Concert recording 2018-10-09

[Track 1]. Concerto. I. Andante II. Adagio III. Presto / Alessandro Marcello -- [Track 2]. Sonata for trumpet & piano. I. Allegro vivace II. Largo, allegro III. Presto con fuoco / Morten Lauridsen -- [Track 3]. Paths - In memoriam Witold Lutoslawski / Toru Takemitsu -- [Track 4]. Cententnial horizon. I. Aspen grove Interlude-Alpenglow II. Roaring Gunnison / Kevin McKee

Kadar Autoantibodi dan Manifestasi Klinis pada Pasien Nefritis Lupus Silent dan Nefritis Lupus Overt

Autoantibodies level and clinical manifestation differences between patients with silent nephritis lupus and overt nephritis lupusBackground: One of the serious clinical manifestations of SLE is the occurrence of lupus nephritis (LN). The pathogenesis of LN is still unclear. Glomerular inflammation has been associated with high levels of autoantibodies. The purpose of this study was to assess the difference of ANA, anti ds-DNA, anti-Sm antibodies and the clinical manifestations between silent lupus nephritis (SLN) and overt lupus nephritis (OLN).Subject and Methods: Subjects were forty SLE patients (diagnosed according to ARA criteria of 1997). Autoantibodies ANA was assayed with IFA, anti-dsDNA and anti-Sm levels were assayed with ELISA. The diagnosis of LN was established using clinical signs, urinary sediments pattern and kidney biopsy, and then patients classified as a silent lupus nephritis (SLN) or overt lupus nephritis (ONL). Classification of NL histopathologic pattern was established according to WHO criteria. Differences in clinical manifestations, presence of ANA, anti-dsDNA and anti-Sm levels in the SLN and OLN and NL classes were analyzed by Chi squaretest and T test. Statistical significance determined when p<0.05.Results: OLN patients showed a edema, hypertension, anemia and autoantibodies more higher than in SLN patients. The mean level of anti-dsDNA was significantly higher in patients with OLN than in SLN (285.75±41.85 vs 179.01±61.81, p<0.000). Renal biopsy on 20 OLN patients showed: 6 patients with NL grade I/II, 9 patients with NL class III/IV and 5 patients with NL class V. Moreover on 11 SLN patients there were 7 patients with NL class I/II, 3 patients with NL class III/IV and 1 patient with NL class V. The NL classIII/IV NL patients showed anti-dsDNA level higher than the class V NL (p<0.05).Conclusion: OLN patients had clinical manifestations more severe than SLN patients. NL patients with class III/IV showed the presence of anti-dsDNA more frequently and with higher levels than the class V NL. Diagnosing NL based solely on clinical signs and laboratory often is inappropriate

Monogamy of Quantum Discord by Multipartite Correlations

We introduce a monogamy inequality for quantum correlations, which implies that the sum of pairwise quantum correlations is upper limited by the amount of multipartite quantum correlations as measured by the global quantum discord. This monogamy bound holds either for pure or mixed quantum states provided that bipartite quantum discord does not increase under discard of subsystems. We illustrate the monogamy behavior for multipartite pure states with Schmidt decomposition as well as for W-GHZ mixed states. As a by-product, we apply the monogamy bound to investigate residual multipartite correlations.Comment: 5 pages, 2 figures. v2: published versio

Quantum Correlations in Multipartite Quantum Systems

We review some concepts and properties of quantum correlations, in particular multipartite measures, geometric measures and monogamy relations. We also discuss the relation between classical and total correlationsComment: to be published as a chapter of the book "Lectures on general quantum correlations and their applications" edited by F. Fanchini, D. Soares-Pinto, and G. Adesso (Springer, 2017

Transnational agricultural land acquisitions threaten biodiversity in the Global South

Agricultural large-scale land acquisitions have been linked with enhanced deforestation and land use change. Yet the extent to which transnational agricultural large-scale land acquisitions (TALSLAs) contribute to—or merely correlate with—deforestation, and the expected biodiversity impacts of the intended land use changes across ecosystems, remains unclear. We examine 178 georeferenced TALSLA locations in 40 countries to address this gap. While forest cover within TALSLAs decreased by 17% between 2000 and 2018 and became more fragmented, the spatio-temporal patterns of deforestation varied substantially across regions. While deforestation rates within initially forested TALSLAs were 1.5 (Asia) to 2 times (Africa) higher than immediately surrounding areas, we detected no such difference in Europe and Latin America. Our findings suggest that, whereas TALSLAs may have accelerated forest loss in Asia, a different mechanism might emerge in Africa where TALSLAs target areas already experiencing elevated deforestation. Regarding biodiversity (here focused on vertebrate species), we find that nearly all (91%) studied deals will likely experience substantial losses in relative species richness (−14.1% on average within each deal)—with mixed outcomes for relative abundance—due to the intended land use transitions. We also find that 39% of TALSLAs fall at least partially within biodiversity hotspots, placing these areas at heightened risk of biodiversity loss. Taken together, these findings suggest distinct regional differences in the nature of the association between TALSLAs and forest loss and provide new evidence of TALSLAs as an emerging threat to biodiversity in the Globa

Quantum discord evolution of three-qubit states under noisy channels

We investigated the dissipative dynamics of quantum discord for correlated qubits under Markovian environments. The basic idea in the present scheme is that quantum discord is more general, and possibly more robust and fundamental, than entanglement. We provide three initially correlated qubits in pure Greenberger-Horne-Zeilinger (GHZ) or W state and analyse the time evolution of the quantum discord under various dissipative channels such as: Pauli channels $\sigma_{x}$, $\sigma_{y}$, and $\sigma_{z}$, as well as depolarising channels. Surprisingly, we find that under the action of Pauli channel $\sigma_{x}$, the quantum discord of GHZ state is not affected by decoherence. For the remaining dissipative channels, the W state is more robust than the GHZ state against decoherence. Moreover, we compare the dynamics of entanglement with that of the quantum discord under the conditions in which disentanglement occurs and show that quantum discord is more robust than entanglement except for phase flip coupling of the three qubits system to the environment.Comment: 17 pages, 4 figures, accepted for publication in EPJ

