNOS was not found to be significantly and independently associated with risk of AMI (RR = 1.08, 95%CI = 0.77–1.51, P = 0.663), extent of CAD on angiography (OR = 1.18, 95%CI = 0.63–2.23, P = 0.605) and in-hospital mortality (RR = 1.08, 95%CI = 0.29–4.04, P = 0.908).
Conclusion: In contrast to previous reports, homozygosity for the Asp298 variant of the 894G>T polymorphism in the eNOS gene was not found to be associated with risk of AMI, extent of CAD and in-hospital mortality after AM
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