Glucocorticoids for acute urticaria: study protocol for a double-blind non-inferiority randomised controlled trial

INTRODUCTION: This study protocol describes a trial designed to investigate whether antihistamine alone in patients with acute urticaria does not increase the 7-day Urticaria Activity Score (UAS7) in comparison with an association of antihistamine and glucocorticoids and reduces short-term relapses and chronic-induced urticaria. METHODS AND ANALYSIS: This is a prospective, double-blind, parallel-group, multicentre non-inferiority randomised controlled trial. Two-hundred and forty patients with acute urticaria admitted to emergency department will be randomised in a 1:1 ratio to receive levocetirizine or an association of levocetirizine and prednisone. Randomisation will be stratified by centre. The primary outcome will be the UAS7 at day 7. The secondary outcomes will encompass recurrence of hives and/or itch at day 7; occurrence of spontaneous hives or itch for >6 weeks; patients with angioedema at day 7, and 2, 6, 12 and 24 weeks; new emergency visits for acute urticaria recurrences at days 7 and 14, and 3 months; Dermatology Life Quality Index at days 7 and 14, and 3 and 6 months; and Chronic Urticaria Quality of Life Questionnaire at 6 weeks. ETHICS AND DISSEMINATION: The protocol has been approved by the and will be carried out in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines. A steering committee will oversee the progress of the study. Findings will be disseminated through national and international scientific conferences and publication in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03545464

Place de la nalbuphine (Nubain) dans l'arsenal analgésique moderne

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Traumatismes consécutifs aux accidents de trottinettes

Les trottinettes connaissent un engouement croissant avec la mise en place des trottinettes en libre-service. Toutefois, leur usage n'est pas sans conséquence sur le risque traumatique. Cette étude a pour objectif de décrire la population et les types de lésions des usagers de trottinettes.Matériel et méthode : Les données proviennent du registre des victimes d'accident de la circulation du département du Rhône qui inclut toute personne blessée ou tuée à la suite d'un accident de la route survenu dans le département du Rhône et pris en charge dans une structure sanitaire privée ou publique. La période étudiée concerne l'année 2019. Les informations recueillies concernent les caractéristiques individuelles, accidentelles, lésionnelles de la victime ainsi que son devenir. Les lésions sont codées grâce à l'Abbreviated Injury Scale (AIS). Les blessés graves sont définis par des lésions d'AIS 3 et plus.Résultats : Au total, 1 186 accidents de trottinette ayant entraîné 1 197 usagers blessés ont été recensés, dont 90 % dans l'hypercentre urbain, avec un nombre d'accidents de trottinettes multiplié par 7,3 entre 2018 et 2019. Cette augmentation a été observée depuis l'été 2018 avec l'introduction de sociétés proposant des locations de trottinettes. L'accident s'est produit seul, sans antagoniste dans 77 % des cas (n = 920). Le port du casque était rare (n = 72 ; 6 %). La grande majorité (n = 869 ; 73 %) des blessés était âgée de 10 à 34 ans, et les 20 à 24 ans (n = 301) représentaient le quart de l'effectif. Pour 11 accidents, il y avait deux blessés usagers de la même trottinette. Il y avait en moyenne deux lésions par victime. Les atteintes graves (MAIS 3 et plus) représentaient 3,8 % des lésions, et il n'y avait pas de différence statistiquement significative pour les lésions graves entre trottinette électrique et trottinette à propulsion humaine (p = 0,20). Comparées aux lésions des cyclistes dont les caractéristiques des accidents sont proches, les blessures de l'extrémité céphalique prédominent chez les usagers de trottinette (37 vs 27 % ; p < 0,001).Conclusion : Devant l'utilisation grandissante des trottinettes parmi les modes de déplacement, une évaluation scientifique des victimes de traumatismes est nécessaire pour proposer des recommandations visant à limiter les traumatismes graves. Ce travail constitue une première étape vers la surveillance épidémiologique tant en termes de recommandations que d'évolution

Analyse du lien entre AVC et niveau de vie dans le Rhône

International audienc

Clinical characteristics and outcome of elderly patients admitted in emergency department with an oxygen mismatch and type 2 myocardial infarction or myocardial injury