Uji Diagnostik Quantitative Sensory Testing (Qst) Untuk Mengidentifikasi Polineuropati Pada Pasien Diabetes Melitus Tipe 2

Latar Belakang: Neuropati diabetes merupakan komplikasi diabetes yang serius dan paling sering terjadi. Polineuropati DM merupakan bentuk yang paling banyak ditemukan pada neuropati diabetes (sekitar 75%). Pemeriksaan ENMG cukup mahal, tidak banyak tersedia, dan memerlukan tenaga ahli khusus. Penelitian ini mengevaluasi nilai diagnostik Quantitative Sensory Testing Vibration Perception Threshold (VPT), Warm Perception Threshold (WPT), dan Cold Perception Threshold (CPT) untuk mengidentifikasi polineuropati pada pasien DM tipe 2. Metode: Penelitian cross sectional ini dilaksanakan di poliklinik endokrin RSUD dr. Saiful Anwar (RSSA) Malang sejak Maret hingga Oktober 2018. Total 113 subyek memenuhi kriteria inklusi dan tidak didapatkan kriteria ekslusi diperiksa pada penelitian ini. Seluruh subyek penelitian dilakukan pemeriksaan VPT, WPT, dan CPT yang dibandingkan dengan kriteria polineuropati DM menurut American Academy of Neurology (AAN). Hasil: Prevalensi polineuropati DM menurut kriteria AAN adalah 80%. Nilai sensitivitas VPT sebesar 83% dan spesifisitas 39%. Sensitivitas WPT sebesar 83% dengan spesifisitas 52%. Sensitivitas CPT sebesar 88% dan spesifisitas 52%. Sensitivitas kombinasi VPT dan CPT sebesar 93% dan spesifisitas 26%. Nilai sensitivitas kombinasi VPT dan WPT sebesar 92% dan spesifisitas 26%. Sensitivitas kombinasi WPT dan CPT sebesar 89% dan spesifisitas 52%. Nilai sensitivitas kombinasi VPT, WPT dan CPT sebesar 94% dan spesifisitas 26%. Kesimpulan: Tes kuantitas sensoris VPT, WPT, dan CPT memiliki sensitivitas serta akurasi yang baik dalam mendeteksi polineuropati DM. Idealnya dilakukan evaluasi pada ketiga modalitas (VPT, WPT, dan CPT) dalam mendeteksi polineuropati DM. Pada kondisi yang tidak memungkinkan dilakukan ketiga modalitas, pemeriksaan CPT atau kombinasi WPT dan CPT dapat dipertimbangkan sebagai pemeriksaan yang dipili

Studies on the Restriction of Murine Leukemia Viruses by Mouse APOBEC3

APOBEC3 proteins function to restrict the replication of retroviruses. One mechanism of this restriction is deamination of cytidines to uridines in (−) strand DNA, resulting in hypermutation of guanosines to adenosines in viral (+) strands. However, Moloney murine leukemia virus (MoMLV) is partially resistant to restriction by mouse APOBEC3 (mA3) and virtually completely resistant to mA3-induced hypermutation. In contrast, the sequences of MLV genomes that are in mouse DNA suggest that they were susceptible to mA3-induced deamination when they infected the mouse germline. We tested the possibility that sensitivity to mA3 restriction and to deamination resides in the viral gag gene. We generated a chimeric MLV in which the gag gene was from an endogenous MLV in the mouse germline, while the remainder of the viral genome was from MoMLV. This chimera was fully infectious but its response to mA3 was indistinguishable from that of MoMLV. Thus, the Gag protein does not seem to control the sensitivity of MLVs to mA3. We also found that MLVs inactivated by mA3 do not synthesize viral DNA upon infection; thus mA3 restriction of MLV occurs before or at reverse transcription. In contrast, HIV-1 restricted by mA3 and MLVs restricted by human APOBEC3G do synthesize DNA; these DNAs exhibit APOBEC3-induced hypermutation

Different Modes of Retrovirus Restriction by Human APOBEC3A and APOBEC3G In Vivo

The apolipoprotein B editing complex 3 (A3) cytidine deaminases are among the most highly evolutionarily selected retroviral restriction factors, both in terms of gene copy number and sequence diversity. Primate genomes encode seven A3 genes, and while A3F and 3G are widely recognized as important in the restriction of HIV, the role of the other genes, particularly A3A, is not as clear. Indeed, since human cells can express multiple A3 genes, and because of the lack of an experimentally tractable model, it is difficult to dissect the individual contribution of each gene to virus restriction in vivo. To overcome this problem, we generated human A3A and A3G transgenic mice on a mouse A3 knockout background. Using these mice, we demonstrate that both A3A and A3G restrict infection by murine retroviruses but by different mechanisms: A3G was packaged into virions and caused extensive deamination of the retrovirus genomes while A3A was not packaged and instead restricted infection when expressed in target cells. Additionally, we show that a murine leukemia virus engineered to express HIV Vif overcame the A3G-mediated restriction, thereby creating a novel model for studying the interaction between these proteins. We have thus developed an in vivo system for understanding how human A3 proteins use different modes of restriction, as well as a means for testing therapies that disrupt HIV Vif-A3G interactions.United States. Public Health Service (Grant R01-AI-085015)United States. Public Health Service (Grant T32-CA115299 )United States. Public Health Service (Grant F32-AI100512