99 research outputs found
Taloyhtiön pihasaneeraus : Esimerkkikohteena As Oy Kananlaulu
Työn taustana käytettiin lähiöiden suurimman aikakauden, 1960- ja 1970-lukujen kerrostalojen
ajankohtaista peruskorjaustarvetta. Peruskorjaustarve koskee niin kiinteistön piha-aluetta kuin kiinteistön
muitakin osia. Pihojen suurin korjaustarve perustuu kuluneiden kalusteiden, varusteiden,
kasvillisuuden ja muiden osien huonokuntoisuuteen. Lisäksi muuttuneet turvallisuusvaatimukset
sekä esteettömyyden haasteet tuovat lisätarvetta pihojen saneerauksille.
Työni tavoitteena oli lisätä viihtyisyyttä ja parantaa Asunto Oy Kananlaulun piha-aluetta sen saneerauksella.
Saneerauksessa huomioidaan metsälähiön tyypilliset pihasuunnittelun erityispiirteet.
Piha-alueen analyysin avulla arvioitiin sen nykytilaa paikan päällä kohteessa. Samalla tutustuttiin
myös suunnitelma- ja urakka-asiakirjoihin.
Työn pohjana tutkittiin kerrostalorakentamisen ja niiden piha-aluerakentamisen kehitystä Suomessa.
Tietopohjaksi haettiin tietoa myös kerrostalopihojen kunnostuksesta ja kunnostusprosessista.
Tuloksena oli kirjallinen selostus piharakentamisen vaiheista. Työni toimeksiantajana oli VRJ
Pohjois-Suomi Oy.
Työn tulokset ovat hyödynnettävissä kerrostalopihojen peruskorjaushankkeissa. Asunto Oy Kananlaulun
piha-analyysi ja pihasaneeraus voidaan liittää osaksi Kaukovainion kehittämistä. Työn tulokset
antavat myös minulle itselleni mahdollisuuden kehittää omaa osaamistani viherrakentamisen
työnjohdossa.As a background for the work was used the topical need of renovation in the block of flats in the
suburbs built in the 1960- and 1970´s. The renovation need applies both to the yard and the other
parts of the property. The biggest need of renovation is based on the poor condition of the worn
out equipment, vegetation and other parts of the yard. Furthermore the changed requirements of
safety and accessibility increase the renovation need.
The goal on my work was to add the comfort and attractiveness of the yard of Asunto Oy Kananlaulu.
During the renovation the typical characteristics of a wooden suburb were taken into account.
The present situation of the yard was estimated on site. At the same time I familiarized myself the
documents of planning and subcontracting.
For the background of the work the development of the building of the block of flats and their yards
was investigated. Also the renovation of yards and the process of renovation was studied. The
result of the work is a written report of the stages of the yard construction. The principal of the work
was VRJ Pohjois-Suomi Oy.
The results of the work can be utilized in high-rise yards’ renovation projects. The analyses and
renovation of the yard can be linked to the development of Kaukovainio area. The results of the
work gave me the possibility to develop my own skills on supervision of work at green construction
Protective Intestinal Effects of Pituitary Adenylate Cyclase Activating Polypeptide
Pituitary adenylate cyclase activating polypeptide (PACAP) is an
endogenous neuropeptide widely distributed throughout the body, including the
gastrointestinal tract. Several effects have been described in human and animal
intestines. Among others, PACAP infl uences secretion of intestinal glands, blood
fl ow, and smooth muscle contraction. PACAP is a well-known cytoprotective peptide
with strong anti-apoptotic, anti-infl ammatory, and antioxidant effects. The
present review gives an overview of the intestinal protective actions of this neuropeptide.
Exogenous PACAP treatment was protective in a rat model of small bowel
autotransplantation. Radioimmunoassay (RIA) analysis of the intestinal tissue showed that endogenous PACAP levels gradually decreased with longer-lasting
ischemic periods, prevented by PACAP addition. PACAP counteracted deleterious
effects of ischemia on oxidative stress markers and cytokines. Another series of
experiments investigated the role of endogenous PACAP in intestines in PACAP
knockout (KO) mice. Warm ischemia–reperfusion injury and cold preservation models
showed that the lack of PACAP caused a higher vulnerability against ischemic
periods. Changes were more severe in PACAP KO mice at all examined time points.
