549 research outputs found
Specific volumes of the Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 alloy in the liquid, glass, and crystalline states
The specific volumes of the Zr41.2Ti13.8CU12.5Ni10.0Be2.25 alloy as a function of temperature, T, are determined by employing an image digitizing technique and numerical calculation methods applied to the electrostatically levitated spherical alloy. The linear fitting of the volumes of the alloy in the liquid, V-l, glass, V-g, and crystalline V-c, states in the temperature ranges shown in parentheses are V-l(T) = 0.1583 + 8.877 x 10(-6)T(cm^(3)/g) (700-1300 K); V-g(T) = 0.1603 + 5.528 x 10^(-6)T (400-550 K); V-c(T) = 0.1583 + 6.211 x 10(-6)T(400-850 K). The average volume thermal expansion coefficients within the temperature ranges are determined to be 5.32, 3.39, and 3.83 x 10^(-5) (1/K) for the liquid, glass, and crystalline states, respectively
G protein-coupled receptor kinase 2 regulates mitochondrial bioenergetics and impairs myostatin-mediated autophagy in muscle cells
G protein-coupled receptor kinase 2 (GRK2) is an important protein involved in ÎČ-adrenergic receptor desensitization. In addition, studies have shown GRK2 can modulate different metabolic processes in the cell. For instance, GRK2 has been recently shown to promote mitochondrial biogenesis and increase ATP production. However, the role of GRK2 in skeletal muscle and the signaling mechanisms that regulate GRK2 remain poorly understood. Myostatin is a well-known myokine that has been shown to impair mitochondria function. Here, we have assessed the role of myostatin in regulating GRK2 and the subsequent downstream effect of myostatin regulation of GRK2 on mitochondrial respiration in skeletal muscle. Myostatin treatment promoted the loss of GRK2 protein in myoblasts and myotubes in a time- and dose-dependent manner, which we suggest was through enhanced ubiquitin-mediated protein loss, as treatment with proteasome inhibitors partially rescued myostatin-mediated loss of GRK2 protein. To evaluate the effects of GRK2 on mitochondrial respiration, we generated stable myoblast lines that overexpress GRK2. Stable overexpression of GRK2 resulted in increased mitochondrial content and enhanced mitochondrial/oxidative respiration. Interestingly, although overexpression of GRK2 was unable to prevent myostatin-mediated impairment of mitochondrial respiratory function, elevated levels of GRK2 blocked the increased autophagic flux observed following treatment with myostatin. Overall, our data suggest a novel role for GRK2 in regulating mitochondria mass and mitochondrial respiration in skeletal muscle
Microscopic description of Gamow-Teller transitions in middle pf--shell nuclei by a realistic shell model calculation
GT transitions in nuclei are studied in terms of a large-scale
realistic shell-model calculation, by using Towner's microscopic parameters.
values to low-lying final states are reproduced with a reasonable
accuracy. Several gross properties with respect to the GT transitions are
investigated with this set of the wavefunctions and the operator. While the
calculated total GT strengths show no apparent disagreement with the
measured ones, the calculated total GT strengths are somewhat larger than
those obtained from charge-exchange experiments. Concerning the Ikeda sum-rule,
the proportionality of to persists to an excellent
approximation, with a quenching factor of 0.68. For the relative GT
strengths among possible isospin components, the lowest isospin component
gathers greater fraction than expected by the squared CG coefficients of the
isospin coupling. It turns out that these relative strengths are insensitive to
the size of model space. Systematics of the summed values are
discussed for each isospin component.Comment: IOP-LaTeX 23 pages, to appear in J. Phys. G., 5 Postscript figures
available upon reques
Extending acoustic inâline pipe rheometry and friction factor modelling to lowâReynoldsânumber, nonâNewtonian slurries
The rheology of nonâNewtonian slurries are measured in a recirculating pipe loop using an acoustic velocimetryâpressure drop technique at very low flow rates and variable solids loadings. The technique avoids (a) settling at low solids concentration, a shortcoming of bench rheometry, by using a vertical test section, and (b) physical sampling, providing greater safety. Speed of sound in the suspensions is also modelled. Inâline and offâline data are used to assess the suitability of several nonâNewtonian models to describe observed flow behaviour. Measured and predicted values of the friction factor are compared, with the Madlener et al. (2009) HerschelâBulkley Extended model found to be superior. The dependence of yield stress and viscosity on solids loading and particle size is investigated, showing complexities from aggregation on the particle size distribution require more interpretation than the choice of rheological or frictionâfactor model
Composite Polarons in Ferromagnetic Narrow-band Metallic Manganese Oxides
A new mechanism is proposed to explain the colossal magnetoresistance and
related phenomena. Moving electrons accompanied by Jahn-Teller phonon and
spin-wave clouds may form composite polarons in ferromagnetic narrow-band
manganites. The ground-state and finite-temperature properties of such
composite polarons are studied in the present paper. By using a variational
method, it is shown that the energy of the system at zero temperature decreases
with the formation of composite polaron; the energy spectrum and effective mass
of the composite polaron at finite temperature is found to be strongly
renormalized by the temperature and the magnetic field. It is suggested that
the composite polaron contribute significantly to the transport and the
thermodynamic properties in ferromagnetic narrow-band metallic manganese
oxides.Comment: Latex, no figur
First decay study of the very neutron-rich isotope Br-93
The decay of the mass-separated, very neutron-rich isotope Br-93 has been
studied by gamma-spectroscopy. A level scheme of its daughter Kr-93 has been
constructed. Level energies, gamma-ray branching ratios and multipolarities
suggest spins and parities which are in accord with a smooth systematics of the
N=57 isotones for Z less-equal 40, suggesting the N=56 shell closure still to
be effective in Kr isotopes. So far, there is no indication of a progressive
onset of deformation in neutron-rich Kr isotopes.Comment: 17 pages, 3 figures, Phys. Rev. C, in prin
Quadrupole and Hexadecapole Correlations in Rotating Nuclei Studied within the Single-j Shell Model
The influence of quadrupole and hexadecapole residual interactions on
rotational bands is investigated in a single-j shell model. An exact
shell-model diagonalization of quadrupole-plus-hexadecapole interaction can
sometimes produce a staggering of energy levels in the yrast bands.Comment: 15 pages, 9 Postscript figures, REVTEX, to be published in PR
A comparison of the efficacy of dimethyl sulfoxide (dmso) and synovial fluid in the prevention of peritoneal adhesions: experimental rabbit model
Application of the extended P+QQ force model to fp shell nuclei
To study collective motion, the extended pairing plus force model
proposed recently is applied to =46, 48 and 50 nuclei in the shell
region.
Exact shell model calculations in the truncated model space
prove the usefulness of the interaction.
The simple model with the pairing plus quadrupole pairing plus force and
-independent isoscalar proton-neutron force reproduces unexpectedly well
observed binding energies, energy levels of collective (yrast) states and
reduced transition probabilities in Ti, V, V,
Cr, Cr and Mn.
The correspondence between theory and experiment is almost comparable to that
attained by the full shell model calculations with realistic effective
interactions. Some predictions are made for energy levels and variations of
in the yrast bands, in these nuclei. Characteristics of the interaction
are investigated by comparing with the realistic effective interactions.Comment: 34 pages including 14 figure
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