1,830 research outputs found
Response process and test-retest reliability of the Context Assessment for Community Health tool in Vietnam
Background: The recently developed Context Assessment for Community Health (COACH) tool aims to measure aspects of the local healthcare context perceived to influence knowledge translation in low- and middle-income countries. The tool measures eight dimensions (organizational resources , community engagement, monitoring services for action, sources of knowledge, commitment to work, work culture, leadership, and informal payment) through 49 items. Objective: The study aimed to explore the understanding and stability of the COACH tool among health providers in Vietnam. Designs: To investigate the response process, think-aloud interviews were undertaken with five community health workers, six nurses and midwives, and five physicians. Identified problems were classified according to Conrad and Blair's taxonomy and grouped according to an estimation of the magnitude of the problem's effect on the response data. Further, the stability of the tool was examined using a test–retest survey among 77 respondents. The reliability was analyzed for items (intraclass correlation coefficient (ICC) and percent agreement) and dimensions (ICC and Bland–Altman plots). Results: In general, the think-aloud interviews revealed that the COACH tool was perceived as clear, well organized, and easy to answer. Most items were understood as intended. However, seven prominent problems in the items were identified and the content of three dimensions was perceived to be of a sensitive nature. In the test–retest survey, two-thirds of the items and seven of eight dimensions were found to have an ICC agreement ranging from moderate to substantial (0.5–0.7), demonstrating that the instrument has an acceptable level of stability. Conclusions: This study provides evidence that the Vietnamese translation of the COACH tool is generally perceived to be clear and easy to understand and has acceptable stability. There is, however, a need to rephrase and add generic examples to clarify some items and to further review items with low ICC.Duong M. Duc, Anna Bergström, Leif Eriksson, Katarina Selling, Bui Thi Thu Ha and Lars Walli
Application and validation of the notch master curve in medium and high strength structural steels
This paper applies and validates the Notch master curve in two ferritic steels with medium (steel S460M) and high (steel S690Q) strength. The Notch master curve is an engineering tool that allows the fracture resistance of notched ferritic steels operating within their corresponding ductile-to-brittle transition zone to be estimated. It combines the Master curve and the Theory of critical distances in order to take into account the temperature and the notch effect respectively, assuming that both effects are independent. The results, derived from 168 fracture tests on notched specimens, demonstrate the capability of the Notch master curve for the prediction of the fracture resistance of medium and high strength ferritic steels operating within their ductile-to-brittle transition zone and containing notches
Hydroxy-PCBs, PBDEs, and HBCDDs in serum from an elderly population of Swedish fishermen's wives and associations with bone density
Lack of human exposure data is frequently reported as a critical gap in risk assessments of environmental pollutants, especially regarding "new" pollutants. The objectives of this study were to assess serum levels of the persistent 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153), hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), polybrominated diphenyl ethers (PBDEs), and hexabromocyclododecanes (HBCDDs) in a group of Swedish middle-aged and elderly women expected to be relatively highly exposed, and to evaluate the impact of potential determinants (e.g., fish intake, age) for the inter-individual variation, as well as to investigate the association between these pollutants and bone density. No associations were found between bone mineral density or biochemical markers of bone metabolism and the analyzed environmental pollutants. Relatively high levels of CB-153 (median 260 ng/g fat) and Sigma(3)-OH- PCBs (median 1.7 ng/mL serum), and low concentrations of Sigma 6PBDEs (median 3.6 ng/g fat) were determined. Total level of HBCDDs in serum was quantified by gas chromatography with mass spectrometric detection (median 0.5 ng/g fat). HBCDD diastereomeric and enantiomeric patterns were determined by liquid chromatography with mass spectrometric detection. The dominating stereoisomer was (-)alpha-HBCDD, but 1-3% of gamma-HBCDD was also detected in the serum samples
Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes
BACKGROUND: A diverse class of engineered nanomaterials (ENMs) exhibiting a wide array of physical-chemical properties that are associated with toxicological effects in experimental animals is in commercial use. However, an integrated framework for human health risk assessment (HHRA) of ENMs has yet to be established. Rodent 2-year cancer bioassays, clinical chemistry, and histopathological endpoints are still considered the ‘gold standard’ for detecting substance-induced toxicity in animal models. However, the use of data derived from alternative toxicological tools, such as genome-wide expression profiling and in vitro high-throughput assays, are gaining acceptance by the regulatory community for hazard identification and for understanding the underlying mode-of-action. Here, we conducted a case study to evaluate the application of global gene expression data in deriving pathway-based points of departure (PODs) for multi-walled carbon nanotube (MWCNT)-induced lung fibrosis, a non-cancer endpoint of regulatory importance. METHODS: Gene expression profiles from the lungs of mice exposed to three individual MWCNTs with different physical-chemical properties were used within the framework of an adverse outcome pathway (AOP) for lung fibrosis to identify key biological events linking MWCNT exposure to lung fibrosis. Significantly perturbed pathways were categorized along the key events described in the AOP. Benchmark doses (BMDs) were calculated for each perturbed pathway and were used to derive transcriptional BMDs for each MWCNT. RESULTS: Similar biological pathways were perturbed by the different MWCNT types across the doses and post-exposure time points studied. The pathway BMD values showed a time-dependent trend, with lower BMDs for pathways perturbed at the earlier post-exposure time points (24 h, 3d). The transcriptional BMDs were compared to the apical BMDs derived by the National Institute for Occupational Safety and Health (NIOSH) using alveolar septal thickness and fibrotic lesions endpoints. We found that regardless of the type of MWCNT, the BMD values for pathways associated with fibrosis were 14.0–30.4 μg/mouse, which are comparable to the BMDs derived by NIOSH for MWCNT-induced lung fibrotic lesions (21.0–27.1 μg/mouse). CONCLUSIONS: The results demonstrate that transcriptomic data can be used to as an effective mechanism-based method to derive acceptable levels of exposure to nanomaterials in product development when epidemiological data are unavailable. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12989-016-0125-9) contains supplementary material, which is available to authorized users
