Interactions between the endocrine and immune systems in locusts

The prophenoloxidase cascade in the haemolymph of mature adult Locusta migratoria migratorioides (R & F) is activated in response to injection of laminarin, a -1,3 glucan. Co-injection of adipokinetic hormone-I (Lom-AKH-I) and laminarin prolongs the activation of the enzyme in a dose-dependent manner. However, injections of bacterial lipopolysaccharide (LPS) do not activate prophenoloxidase unless AKH is co-injected, when there is a dose-dependent increase in the level of phenoloxidase that persists in the haemolymph for several hours. Even when AKH is co-injected, the highest levels of phenoloxidase activity are always greater after injection of laminarin than after LPS, and these two immunogens must activate the prophenoloxidase cascade by quite distinct pathways. In the present study, interactions between the endocrine and immune systems were examined with respect to activation of prophenoloxidase and the formation of nodules: injection of LPS induces nodule formation in adult locusts. With LPS from Pseudomonas aeruginosa, nodules form exclusively in dense accumulations in the anterior portion of the abdomen on either side of the dorsal blood vessel associated with the dorsal diaphragm. However, with LPS from Escherichia coli, fewer nodules are formed but with a similar distribution, except that occasionally some nodules are aligned additionally on either side of the ventral nerve cord. Co-injection of Lom-AKH-I with LPS from either bacteria stimulates greater numbers of nodules to be formed. This effect of coinjection of AKH on nodule formation is seen at low doses of hormone with only 0.3 or 0.4 pmol of Lom-AKH-1, respectively, increasing the number of nodules by 50%. Injections of octopamine or 5-hydroxytryptamine do not mimic either of the actions of Lom-AKH-I described here. Co-injection of an angiotensin-converting enzyme inhibitor, captopril, reduces nodule formation in response to injections of LPS but has no effect on the activation of phenoloxidase. Co-injection of an inhibitor of eicosanoid synthesis, dexamethasone, with LPS influences nodule formation (with or without AKH) in different ways according to the dose of dexamethasone used, but does not affect activation of prophenoloxidase. Eicosanoid synthesis is important for nodule formation, but not for the activation of the prophenoloxidase cascade in locust haemolymph

Within the Wrought-Iron Fence: the Hidden Heritage of McCormick Theological Seminary, 1864-1975

Few people today realize that the black wrought iron fence that runs along the west side of Halsted Street and west on Belden and Fullerton Avenues to the El tracks once defined the grounds of McCormick Theological Seminary, a Presbyterian Seminary. The first major building site in this area, and the first institution, it was truly the cornerstone of our neighborhood. It continued as an important part of this Lincoln Park neighborhood for more than a hundred years. We see physical evidence of McCormick’s time here in the buildings that remain. But the tightly knit academic, religious and residential community that once existed within the black wrought iron fence is largely forgotten or unknown. Yet its historic presence has much to pass on to those of us who work, study and live on or near the campus. The institution has been gone from our neighborhood for twenty-four years, but its heritage is a foundation for the continuing residential and institutional communities existing side-by-side today. The seminary’s move to Hyde Park in 1975 offered an opportunity for DePaul University to expand its campus. DePaul bought the west end of the McCormick campus in 1976 and the following year purchased the east end. Today DePaul continues the campus heritage of teaching and service. In the center portion of the old campus, the residents of the historic townhouses, owned individually by the members of the Seminary Townhouse Association, continue to raise families in a caring community and carry on other McCormick traditions. Thus the area within the fence continues as a place of families and community, of students and teachers, of learning and fun and of outreach

