ANALYTICAL STANDARDIZATION OF TAMRA YOGA

Rasa Shastra is a specialized branch of Ayurveda which mainly deals with the pharmaceutics of unique and potent preparations. Tamra Yoga is an important Rasa Oushadi mentioned in Rasa Tantra Sara Va Siddha Prayoga Sangraha which contains Tamra Bhasma, Yashtimadhu, Chincha Kshara, Trikatu, Sauvarchala lavana and Hingu. Shodhana, Bhavana, Marana, Amrutikarana, Chincha Kshara nirmana and Churna nirmana are the main pharmaceutical procedures employed in the preparation of Tamra Yoga. To assess the toxicity, safety and to understand the structural and chemical composition, it was tested through various modern analytical parameters like X-ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive X-ray spectroscopy (EDS), Particle size analysis (PSA), Zeta Potential (ZP), UV-Spectroscopy, Fourier transform Infra-Red spectroscopy (FTIR) and Inductively Coupled Plasma – Optical Emission Spectrometry (ICP-OES). XRD of Tamra Yoga shows major peaks of KCl (Potassium Chloride), CuS (Copper Sulphide) and minor peaks of HgS (Cinnabar), NaCl (Sodium Chloride), CaS (Calcium Sulphide) and ZnP4 (Zinc Phosphide), K2Fe2O4 (Potassium Iron Oxide). SEM micrographs showed an agglomeration of crystalline irregular sharped particles; EDS analysis confirmed the significant presence of elements viz. O-27.91%, S-21.83%, Cu-26.87% and Hg- 14.29%, K- 3.46%; Particle size was found to be 337.9nm and its Zeta Potential is -12.1mV. UV- Spectrum of Tamra Yoga showed maximum absorption at 307 nm; FT-IR analysis showed 11 peaks between the wavelengths 3356.21 - 418.34 cm-1 and ICP–OES analysis revealed Potassium as main constituent in 14376.50 ppm

RE-GRADE MODEL FOR LABEL BASED ICON SEARCH

An easy approach must be to attach the whole routing path in each and every packet. The publication within the approach is its message overhead may be large for packets with extended routing pathways. While using the routing route to each packet, many measurement and diagnostic approaches can conduct effective management and protocol optimizations for deployed WSNs made up of a great deal unwatched sensor nodes. own path features a novel an easy-weight hash function for verification within the deduced pathways. To be able to further boost the inference capacity along with execution efficiency, own path features a fast bootstrapping formula to rebuild the very first number of pathways. To really increase the risk for iterative boosting effective and efficient, two problems have to be addressed. The hash function ought to be lightweight and efficient enough since it should be focus on resource-restricted sensor nodes. While using the routing route to each packet, many measurement and diagnostic approaches can conduct effective management and protocol optimizations for deployed WSNs made up of a great deal unwatched sensor nodes. We implement own path and evaluate its performance using traces from large-scale WSN deployments additionally to extensive simulations. Results show own path achieves much greater renovation ratios under different network settings when compared with other condition-of-the-art approaches. When compared with PathZip, own path exploits high path similarity between multiple packets for fast inference, leading to far better scalability

ANALYTICAL STANDARDIZATION OF RAJATA BHASMA

Bhasma Kalpana is a unique part of Ayurvedic Rasa shastra. It is a method of converting metals into metallic Bhasma. Metallic Bhasmas are well known for its quick effectiveness, smaller dose and a long shelf life. However if these Bhasmas are not well prepared and analyzed they can be toxic to human body. Therefore Bhasma Pariksha is given in Ayurveda to confirm the well prepared metallic Bhasma, but in this era we need to analyze the Bhasmas on modern parameters too to make it acceptable globally. So in this study prepared Rajata (Silver) Bhasma is analyzed on various parameters i.e. Ayuvedic parameters i.e., Varitaratwa, Rekhapurnatwa, Slakshantwa and Laghutwa and some modern parameters like, pH, Particle size, Zeta Potential, X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Energy dispersive X-ray spectroscopy, Fourier Transform Infra red Spectroscopy (FTIR), U V – Spectroscopy. Results: pH value is 5.6, UV- spectroscopy showed maximum absorption at 302nm, FT-IR of Rajata bhasma reveals the presence of C-H (alkyl), C-N (Aliphatic amine) groups at different wavelengths, Mean Particle size of Rajata bhasma is 2.7nm, Zeta Potential analysis reveals -19.3 mV, X-RD of Rajata bhasma reaveals the major peaks of HgS (Cinnabar), Ag2S (Silver Sulphide), SEM analysis of Rajata bhasma showed small crystalline particles at 5KX & 10KX magnifications, EDX analysis of Rajata bhasma confirmed the presence of elements viz., Sulphur 20.34%, Oxygen 7.43%, Silver 26.72%, Mercury 45.51% by weight

INSIGHT OF METHANOLIC EXTRACT OF VENTILAGO MADERASPATANA LEAVES ON HEPATOPROTECTIVE ACTIVITY UNDER STREPTOZOTOCIN-INDUCED DIABETIC RATS

