How accurately do adult sons and daughters report and perceive parental deaths from coronary disease?

<b>OBJECTIVES</b>: To describe how adult sons and daughters report and perceive parental deaths from heart disease <b>DESIGN</b>: Two generation family study. <b>SETTING</b>: West of Scotland. <b>SUBJECTS</b>: 1040 sons and 1298 daughters aged 30-59 from 1477 families, whose fathers and mothers were aged 45-64 in 1972-76 and have been followed up for mortality over 20 years. <b>OUTCOME</b> : Perception of a "family weakness" attributable to heart disease. RESULTS : 26% of sons and daughters had a parent who had died of coronary heart disease (CHD). The proportion was higher in older offspring (+18% per 10 year age difference) and in manual compared with non-manual groups (+37%). Eighty nine per cent of parental deaths from CHD were correctly reported by offspring. Only 23% of sons and 34% of daughters with at least one parent who had died of CHD considered that they had a family weakness attributable to heart disease. Perceptions of a family weakness were higher when one or both parents had died of CHD, when parental deaths occurred at a younger age, in daughters compared with sons and in offspring in non-manual compared with manual occupations. <b>CONCLUSIONS</b>: Only a minority of sons and daughters with experience of a parent having died from CHD perceive this in terms of a family weakness attributable to heart disease. Although men in manual occupations are most likely to develop CHD, they are least likely to interpret a parental death from CHD in terms of a family weakness. Health professionals giving advice to patients on their familial risks need to be aware of the difference between clinical definitions and lay perceptions of a family history of heart disease

Some aspects of objective testing in mathematics within the field of further education

The dissertation reviews the role of objective testing in mathematics at institutes of further education in the United Kingdom. The possibilities of usefully expanding this role are also discussed. Within typical further education classes, students exhibit a wider variation in age, maturity, and mathematical ability than is seen in school classes; because of this, testing in colleges is more important, and serves a greater range of purposes, than in schools. The variation in mathematical ability is particularly pronounced in courses where mathematics is a service subject, and any means of rapidly locating areas of weakness early in the course are most valuable. In many colleges, the bulk of the mathematics teaching is of this type, and it may be partly for this reason that further education teachers of mathematics show at least as much interest in objective testing as do those of any other subject. The discussion of the potential role of objective testing with further education students in mathematics is, based, largely on the published findings of prominent researchers in educational assessment methods. The literature, however, covers the wide field of education generally, and evidence based on the writer's own experience at Birmingham Polytechnic is therefore included; a brief account is also given of the practices and attitudes at certain other colleges. Suggestions are offered regarding the use of objective tests at the beginning of, and throughout, each year of a course and proposals are also made for introducing such methods into the formal end-of- session examinations, where at present they appear to be little used. The complete replacement of conventional methods of examining is not suggested, but rather a combination of the two so as to exploit the various strengths of each method

Magnetic Flux Transport at the Solar Surface

After emerging to the solar surface, the Sun's magnetic field displays a complex and intricate evolution. The evolution of the surface field is important for several reasons. One is that the surface field, and its dynamics, sets the boundary condition for the coronal and heliospheric magnetic fields. Another is that the surface evolution gives us insight into the dynamo process. In particular, it plays an essential role in the Babcock-Leighton model of the solar dynamo. Describing this evolution is the aim of the surface flux transport model. The model starts from the emergence of magnetic bipoles. Thereafter, the model is based on the induction equation and the fact that after emergence the magnetic field is observed to evolve as if it were purely radial. The induction equation then describes how the surface flows -- differential rotation, meridional circulation, granular, supergranular flows, and active region inflows -- determine the evolution of the field (now taken to be purely radial). In this paper, we review the modeling of the various processes that determine the evolution of the surface field. We restrict our attention to their role in the surface flux transport model. We also discuss the success of the model and some of the results that have been obtained using this model.Comment: 39 pages, 15 figures, accepted for publication in Space Sci. Re

Methanation of CO over Ni catalyst: A theoretical study

Theoretical methods (generalized valence‐bond calculations) were used to examine the bond energies and geometries of numerous species chemisorbed onto Ni clusters representing Ni surface. These results were used to obtain thermochemical information and to examine various mechanisms for the methanation of CO over Ni: CO+3H^(→)_(2(Ni)) CH_4+H_2O. It is found that chemisorbed formyl radicals (Ni–CHO) lead to a favorably appearing chain reaction that is consistent with current experimental results. In addition, we find a chemisorbed C_2 species that may be the catalytically active C_(ad) formed from dissociation of CO

