494 research outputs found
Quantum Theory of Noncommutative Fields
Generalizing the noncommutative harmonic oscillator construction, we propose
a new extension of quantum field theory based on the concept of "noncommutative
fields". Our description permits to break the usual particle-antiparticle
degeneracy at the dispersion relation level and introduces naturally an
ultraviolet and an infrared cutoff. Phenomenological bounds for these new
energy scales are given.Comment: LaTeX file, JHEP3.cls, subequations.sty; 12 pages, no figures. Final
version published in JHEP with some references adde
Noncommutative Electromagnetism As A Large N Gauge Theory
We map noncommutative (NC) U(1) gauge theory on R^d_C X R^{2n}_{NC} to U(N ->
\infty) Yang-Mills theory on R^d_C, where R^d_C is a d-dimensional commutative
spacetime while R^{2n}_{NC} is a 2n-dimensional NC space. The resulting U(N)
Yang-Mills theory on R^d_C is equivalent to that obtained by the dimensional
reduction of (d+2n)-dimensional U(N) Yang-Mills theory onto R^d_C. We show that
the gauge-Higgs system (A_\mu,\Phi^a) in the U(N -> \infty) Yang-Mills theory
on R^d_C leads to an emergent geometry in the (d+2n)-dimensional spacetime
whose metric was determined by Ward a long time ago. In particular, the
10-dimensional gravity for d=4 and n=3 corresponds to the emergent geometry
arising from the 4-dimensional N=4 vector multiplet in the AdS/CFT duality. We
further elucidate the emergent gravity by showing that the gauge-Higgs system
(A_\mu,\Phi^a) in half-BPS configurations describes self-dual Einstein gravity.Comment: 25 pages; More clarifications, to appear in Eur. Phys. J.
Step-Wise Computational Synthesis of Fullerene C60 derivatives. 1.Fluorinated Fullerenes C60F2k
The reactions of fullerene C60 with atomic fluorine have been studied by
unrestricted broken spin-symmetry Hartree-Fock (UBS HF) approach implemented in
semiempirical codes based on AM1 technique. The calculations were focused on a
sequential addition of fluorine atom to the fullerene cage following indication
of the cage atom highest chemical susceptibility that is calculated at each
step. The effectively-non-paired-electron concept of the fullerene atoms
chemical susceptibility lays the foundation of the suggested computational
synthesis. The obtained results are analyzed from energetic, symmetry, and the
composition abundance viewpoints. A good fitting of the data to experimental
findings proves a creative role of the suggested synthesis methodology.Comment: 33 pages, 11 figures, 2 tables, 2 chart
Deformations of quantum field theories on spacetimes with Killing vector fields
The recent construction and analysis of deformations of quantum field
theories by warped convolutions is extended to a class of curved spacetimes.
These spacetimes carry a family of wedge-like regions which share the essential
causal properties of the Poincare transforms of the Rindler wedge in Minkowski
space. In the setting of deformed quantum field theories, they play the role of
typical localization regions of quantum fields and observables. As a concrete
example of such a procedure, the deformation of the free Dirac field is
studied.Comment: 35 pages, 3 figure
Lectures on Nongeometric Flux Compactifications
These notes present a pedagogical review of nongeometric flux
compactifications. We begin by reviewing well-known geometric flux
compactifications in Type II string theory, and argue that one must include
nongeometric "fluxes" in order to have a superpotential which is invariant
under T-duality. Additionally, we discuss some elementary aspects of the
worldsheet description of nongeometric backgrounds. This review is based on
lectures given at the 2007 RTN Winter School at CERN.Comment: 31 pages, JHEP
Quantum Gravity from Noncommutative Spacetime
We review a novel and authentic way to quantize gravity. This novel approach
is based on the fact that Einstein gravity can be formulated in terms of a
symplectic geometry rather than a Riemannian geometry in the context of
emergent gravity. An essential step for emergent gravity is to realize the
equivalence principle, the most important property in the theory of gravity
(general relativity), from U(1) gauge theory on a symplectic or Poisson
manifold. Through the realization of the equivalence principle, which is an
intrinsic property in symplectic geometry known as the Darboux theorem or the
Moser lemma, one can understand how diffeomorphism symmetry arises from
noncommutative U(1) gauge theory; thus, gravity can emerge from the
noncommutative electromagnetism, which is also an interacting theory. As a
consequence, a background-independent quantum gravity in which the prior
existence of any spacetime structure is not a priori assumed but is defined by
using the fundamental ingredients in quantum gravity theory can be formulated.
