Three Square Food Bank

Three Square provides food assistance to residents that suffer from food insecurity.https://digitalscholarship.unlv.edu/educ_sys_202/1064/thumbnail.jp

Reward modulates spatial neglect

Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and 85 reproduction in any medium, provided the original author and source are credited. The article was made available through the Brunel University Open Access Publishing Fund.BACKGROUND: Reward has been shown to affect attention in healthy individuals, but there have been no studies addressing whether reward influences attentional impairments in patients with focal brain damage. METHODS: Using two novel variants of a widely-used clinical cancellation task, we assessed whether reward modulated impaired attention in 10 individuals with left neglect secondary to right hemisphere stroke. RESULTS: Reward exposure significantly reduced neglect, as measured by total targets found, left-sided targets found and centre of cancellation, across the patient group. Lesion analysis showed that lack of response to reward was associated with damage to the ipsilateral striatum. CONCLUSIONS: This is the first experimental evidence that reward can modulate attentional impairments following brain damage. These results have significant implications for the development of behavioural and pharmacological therapies for patients with attentional disorders.PM is supported by a HEFCE Clinical Senior Lectureship Award and this research was funded by grants from the UK Academy of Medical Sciences/Wellcome Trust and the NIHR Biomedical Research Centre at Imperial College London. DS is supported by a grant from the UK Medical Research Council (89631). CR is supported by a Brunel Research Initiative Award (BRIEF) and a scientific bursary from the Bial foundation, Portugal

Mission: Impossible (Escape from the Lyman Limit)

We investigate the intrinsic opacity of high-redshift galaxies to outgoing ionising photons using high-quality photometry of a sample of 27 spectroscopically-identified galaxies of redshift 1.9<z<3.5 in the Hubble Deep Field. Our measurement is based on maximum-likelihood fitting of model galaxy spectral energy distributions-including the effects of intrinsic Lyman-limit absorption and random realizations of intervening Lyman-series and Lyman-limit absorption-to photometry of galaxies from space- and ground-based broad-band images. Our method provides several important advantages over the methods used by previous groups, including most importantly that two-dimensional sky subtraction of faint-galaxy images is more robust than one-dimensional sky subtraction of faint-galaxy spectra. We find at the 3sigma statistical confidence level that on average no more than 4% of the ionising photons escape galaxies of redshift 1.9<z<3.5. This result is consistent with observations of low- and moderate-redshift galaxies but is in direct contradiction to a recent result based on medium-resolution spectroscopy of high-redshift (z~3) galaxies. Dividing our sample in subsamples according to luminosity, intrinsic ultraviolet colour, and redshift, we find no evidence for selection effects that could explain such discrepancy. Even when all systematic effects are included, the data could not realistically accomodate any escape fraction value larger than ~15%.Comment: Accepted for publication in Monthly Notices of the Royal Astronomical Society. 8 pages, 4 b/w figures, MNRAS styl

The gaseous extent of galaxies and the origin of Lyman alpha absorption systems. IV: Lyman alpha absorbers arising in a galaxy group

We present new GHRS observations of Lyman alpha absorption lines associated with a group of galaxies towards the QSO 1545+2101. We have identified eight distinct Lyman alpha absorption features in the spectrum of QSO 1545+2101 at a mean redshift of z=0.2648 with a velocity dispersion of 163 km/s. A group of galaxies is detected in the vicinity of this QSO at a mean redshift of z=0.2645 and velocity dispersion 239 km/s. The identification of discrete absorption systems indicates that they arise in clouds of neutral hydrogen rather than in a diffuse intragroup medium. Our analysis suggests that the Lyman alpha absorption lines are associated with individual galaxies in the group, although a one-to-one relationship between absorbers and galaxies is difficult to establish in such a dense environment.Comment: 16 pages, 3 figures. Accepted for publication in Ap

Differential miRNA expression profiling reveals miR-205-3p to be a potential radiosensitizer for low- dose ionizing radiation in DLD-1 cells

Indexación: Scopus.Departamento de Oncología Básico-Clínica, Facultad de Medicina, Universidad de Chile, Santiago, Chile 2Comisión Chilena de Energía Nuclear, Santiago, Chile 3Center for Research and Applications in Plasma Physics and Pulsed Power, P4, Chile 4Departamento de Ciencias Físicas, Universidad Andres Bello, Santiago, Chile 5Centro de Investigación y Tratamiento del Cáncer, Facultad de Medicina, Universidad de Chile, Santiago, Chile 6Current Address: Center of Excellence in Precision Medicine, Pfizer, Chile. on IR responsive modeling. This work was supported by Anillo grant ACT1115 and ACT172101, PIA Program, CONICYT; the Chilean doctoral fellowship 21130246Enhanced radiosensitivity at low doses of ionizing radiation (IR) (0.2 to 0.6 Gy) has been reported in several cell lines. This phenomenon, known as low doses hyperradiosensitivity (LDHRS), appears as an opportunity to decrease toxicity of radiotherapy and to enhance the effects of chemotherapy. However, the effect of low single doses IR on cell death is subtle and the mechanism underlying LDHRS has not been clearly explained, limiting the utility of LDHRS for clinical applications. To understand the mechanisms responsible for cell death induced by low-dose IR, LDHRS was evaluated in DLD-1 human colorectal cancer cells and the expression of 80 microRNAs (miRNAs) was assessed by qPCR array. Our results show that DLD-1 cells display an early DNA damage response and apoptotic cell death when exposed to 0.6 Gy. miRNA expression profiling identified 3 over-expressed (miR-205-3p, miR-1 and miR-133b) and 2 downregulated miRNAs (miR-122-5p, and miR-134-5p) upon exposure to 0.6 Gy. This miRNA profile differed from the one in cells exposed to high-dose IR (12 Gy), supporting a distinct low-dose radiation-induced cell death mechanism. Expression of a mimetic miR- 205-3p, the most overexpressed miRNA in cells exposed to 0.6 Gy, induced apoptotic cell death and, more importantly, increased LDHRS in DLD-1 cells. Thus, we propose miR-205-3p as a potential radiosensitizer to low-dose IR. © Andaur et al.http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=25405&path[]=7956