Objective: The methanolic leaf extract of Ventilago maderaspatana (MEVML, 200 mg/kg body weight [b.w.]) was investigate to hepatoprotective activity under streptozotocin-induced (45 mg/kg b.w.) diabetic (Di) rats. Methods: In the present study, we determined the blood glucose levels, b.w., insulin, creatinine, and bilirubin levels in normal, Di, Di treated with MEVML and positive control rats. Results: The Di rats shown adverse changes in blood glucose levels, b.w., insulin, creatinine, and bilirubin levels when compared to other group rats. Reverse the adverse changes in the above parameters when treated the Di rats with MEVML Conclusion: The MEVML shown anti-diabetic activity and reverse the adverse changes in the above parameters in liver so that the MEVML supported the traditional claim of the hepatoprotective activity under Di condition

VALUE CHAIN MODEL FOR STEEL MANUFACTURING SECTOR: A CASE STUDY

ABSTRAC

Preference Number Based Taguchi-Utility Method for the Optimization of Multiple Responses

In the present study a multi-objective optimization approach called taguchi-utility method is employed to find the optimal process parameters in turning of AA7075 material. Cutting speed, feed and depth of cut were taken as the process parameters at three different levels. Taguchi’s standard L9 (3^3) orthogonal array has been followed for conducting the experiments. Utility method converts the multi-responses into a single equivalent response in terms of utility index. ANOVA is employed to find the contribution of the process parameters and it is found that depth of cut has the high influence on the overall utility index.

Ocimum sanctum: a review on the pharmacological properties

Herbal medicine, the backbone of traditional medicine in many countries have played an important role in curing the diseases of humans since ancient time. Medicinal plants are great source of bioactive compounds and chemical structures that have potential beneficial effects. The present review compiles information on ethnopharmacologically useful information and pharmacological properties of Ocimum sanctum. Ocimum sanctum (OS) has many medicinal properties like antioxidant, antidiabetic, antiulcer, anticancer, antibacterial, antifungal and other. The phytochemicals compounds of Ocimum, alkaloids, flavonoids, phenolics, essential oils, tannins and saponins play an important role in herbal medicine. Bioactive compounds of Ocimum responsible for its various medicinal properties and their effects at the molecular level need to be investigated in more detail. Furthermore, pharmacological properties of bioactive compounds in Ocimum sanctum are required to confirm the ethnomedicinal claims of Ocimum sanctum for pharmaceutical therapeutic applications

BIOFABRICATION OF SILVER NANOPARTICLES USING AQUEOUS LEAF EXTRACT OF MELIA DUBIA, CHARACTERIZATION AND ANTIFUNGAL ACTIVITY

Objective: To investigate the bio-fabrication of silver nanoparticles (AgNPs) using aqueous leaf extract of Melia dubia (ALM) and test the antifungal activity of AgNPs against pathogenic fungi Aspergillus niger and Candida tropicalis. Methods: 10 ml of aqueous leaf extract of Melia dubia was added to 90 ml of 1 mM silver nitrate and incubated for 8h at room temperature. After incubation, the color change was observed from light yellow to dark brown. The synthesized AgNPs were characterized using UV-Vis spectroscopy, Fourier Transform Infra red spectroscopy (FTIR), Energy Dispersive X-ray Spectroscopy (EDX), Scanning Electron microscopy (SEM), X-ray diffraction analysis (XRD) and Atomic Force Microscopy (AFM). Antifungal activity against Aspergillus niger and Candida tropicalis was carried out by employing the disc diffusion method. Results: UV-Vis spectra confirmed the synthesis of AgNPs by showing characteristic peak between 380-450 nm*. FTIR spectra showed the functional groups possibly involved in the synthesis of AgNPs. EDX confirms the presence of elemental silver at 3 Kev. SEM and AFM showed the synthesized AgNPs were spherical in shape with size ranging between 20-40 nm*. XRD analysis revealed the crystalline nature of AgNPs with face centred cubic (FCC) lattice. AgNPs was found to be very effective against the tested pathogenic fungi A. niger and C. tropicalis and formed the inhibition zones 13.0 and 14.5 mm respectively. Conclusion: It is concluded that the bio-fabrication of AgNPs using aqueous leaf extract of Melia dubia was robust and rapid. The AgNPs were stable and proved to be excellent antifungal agents

Fertility problems in women with polycystic ovary syndrome

Background: PCOS (Poly Cystic Ovary Syndrome) is the most common endocrine disorder in women of reproductive age with high prevalence. It is a leading cause of infertility in women; this draws an attention to this issue. In this study we aimed to know the prevalence, clinical features, fertility problems and management of PCOS.  Methods: In this prospective observational study, women who consulted Obstetrics & Gynaecology department were screened to identify the PCOS problems through clinical histories, PCOS questionnaire and ultrasonography over a period of 6 months at Rajiv Gandhi institute of medical sciences (RIMS) in Kadapa, India. Patients diagnosed with PCOS were assessed for their clinical manifestations, severity, life style and treatment given, and were educated accordingly through patient counselling and leaflets.Results: We observed 6.39 % prevalence out of 970 women. 59 (95.1%) patients were complained irregular menstrual cycles. Infertility was significantly high in PCOS women i.e. 13.35%. 64.4% of PCOS patients had miscarriages.Conclusions: PCOS is a complex condition with high prevalence of fertility problems, needing due attention. There is need to create attentiveness towards this issue. Early diagnosis and proper management with appropriate medicines and lifestyle modifications will improve the condition and prevents complications.