International audienceBACKGROUND: Aging is a risk factor for type 2 myocardial infarction or myocardial injury, but few data are available on the elderly. We aimed to determine the factors associated with these pathologies and mortality in the elderly population and its age classes. METHODS: A retrospective cohort of all patients with oxygen mismatch (anemia, hypoxia, tachycardia, hypo/hypertension) for whom a troponin drawn was performed at admission in 2 emergency departments. Medical records were reviewed and classified as having type 2 myocardial infarction, acute or chronic myocardial injury, or no myocardial injury. RESULTS: Of the 824 patients who presented with oxygen mismatch, 675 (81.9%) were older than 65 years. Age over 85 years was a risk factor for acute non-ischemic myocardial injury (odds ratio, 95% confidence interval 2.23, 1.34-3.73). Non-ischemic myocardial injury was associated with hypoxemia, tachycardia, and acute renal failure in those older than 85 years, but only with acute infection in the 75-84-year-old group. Type 2 myocardial infarction was associated only with acute renal failure in the oldest group and, in the 75-84-year-old group, with acute heart failure and shock. Patients older than 85 years with acute myocardial injury, with or without infarction, had a higher in-hospital mortality, but subsequently, mortality depends more on the comorbidities than on age. CONCLUSION: Factors associated with type 2 myocardial infarction and acute non-ischemic myocardial injury in elderly admitted with oxygen mismatch vary notably between age classes. They are associated with in-hospital mortality but not with subsequent mortality when other cormorbities are taken into account

Outcome of patients admitted with oxygen mismatch and myocardial injury or infarction in emergency departments

International audienceAIMS: To describe the outcomes and associated factors in a population of patients admitted to emergency departments with at least one condition of oxygen supply/demand imbalance, regardless of the troponin result or restrictive criteria for type 2 myocardial infarction. METHODS: We constituted a retrospective cohort of 824 patients. Medical records of patients having undergone a troponin assay were reviewed for selection and classification, and data including in-hospital stay and readmissions were collected. The reported outcomes are in-hospital mortality, 3-year mortality, and major adverse cardiovascular events. RESULTS: Patients with myocardial infarction or injury, either chronic or acute, were older, with more history of hypertension and chronic heart or renal failure but not for other cardiovascular risk factors and medical history. Acute myocardial injury and type 2 myocardial infarction were significantly associated with in-hospital mortality [odds ratio (OR) 3.71 95% confidence interval (CI) 1.90-7.33 and OR 3.15 95% CI 1.59-6.28, respectively]. However, the long-term mortality does not differ in comparison with patients presenting chronic myocardial injury or nonelevated troponin, ranging from 26.9 to 34.3%. Patients with chronic myocardial injury and type 2 myocardial infarction had more long-term major cardiovascular events (39.3 and 38.8%), but only for acute heart failure, and none was associated with this outcome after adjustment. CONCLUSION: Among patients admitted to emergency departments with an oxygen supply/demand imbalance, acute myocardial injury and type 2 myocardial infarction are strongly associated with in-hospital mortality. However, they are not associated with higher long-term mortality or major cardiovascular events after discharge, which tend to occur in elderly people with comorbidities

Measurement of the potential geographic accessibility from call to definitive care for patient with acute stroke

Abstract Background The World Health Organization refers to stroke, the second most frequent cause of death in the world, in terms of pandemic. Present treatments are only effective within precise time windows. Only 10% of thrombolysis patients are eligible. Late assessment of the patient resulting from admission and lack of knowledge of the symptoms is the main explanation of lack of eligibility. Methods The aim is the measurement of the time of access to treatment facilities for stroke victims, using ambulances (firemen ambulances or EMS ambulances) and private car. The method proposed analyses the potential geographic accessibility of stroke care infrastructure in different scenarios. The study allows better considering of the issues inherent to an area: difficult weather conditions, traffic congestion and failure to respect the distance limits of emergency transport. Results Depending on the scenario, access times vary considerably within the same commune. For example, between the first and the second scenario for cities in the north of Rhône county, there is a 10 min difference to the nearest Primary Stroke Center (PSC). For the first scenario, 90% of the population is 20 min away of the PSC and 96% for the second scenario. Likewise, depending on the modal vector (fire brigade or emergency medical service), overall accessibility from the emergency call to admission to a Comprehensive Stroke Center (CSC) can vary by as much as 15 min. Conclusions The setting up of the various scenarios and modal comparison based on the calculation of overall accessibility makes this a new method for calculating potential access to care facilities. It is important to take into account the specific pathological features and the availability of care facilities for modelling. This method is innovative and recommendable for measuring accessibility in the field of health care. This study makes possible to highlight the patients’ extension of care delays. Thus, this can impact the improvement of patient care and rethink the healthcare organization. Stroke is addressed here but it is applicable to other pathologies