Exploring Causal Influences

Recent data mining techniques exploit patterns of statistical independence in multivariate data to make conjectures about cause/effect relationships. These relationships can be used to construct causal graphs, which are sometimes represented by weighted node-link diagrams, with nodes representing variables and combinations of weighted links and/or nodes showing the strength of causal relationships. We present an interactive visualization for causal graphs (ICGs), inspired in part by the Influence Explorer. The key principles of this visualization are as follows: Variables are represented with vertical bars attached to nodes in a graph. Direct manipulation of variables is achieved by sliding a variable value up and down, which reveals causality by producing instantaneous change in causally and/or probabilistically linked variables. This direct manipulation technique gives users the impression they are causally influencing the variables linked to the one they are manipulating. In this context, we demonstrate the subtle distinction between seeing and setting of variable values, and in an extended example, show how this visualization can help a user understand the relationships in a large variable set, and with some intuitions about the domain and a few basic concepts, quickly detect bugs in causal models constructed from these data mining techniques

Transient dynamics of a superconducting nonlinear oscillator

We investigate the transient dynamics of a lumped-element oscillator based on a dc superconducting quantum interference device (SQUID). The SQUID is shunted with a capacitor forming a nonlinear oscillator with resonance frequency in the range of several GHz. The resonance frequency is varied by tuning the Josephson inductance of the SQUID with on-chip flux lines. We report measurements of decaying oscillations in the time domain following a brief excitation with a microwave pulse. The nonlinearity of the SQUID oscillator is probed by observing the ringdown response for different excitation amplitudes while the SQUID potential is varied by adjusting the flux bias. Simulations are performed on a model circuit by numerically solving the corresponding Langevin equations incorporating the SQUID potential at the experimental temperature and using parameters obtained from separate measurements characterizing the SQUID oscillator. Simulations are in good agreement with the experimental observations of the ringdowns as a function of applied magnetic flux and pulse amplitude. We observe a crossover between the occurrence of ringdowns close to resonance and adiabatic following at larger detuning from the resonance. We also discuss the occurrence of phase jumps at large amplitude drive. Finally, we briefly outline prospects for a readout scheme for superconducting flux qubits based on the discrimination between ringdown signals for different levels of magnetic flux coupled to the SQUID.Comment: 15 pages, 9 figure

Farm Tractors in Kansas: How to Perfect a Security Interest

This is the published version

Fault-Algebraic Attacks on Inner Rounds of DES

Presentation given at eSmart 2010. -Fault attacks on inner rounds of DES with protected implementation - How to adapt (recent) algebraic attacks DES with too few faulty ciphertexts - A new DFA attack on inner rounds faster than brute force

GrameneMart: the BioMart data portal for the Gramene project

Gramene is a well-established resource for plant comparative genome analysis. Data are generated through automated and curated analyses and made available through web interfaces such as GrameneMart. The Gramene project was an early adopter of the BioMart software, which remains an integral and well-used component of the Gramene website. BioMart accessible data sets include plant gene annotations, plant variation catalogues, genetic markers, physical mapping entities, public DNA/mRNA sequences of various types and curated quantitative trait loci for various species. Database URL: http://www.gramene.org/biomart/martview

Student Tributes to Professor Kent Newmyer

The following are the published remarks of the students and former students of Professor Kent Newmyer who spoke at a celebration honoring his work on Friday, November 8, 2019, at the University of Connecticut School of Law

Spatial Sound Rendering – A Survey

Simulating propagation of sound and audio rendering can improve the sense of realism and the immersion both in complex acoustic environments and dynamic virtual scenes. In studies of sound auralization, the focus has always been on room acoustics modeling, but most of the same methods are also applicable in the construction of virtual environments such as those developed to facilitate computer gaming, cognitive research, and simulated training scenarios. This paper is a review of state-of-the-art techniques that are based on acoustic principles that apply not only to real rooms but also in 3D virtual environments. The paper also highlights the need to expand the field of immersive sound in a web based browsing environment, because, despite the interest and many benefits, few developments seem to have taken place within this context. Moreover, the paper includes a list of the most effective algorithms used for modelling spatial sound propagation and reports their advantages and disadvantages. Finally, the paper emphasizes in the evaluation of these proposed works