This fi nding was supported by increased levels of oxidative stress markers and
decreased expression of antioxidant molecules. PACAP was proven to be protective
not only in ischemic but also in infl ammatory bowel diseases. A recent study showed
that PACAP treatment prolonged survival of Toxoplasma gondii infected mice suffering
from acute ileitis and was able to reduce the ileal expression of proinfl ammatory
cytokines. We completed the present review with recent clinical results obtained
in patients suffering from infl ammatory bowel diseases. It was found that PACAP
levels were altered depending on the activity, type of the disease, and antibiotic
therapy, suggesting its probable role in infl ammatory events of the intestine
Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME): Study protocol for a randomised controlled trial
Background: Abdominal aortic aneurysm (AAA) is a slowly progressive destructive process of the main abdominal artery. Experimental studies indicate that fibrates exert beneficial effects on AAAs by mechanisms involving both serum lipid modification and favourable changes to the AAA wall. Methods/design: Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME) is a multicentre, randomised, double-blind, placebo-controlled clinical trial to assess the effect of orally administered therapy with fenofibrate on key pathological markers of AAA in patients undergoing open AAA repair. A total of 42 participants scheduled for an elective open AAA repair will be randomly assigned to either 145 mg of fenofibrate per day or identical placebo for a minimum period of 2 weeks prior to surgery. Primary outcome measures will be macrophage number and osteopontin (OPN) concentration within the AAA wall as well as serum concentrations of OPN. Secondary outcome measures will include levels of matrix metalloproteinases and proinflammatory cytokines within the AAA wall, periaortic fat and intramural thrombus and circulating concentrations of AAA biomarkers. Discussion: At present, there is no recognised medical therapy to limit AAA progression. The FAME trial aims to assess the ability of fenofibrate to alter tissue markers of AAA pathology. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12612001226897. Registered on 20 November 2012. © 2017 The Author(s)
Evidence for a Fourteenth mtDNA-Encoded Protein in the Female-Transmitted mtDNA of Marine Mussels (Bivalvia: Mytilidae)
BACKGROUND: A novel feature for animal mitochondrial genomes has been recently established: i.e., the presence of additional, lineage-specific, mtDNA-encoded proteins with functional significance. This feature has been observed in freshwater mussels with doubly uniparental inheritance of mtDNA (DUI). The latter unique system of mtDNA transmission, which also exists in some marine mussels and marine clams, is characterized by one mt genome inherited from the female parent (F mtDNA) and one mt genome inherited from the male parent (M mtDNA). In freshwater mussels, the novel mtDNA-encoded proteins have been shown to be mt genome-specific (i.e., one novel protein for F genomes and one novel protein for M genomes). It has been hypothesized that these novel, F- and M-specific, mtDNA-encoded proteins (and/or other F- and/or M-specific mtDNA sequences) could be responsible for the different modes of mtDNA transmission in bivalves but this remains to be demonstrated. METHODOLOGY/PRINCIPAL FINDINGS: We investigated all complete (or nearly complete) female- and male-transmitted marine mussel mtDNAs previously sequenced for the presence of ORFs that could have functional importance in these bivalves. Our results confirm the presence of a novel F genome-specific mt ORF, of significant length (>100aa) and located in the control region, that most likely has functional significance in marine mussels. The identification of this ORF in five Mytilus species suggests that it has been maintained in the mytilid lineage (subfamily Mytilinae) for ∼13 million years. Furthermore, this ORF likely has a homologue in the F mt genome of Musculista senhousia, a DUI-containing mytilid species in the subfamily Crenellinae. We present evidence supporting the functionality of this F-specific ORF at the transcriptional, amino acid and nucleotide levels. CONCLUSIONS/SIGNIFICANCE: Our results offer support for the hypothesis that "novel F genome-specific mitochondrial genes" are involved in key biological functions in bivalve species with DUI
Evaluation of a novel oxidation ditch system for biological nitrogen and phosphorus removal from domestic sewage
A novel oxidation ditch system using anaerobic tanks and innovative dual dissolved oxygen (DO) control technology is proposed for biological nitrogen and phosphorus removal from domestic sewage. A continuous bench-scale experiment running for more than 300 days was performed to evaluate the system. Monitoring and controlling the airflow and recirculation flow rate independently using DO values at two points along the ditch permitted maintenance of aerobic and anoxic zone ratios of around 0.30 and 0.50, respectively. The ability to optimize aerobic and anoxic zone ratios using the dual DO control technology meant that a total nitrogen removal efficiency of 83.2–92.9% could be maintained. This remarkable nitrogen removal performance minimized the nitrate recycle to anaerobic tanks inhibiting the phosphorus release. Hence, the total phosphorus removal efficiency was also improved and ranged within 72.6–88.0%. These results demonstrated that stabilization of the aerobic and anoxic zone ratio by dual DO control technology not only resulted in a marked improvement of nitrogen removal, but it also enhanced phosphorus removal.</jats:p
Development of gas-fired small-scale glass melting furnace
Translated from Japanese (30. Ann. Tech. Rep. Tokyo Gas R D Inst. p. 143-153)SIGLEAvailable from British Library Document Supply Centre- DSC:9022.0481(BG-Trans-M--15030)T / BLDSC - British Library Document Supply CentreGBUnited Kingdo
A high-efficient intermittant combusion system
Translated from Japanese (Ann. Rep. Tokyo Gas Research Inst. 1986 p. 179-192)Available from British Library Document Supply Centre- DSC:9022.0481(BG-MRS-Trans--15066)T / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo
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