Building addiction recovery capital through online participation in a recovery community

The study examines how online participation in a recovery community contributes to personal journeys to addiction recovery. We investigate whether recovery capital building - as indicated by increased levels and quality of online social interactions - and markers of positive identity development predict retention in a recovery program designed around fostering community involvement for early stage recovery addicts. We predicted that high levels and quality of online participation on the group's Facebook page and positive identity development predict retention in the program. To map how participants interact online we conducted social network analysis (SNA) based on naturally occurring online data on the Facebook page of a recovery community. We used computerised linguistic analysis to conduct a sentiment analysis of the textual data (capturing social identity markers). We used linear regression analysis to test whether our indicators of recovery capital predict program retention. To illustrate our findings in the context of the recovery community, we also present case studies of two key participants who moved from the periphery to the centre of the social network. By conducting in-depth interviews with these participants we were able to explore personal experiences of social media usage in the context of their recovery journeys for group members who have undergone some of the most significant changes since joining the community. We found that retention in the program was determined by a) the number of comment 'likes' and 'all likes' received on the Facebook page; b) position in the social network (degree of centrality); and c) linguistic content around group identity and achievement. In conclusion, positive online interactions between members of recovery communities support the recovery process through helping participants to develop recovery capital that binds them to groups supportive of positive change

Viral RNA at two stages of reovirus infection is required for the induction of necroptosis

Necroptosis, a regulated form of necrotic cell death, requires the activation of the RIP3 kinase. Here, we identify that infection of host cells with reovirus can result in necroptosis. We find that necroptosis requires sensing of the genomic RNA within incoming virus particles via cytoplasmic RNA sensors to produce type I interferon (IFN). While these events that occur prior to the de novo synthesis of viral RNA are required for the induction of necroptosis, they are not sufficient. The induction of necroptosis also requires late stages of reovirus infection. Specifically, efficient synthesis of double-stranded RNA (dsRNA) within infected cells is required for necroptosis. These data indicate that viral RNA interfaces with host components at two different stages of infection to induce necroptosis. This work provides new molecular details about events in the viral replication cycle that contribute to the induction of necroptosis following infection with an RNA virus. IMPORTANCE An appreciation of how cell death pathways are regulated following viral infection may reveal strategies to limit tissue destruction and prevent the onset of disease. Cell death following virus infection can occur by apoptosis or a regulated form of necrosis known as necroptosis. Apoptotic cells are typically disposed of without activating the immune system. In contrast, necroptotic cells alert the immune system, resulting in inflammation and tissue damage. While apoptosis following virus infection has been extensively investigated, how necroptosis is unleashed following virus infection is understood for only a small group of viruses. Here, using mammalian reovirus, we highlight the molecular mechanism by which infection with a dsRNA virus results in necroptosis

Yellagonga wetlands: a study of the water chemistry and aquatic fauna

Wetlands worldwide are continually threatened by urbanisation and Western Australia is no exception. Since European settlement in 1829, it has been estimated that at least 75% of the wetlands of the Swan Coastal Plain have disappeared (Halse, 1988). The remaining 25% continue to be threatened by eutrophication and pollution, changes in hydrology and water level patterns, clearing of riparian vegetation, aesthetic disruption and weed invasion (CALM, 1980; Davis and Rolls, 1987; Wrigley et al., 1991; Balla and Davis, 1995). These degradation components are interrelated and largely the consequence of the extensive removal of surrounding vegetation..

Large emergency-response exercises: qualitative characteristics - a survey

Exercises, drills, or simulations are widely used, by governments, agencies and commercial organizations, to simulate serious incidents and train staff how to respond to them. International cooperation has led to increasingly large-scale exercises, often involving hundreds or even thousands of participants in many locations. The difference between ‘large’ and ‘small’ exercises is more than one of size: (a) Large exercises are more ‘experiential’ and more likely to undermine any model of reality that single organizations may create; (b) they create a ‘play space’ in which organizations and individuals act out their own needs and identifications, and a ritual with strong social implications; (c) group-analytic psychotherapy suggests that the emotions aroused in a large group may be stronger and more difficult to control. Feelings are an unacknowledged major factor in the success or failure of exercises; (d) successful large exercises help improve the nature of trust between individuals and the organizations they represent, changing it from a situational trust to a personal trust; (e) it is more difficult to learn from large exercises or to apply the lessons identified; (f) however, large exercises can help develop organizations and individuals. Exercises (and simulation in general) need to be approached from a broader multidisciplinary direction if their full potential is to be realized