This scheme for quantum gravity can be used to resolve many notorious problems
in theoretical physics, such as the cosmological constant problem, to
understand the nature of dark energy, and to explain why gravity is so weak
compared to other forces. In particular, it leads to a remarkable picture of
what matter is. A matter field, such as leptons and quarks, simply arises as a
stable localized geometry, which is a topological object in the defining
algebra (noncommutative -algebra) of quantum gravity.Comment: 97 pages, to be published in J. Korean Phys. So
MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression
Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically encountered in toxic shock syndrome (TSS). Given the rapidity with which TSS develops, designing timely and truly targeted therapies for this syndrome requires identification of key mediators of the cytokine storm's initial wave. Equally important, early host responses to SAgs can be accompanied or followed by a state of immunosuppression, which in turn jeopardizes the host's ability to combat and clear infections. Unlike in mouse models, the mechanisms underlying SAg-associated immunosuppression in humans are ill-defined. In this work, we have identified a population of innate-like T cells, called mucosa-associated invariant T (MAIT) cells, as the most powerful source of pro-inflammatory cytokines after exposure to SAgs. We have utilized primary human peripheral blood and hepatic mononuclear cells, mouse MAIT hybridoma lines, HLA-DR4-transgenic mice, MAIThighHLA-DR4+ bone marrow chimeras, and humanized NOD-scid IL-2Rγnull mice to demonstrate for the first time that: i) mouse and human MAIT cells are hyperresponsive to SAgs, typified by staphylococcal enterotoxin B (SEB); ii) the human MAIT cell response to SEB is rapid and far greater in magnitude than that launched by unfractionated conventional T, invariant natural killer T (iNKT) or γδ T cells, and is characterized by production of interferon (IFN)-γ, tumor necrosis factor (TNF)-α and interleukin (IL)-2, but not IL-17A; iii) high-affinity MHC class II interaction with SAgs, but not MHC-related protein 1 (MR1) participation, is required for MAIT cell activation; iv) MAIT cell responses to SEB can occur in a T cell receptor (TCR) Vβ-specific manner but are largely contributed by IL-12 and IL-18; v) as MAIT cells are primed by SAgs, they also begin to develop a molecular signature consistent with exhaustion and failure to participate in antimicrobial defense. Accordingly, they upregulate lymphocyte-activation gene 3 (LAG-3), T cell immunoglobulin and mucin-3 (TIM-3), and/or programmed cell death-1 (PD-1), and acquire an anergic phenotype that interferes with their cognate function against Klebsiella pneumoniae and Escherichia coli; vi) MAIT cell hyperactivation and anergy co-utilize a signaling pathway that is governed by p38 and MEK1/2. Collectively, our findings demonstrate a pathogenic, rather than protective, role for MAIT cells during infection. Furthermore, we propose a novel mechanism of SAg-associated immunosuppression in humans. MAIT cells may therefore provide an attractive therapeutic target for the management of both early and late phases of severe SAg-mediated illnesses
Gated Diffusion-controlled Reactions
The binding and active sites of proteins are often dynamically occluded by motion of the nearby polypeptide. A variety of theoretical and computational methods have been developed to predict rates of ligand binding and reactivity in such cases. Two general approaches exist, "protein centric" approaches that explicitly treat only the protein target, and more detailed dynamical simulation approaches in which target and ligand are both treated explicitly. This mini-review describes recent work in this area and some of the biological implications
The antioxidant enzyme peroxiredoxin-2 is depleted in lymphocytes seven days after ultra-endurance exercise
Purpose: Peroxiredoxin-2 (PRDX-2) is an antioxidant and chaperone-like protein critical for cell function. This study examined whether the levels of lymphocyte PRDX-2 are altered over one month following ultra-endurance exercise. Methods: Nine middle-aged men undertook a single-stage, multi-day 233 km (145 mile) ultra-endurance running race. Blood was collected immediately before (PRE), upon completion/retirement (POST), and following the race at DAY 1, DAY 7 and DAY 28. Lymphocyte lysates were examined for PRDX-2 by reducing SDS-PAGE and western blotting. In a sub-group of men who completed the race (n = 4) PRDX-2 oligomeric state (indicative of redox status) was investigated. Results: Ultra-endurance exercise caused significant changes in lymphocyte PRDX-2 (F (4,32) 3.409, p=0.020, ?(2) =0.299): seven-days after the race, PRDX-2 levels in lymphocytes had fallen to 30% of pre-race values (p=0.013) and returned to near-normal levels at DAY 28. Non-reducing gels demonstrated that dimeric PRDX-2 (intracellular reduced PRDX-2 monomers) was increased in 3 of 4 race completers immediately post-race, indicative of an "antioxidant response". Moreover, monomeric PRDX-2 was also increased immediately post-race in 2 of 4 race-completing subjects, indicative of oxidative damage, which was not detectable by DAY 7. Conclusions: Lymphocyte PRDX-2 was decreased below normal levels 7 days after ultra-endurance exercise. Excessive accumulation of reactive oxygen species induced by ultra-endurance exercise may underlie depletion of lymphocyte PRDX-2 by triggering its turnover after oxidation. Low levels of lymphocyte PRDX-2 could influence cell function and might, in part, explain reports of dysregulated immunity following ultra-endurance exercise
A mathematical and computational review of Hartree-Fock SCF methods in Quantum Chemistry
We present here a review of the fundamental topics of Hartree-Fock theory in
Quantum Chemistry. From the molecular Hamiltonian, using and discussing the
Born-Oppenheimer approximation, we arrive to the Hartree and Hartree-Fock
equations for the electronic problem. Special emphasis is placed in the most
relevant mathematical aspects of the theoretical derivation of the final
equations, as well as in the results regarding the existence and uniqueness of
their solutions. All Hartree-Fock versions with different spin restrictions are
systematically extracted from the general case, thus providing a unifying
framework. Then, the discretization of the one-electron orbitals space is
reviewed and the Roothaan-Hall formalism introduced. This leads to a exposition
of the basic underlying concepts related to the construction and selection of
Gaussian basis sets, focusing in algorithmic efficiency issues. Finally, we
close the review with a section in which the most relevant modern developments
(specially those related to the design of linear-scaling methods) are commented
and linked to the issues discussed. The whole work is intentionally
introductory and rather self-contained, so that it may be useful for non
experts that aim to use quantum chemical methods in interdisciplinary
applications. Moreover, much material that is found scattered in the literature
has been put together here to facilitate comprehension and to serve as a handy
reference.Comment: 64 pages, 3 figures, tMPH2e.cls style file, doublesp, mathbbol and
subeqn package
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