Review of Disability Estimates and Definitions: A study carried out on behalf of the Department for Work and Pensions

This report presents findings of a review of survey estimates of the prevalence of disability in Britain and the definitions of disability used in government social surveys. The study examines the relative merits and methodological robustness of a variety of estimates of the prevalence of disability produced by surveys. The review involved: A technical review of the existing surveys and estimates; A consultation exercise involving key stakeholders and users of disability estimates to explore their views on measurement and definitional issues of disability; An exploration of what might be done to ensure consistency over time of estimates and definitions of disability in Great Britain

Facets of Psychopathy in Relation to Trauma-Exposure and Posttraumatic Stress Symptomology in a Sample of Incarcerated Male Offenders

Purpose: The aim was to investigate the moderating role of psychopathy facets on the relationship between traumatic exposure and posttraumatic stress disorder (PTSD) symptomology. Design/methodology/approach: Participants were male prisoners incarcerated in the U.K. Findings: The analysis revealed differential associations between the two facets of psychopathy, with potentially traumatic events and symptoms of PTSD. Specifically, neither primary psychopathy nor trauma exposure were significantly related to PTSD, while secondary psychopathy was positively and significantly related with PTSD symptoms. Furthermore, the effect of trauma exposure on PTSD was found to depend on the level of secondary psychopathy. More specifically, trauma exposure was strongly and positively associated with PTSD symptoms for low levels of secondary psychopathy and negatively associated with PTSD symptomology for individuals with high levels of secondary psychopathy. Originality/value: The findings clarify linkages among psychopathy facets, trauma, and PTSD, and extend our understanding of the presentation of PTSD in male prisoners

Participation and quality of life outcomes among individuals with earthquake-related physical disability: a systematic review

Objective: A literature review to evaluate quality of life and participation outcomes of individuals with earthquake-related physical injury. Data sources: A systematic review was performed using National Health Service (NHS) Centre for Reviews and Dissemination (CRD) guidelines. MEDLINE, Embase, PsychINFO, CINAHL and AMED electronic databases were searched from 1966 to January 2014. Study selection: Studies that measured quality of life or participation outcomes among individuals who acquired a physical disability as a result of an earthquake injury were included, with no limits on research design. Data extraction: The search yielded 961 potentially relevant articles after removal of duplicates. Of these, only 8 articles met the inclusion criteria. Studies were rated for quality using the Critical Appraisal Skills Programme (CASP) guidelines. Data synthesis: A narrative synthesis was performed due to the heterogeneity of the included studies. Results: Injured earthquake survivors in developing countries experience diminished participation and reduced quality of life. Small sample sizes and lack of uniformity in outcome measurement limit generalizability. No studies from developed countries were identified. Conclusion: To maximize our understanding of quality of life and participation in injured earthquake survivors, future research should consider both the functional consequences of the injury and the environmental impact of the earthquake. The research should be based on representative samples of the injured earthquake survivors and use validated condition-specific outcome measures that are clearly defined within the publications. In addition, research should include all countries that are affected by earthquakes

De-regulation of JNK and JAK/STAT signaling in ESCRT-II mutant tissues cooperatively contributes to neoplastic tumorigenesis

Multiple genes involved in endocytosis and endosomal protein trafficking in Drosophila have been shown to function as neoplastic tumor suppressor genes (nTSGs), including Endosomal Sorting Complex Required for Transport-II (ESCRT-II) components vacuolar protein sorting 22 (vps22), vps25, and vps36. However, most studies of endocytic nTSGs have been done in mosaic tissues containing both mutant and non-mutant populations of cells, and interactions among mutant and non-mutant cells greatly influence the final phenotype. Thus, the true autonomous phenotype of tissues mutant for endocytic nTSGs remains unclear. Here, we show that tissues predominantly mutant for ESCRT-II components display characteristics of neoplastic transformation and then undergo apoptosis. These neoplastic tissues show upregulation of c-Jun N-terminal Kinase (JNK), Notch, and Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) signaling. Significantly, while inhibition of JNK signaling in mutant tissues partially inhibits proliferation, inhibition of JAK/STAT signaling rescues other aspects of the neoplastic phenotype. This is the first rigorous study of tissues predominantly mutant for endocytic nTSGs and provides clear evidence for cooperation among de-regulated signaling pathways leading to tumorigenesis

Observation of anomalous single-magnon scattering in half-metallic ferromagnets by chemical pressure control

Temperature variation of resistivity and specific heat have been measured for prototypical half-metallic ferromagnets, R_0.6Sr_0.4MnO_3, with controlling the one-electron bandwidth W. We have found variation of the temperature scalings in the resistivity from T^2 (R = La, and Nd) to T^3 (R = Sm), and have interpreted the $T^3-law in terms of the anomalous single-magnon scattering (AMS) process in the half-metallic system.Comment: To appear in Phys. Rev. Lett., 3 pages + 4 EPS figure

Spatial and temporal mapping of key lipid species in Brassica napus seeds

The regulation of lipid synthesis in oil seeds is still not fully understood. Oilseed rape is the third most productive vegetable oil crop on the global market. Therefore, increasing our understanding of lipid accumulation in oilseed rape seeds is of great economic, as well as intellectual, importance. Matrix-assisted laser/desorption ionisation - mass spectrometry imaging (MALDI-MSI) is a technique that allows the mapping of metabolites directly onto intact biological tissues, giving a spatial context to metabolism. We have used MADLI-MSI to study the spatial distribution of two major lipid species, triacylglycerols (TAGs) and phosphatidylcholines (PCs). A dramatic, heterogeneous landscape of molecular species was revealed, demonstrating significantly different lipid compositions between the various seed tissues. The embryonic axis was particularly enriched in lipid species containing palmitate, while the seed coat/aleurone layer accumulated vaccenic, linoleic and α-linoleic acids. Furthermore, the lipid composition of the inner and outer cotyledons differed to each other, a remarkable discovery given the supposed identical functionality of these two tissues. TAG and PC molecular species distribution was analysed through a developmental time series covering early seed lipid accumulation to the end of lipid accumulation. The spatial patterning of lipid molecular species did not vary much during seed development, although there were exceptions. Data gathered using MALDI-MSI was verified through gas chromatography analysis of dissected seeds. The distinct lipid distribution profiles observed implies differential regulation of lipid metabolism between the different seed tissues. Further understanding of this differential regulation will enhance efforts to improve oilseed rape productivity and quality

Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape (Brassica napus L.)

With dwindling available agricultural land, concurrent with increased demand for oil, there is much current interest in raising oil crop productivity. We have been addressing this issue by studying the regulation of oil accumulation in oilseed rape (Brassica napus L). As part of this research we have carried out a detailed lipidomic analysis of developing seeds. The molecular species distribution in individual lipid classes revealed quite distinct patterns and showed where metabolic connections were important. As the seeds developed, the molecular species distributions changed, especially in the period of early (20 days after flowering, DAF) to mid phase (27DAF) of oil accumulation. The patterns of molecular species of diacylglycerol, phosphatidylcholine and acyl-CoAs were used to predict the possible relative contributions of diacylglycerol acyltransferase (DGAT) and phospholipid:diacylglycerol acyltransferase to triacylglycerol production. Our calculations suggest that DGAT may hold a more important role in influencing the molecular composition of TAG. Enzyme selectivity had an important influence on the final molecular species patterns. Our data contribute significantly to our understanding of lipid accumulation in the world’s third most important oil crop