Tumor necrosis factor inhibitors in psoriatic arthritis.

INTRODUCTION: Psoriatic arthritis (PsA) is a chronic inflammatory disease that can result in significant disability. With the emergence of tumor necrosis factor inhibitors (TNFi), therapeutic outcomes in PsA have improved substantially. The clinical efficacy and the inhibition of radiographic progression demonstrated by TNFi have transformed the management of PsA. However, there is still an unmet need for a subset of patients who do not respond adequately to TNFi. Areas covered: This review provides an overview of the pharmacokinetics of TNFi, the efficacy of TNFi in PsA, and the role of immunogenicity of TNFi in the treatment of PsA. In addition, we address the use of TNFi in the setting of other medications utilized in the treatment of PsA and the potential future role of biosimilars. Expert commentary: Monoclonal antibodies exhibit complex and widely variable pharmacokinetics. The study of factors that can affect the pharmacokinetics, such as immunogenicity, is valuable to further define and understand the use of TNFi in PsA, especially in the subset of patients who do not respond adequately to these agents or lose effectiveness over time

Drug Interaction Study Of Apixaban With Cyclosporine Or Tacrolimus: Results From A Phase 1, Randomized, Open-Label, Crossover Study In Healthy Volunteers

BACKGROUND Solid organ transplant recipients commonly require anticoagulation. Apixaban (APX) is principally metabolized by CYP3A4, undergoes direct intestinal excretion, and is a substrate to P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) transporters. We examined the potential drug interaction between cyclosporine (CsA) and tacrolimus (Tac) [combined inhibitors of CYP3A4, P-gp and, BCRP] with APX.https://jdc.jefferson.edu/petposters/1005/thumbnail.jp

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Heat Transfer in an Upper Convected Maxwell Fluid with Fluid Particle Suspension

An analysis is carried out to study the magnetohydrodynamic (MHD) flow and heat transfer characteristics of an electrically conducting dusty non-Newtonian fluid, namely, the upper convected Maxwell (UCM) fluid over a stretching sheet. The stretching velocity and the temperature at the surface are assumed to vary linearly with the distance from the origin. Using a similarity transformation, the governing nonlinear partial differential equations of the model problem are transformed into coupled non-linear ordinary differential equations and the equations are solved numerically by a second order finite difference implicit method known as the Keller-box method. Comparisons with the available results in the literature are presented as a special case. The effects of the physical parameters on the fluid velocity, the velocity of the dust particle, the density of the dust particle, the fluid temperature, the dust-phase temperature, the skin friction, and the wall-temperature gradient are presented through tables and graphs. It is observed that, Maxwell fluid reduces the wall-shear stress. Also, the fluid particle interaction reduces the fluid temperature in the boundary layer. Furthermore, the results obtained for the flow and heat transfer characteristics reveal many interesting behaviors that warrant further study on the non-Newtonian fluid flow phenomena, especially the dusty UCM fluid flow phenomena

Comparison of Clustering Techniques: PAM and SSM-PAM: Experiments and Test cases

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