Current--Voltage Characteristics of Two--Dimensional Vortex Glass Models
We have performed Monte Carlo simulations to determine current--voltage
characteristics of two different vortex glass models in two dimensions. The
results confirm the conclusions of earlier studies that there is a transition
at . In addition we find that, as , the linear resistance vanishes
exponentially, and the current scale, , where non-linearities appear in
the -- characteristics varies roughly as , quite different from the
predictions of conventional flux creep theory, . The results for
the two models agree quite well with each other, and also agree fairly well
with recent experiments on very thin films of YBCO.Comment: 18 pages with 10 figures available upon request from R. A. Hyman at
[email protected]. The only change in the new version is the
deletion of an unimportant comment.IUCM94-01
Monte Carlo calculation of the current-voltage characteristics of a two dimensional lattice Coulomb gas
We have studied the nonlinear current-voltage characteristic of a two
dimensional lattice Coulomb gas by Monte Carlo simulation. We present three
different determinations of the power-law exponent of the nonlinear
current-voltage characteristic, . The determinations rely on
both equilibrium and non-equilibrium simulations. We find good agreement
between the different determinations, and our results also agree closely with
experimental results for Hg-Xe thin film superconductors and for certain single
crystal thin-film high temperature superconductors.Comment: late
Non-Universality in Random Matrix Ensembles with Soft Level Confinement
Two families of strongly non-Gaussian random matrix ensembles (RME) are
considered. They are statistically equivalent to a one-dimensional plasma of
particles interacting logarithmically and confined by the potential that has
the long-range behavior (),
or . The direct Monte Carlo simulations on
the effective plasma model shows that the spacing distribution function (SDF)
in such RME can deviate from that of the classical Gaussian ensembles. For
power-law potentials, this deviation is seen only near the origin , while for the double-logarithmic potential the SDF shows the cross-over
from the Wigner-Dyson to Poisson behavior in the bulk of the spectrum.Comment: 4 pages, REVTEX, 3 postscript figures appended, ICTP/9/94/ckw.
Flux Pinning and Phase Transitions in Model High-Temperature Superconductors with Columnar Defects
We calculate the degree of flux pinning by defects in model high-temperature
superconductors (HTSC's). The HTSC is modeled as a three-dimensional network of
resistively-shunted Josephson junctions in an external magnetic field,
corresponding to a HTSC in the extreme Type-II limit. Disorder is introduced
either by randomizing the coupling between grains (Model A disorder) or by
removing grains (Model B disorder). Three types of defects are considered:
point disorder, random line disorder, and periodic line disorder; but the
emphasis is on random line disorder. Static and dynamic properties of the
models are determined by Monte Carlo simulations and by solution of the
analogous coupled overdamped Josephson equations in the presence of thermal
noise. Random line defects considerably raise the superconducting transition
temperature T, and increase the apparent critical current density
J, in comparison to the defect-free crystal. They are more effective
in these respects than a comparable volume density of point defects, in
agreement with the experiments of Civale {\it et al}. Periodic line defects
commensurate with the flux lattice are found to raise T even more than
do random line defects. Random line defects are most effective when their
density approximately equals the flux density. Near T, our static and
dynamic results appear consistent with the anisotropic Bose glass scaling
hypotheses of Nelson and Vinokur, but with possibly different critical indices:Comment: 10 pages, LaTeX(REVTeX v3.0, twocolumn), 11 figures (not included
Quantum simulations of the superfluid-insulator transition for two-dimensional, disordered, hard-core bosons
We introduce two novel quantum Monte Carlo methods and employ them to study
the superfluid-insulator transition in a two-dimensional system of hard-core
bosons. One of the methods is appropriate for zero temperature and is based
upon Green's function Monte Carlo; the other is a finite-temperature world-line
cluster algorithm. In each case we find that the dynamical exponent is
consistent with the theoretical prediction of by Fisher and co-workers.Comment: Revtex, 10 pages, 3 figures (postscript files attached at end,
separated by %%%%%% Fig # %%%%%, where # is 1-3). LA-UR-94-270
Spin Bose Glass Phase in Bilayer Quantum Hall Systems at
We develop an effective spin theory to describe magnetic properties of the
Quantum Hall bilayer systems. In the absence of disorder this theory
gives quantitative agreement with the results of microscopic Hartree-Fock
calculations, and for finite disorder it predicts the existence of a novel spin
Bose glass phase. The Bose glass is characterized by the presence of domains of
canted antiferromagnetic phase with zero average antiferromagnetic order and
short range mean antiferromagnetic correlations. It has infinite
antiferromagnetic transverse susceptibility, finite longitudinal spin
susceptibility and specific heat linear in temperature. Transition from the
canted antiferromagnet phase to the spin Bose glass phase is characterized by a
universal value of the longitudinal spin conductance.Comment: 4 pages, 4 eps figure
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