657 research outputs found
Stellar and Molecular Radii of a Mira Star: First Observations with the Keck Interferometer Grism
Using a new grism at the Keck Interferometer, we obtained spectrally
dispersed (R ~ 230) interferometric measurements of the Mira star R Vir. These
data show that the measured radius of the emission varies substantially from
2.0-2.4 microns. Simple models can reproduce these wavelength-dependent
variations using extended molecular layers, which absorb stellar radiation and
re-emit it at longer wavelengths. Because we observe spectral regions with and
without substantial molecular opacity, we determine the stellar photospheric
radius, uncontaminated by molecular emission. We infer that most of the
molecular opacity arises at approximately twice the radius of the stellar
photosphere.Comment: 12 pages, including 3 figures. Accepted by ApJ
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Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43
Glioblastoma Multiforme (GBM) is an aggressive adult primary brain tumor with poor prognosis. GBM patients develop resistance to the frontline chemotherapy, temozolomide (TMZ). As the connexins (Cx) have been shown to have a complex role in GBM, we investigated the role of Cx43 in TMZ resistance. Cx43 was increased in the TMZ-resistant low passage and cell lines. This correlated with the data in The Cancer Genome Atlas. Cx43 knockdown, reporter gene assays, chromatin immunoprecipitation assay, real-time PCR and western blots verified a role for Cx43 in TMZ resistance. This occurred by TMZ-resistant GBM cells being able to activate epidermal growth factor receptor (EGFR). In turn, EGFR activated the JNK-ERK1/2-AP-1 axis to induce Cx43. The increased Cx43 was functional as indicated by gap junctional intercellular communication among the resistant GBM cells. Cell therapy could be a potential method to deliver drugs, such as anti-EGF to tumor cells. Similar strategies could be used to reverse the expression of Cx43 to sensitize GBM cells to TMZ. The studies showed the potential for targeting EGF in immune therapy. These agents can be used in conjunction with stem cell therapy to treat GBM
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Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5
Meningiomas are a diverse group of tumors with a broad spectrum of histologic features. There are over 12 variants of meningioma, whose genetic features are just beginning to be described. Angiomatous meningioma is a World Health Organization (WHO) meningioma variant with a predominance of blood vessels. They are uncommon and confirming the histopathologic classification can be challenging. Given a lack of biomarkers that define the angiomatous subtype and limited understanding of the genetic changes underlying its tumorigenesis, we compared the genomic characteristics of angiomatous meningioma to more common meningioma subtypes. While typical grade I meningiomas demonstrate monosomy of chromosome 22 or lack copy number aberrations, 13 of 14 cases of angiomatous meningioma demonstrated a distinct copy number profile â polysomies of at least one chromosome, but often of many, especially in chromosomes 5, 13, and 20. WHO grade II atypical meningiomas with angiomatous features have both polysomies and genetic aberrations characteristic of other atypical meningiomas. Sequencing of over 560 cancer-relevant genes in 16 cases of angiomatous meningioma showed that these tumors lack common mutations found in other variants of meningioma. Our study demonstrates that angiomatous meningiomas have distinct genomic features that may be clinically useful for their diagnosis
Keck Interferometer Nuller Data Reduction and On-Sky Performance
We describe the Keck Interferometer nuller theory of operation, data reduction, and on-sky performance, particularly as it applies to the nuller exozodiacal dust key science program that was carried out between 2008 February and 2009 January. We review the nuller implementation, including the detailed phasor processing involved in implementing the null-peak mode used for science data and the sequencing used for science observing. We then describe the Level 1 reduction to convert the instrument telemetry streams to raw null leakages, and the Level 2 reduction to provide calibrated null leakages. The Level 1 reduction uses conservative, primarily linear processing, implemented consistently for science and calibrator stars. The Level 2 processing is more flexible, and uses diameters for the calibrator stars measured contemporaneously with the interferometerâs K-band cophasing system in order to provide the requisite accuracy. Using the key science data set of 462 total scans, we assess the instrument performance for sensitivity and systematic error. At 2.0 Jy we achieve a photometrically-limited null leakage uncertainty of 0.25% rms per 10 minutes of integration time in our broadband channel. From analysis of the Level 2 reductions, we estimate a systematic noise floor for bright stars of ~0.2% rms null leakage uncertainty per observing cluster in the broadband channel. A similar analysis is performed for the narrowband channels. We also provide additional information needed for science reduction, including details on the instrument beam pattern and the basic astrophysical response of the system, and references to the data reduction and modeling tools
Extrapair paternity in two populations of the socially monogamous Thorn-tailed Rayadito Aphrastura spinicauda (Passeriformes: Furnariidae)
Studies on extrapair paternity (EPP) are key to understanding the ecological and evolutionary drivers of variation in avian mating strategies, but information is currently lacking for most tropical and subtropical taxa. We describe the occurrence of EPP in two populations of a South American socially monogamous bird, the Thorn-tailed Rayadito, based on data from 266 broods and 895 offspring that were sampled during six breeding seasons in north-central and southern Chile. In the northern population, 21% of the broods contained at least one extrapair young and 14% of all offspring were sired by an extrapair male, while in the southern population, we detected extrapair offspring (EPO) in 14% of the broods, and 6% of all offspring were EPO. Variation in the frequency of EPP could stem from population differences in the duration of the breeding season or the density of breeding individuals. Other factors such as differences in breeding synchrony and variation in food availability need to be evaluated. More reports on EPP rates are necessary to determine the patterns of taxonomic and geographic variation in mating strategies in Neotropical birds, and to better understand the differences in ecological dynamics between northern and southern hemisphere populations.Fil: Botero Delgadillo, Esteban. Max Plank Institute For Ornithology; Alemania. SELVA: InvestigaciĂłn para la ConservaciĂłn en el NeotrĂłpico; Colombia. Universidad de Chile; ChileFil: Quirici, VerĂłnica. Universidad AndrĂ©s Bello; ChileFil: Poblete, Yanina. Universidad de Las AmĂ©ricas; ChileFil: Ippi, Silvina Graciela. Universidad Nacional del Comahue. Centro Regional Universitario Bariloche. Departamento de EcologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Patagonia Norte; ArgentinaFil: Kempenaers, Bart. Max Plank Institute For Ornithology; AlemaniaFil: VĂĄsquez, Rodrigo A.. Universidad de Chile; Chil
The dusty AGB star RS CrB: first mid-infrared interferometric observations with the Keck Telescopes
We report interferometric observations of the semi-regular variable star RS
CrB, a red giant with strong silicate emission features. The data were among
the first long baseline mid-infrared stellar fringes obtained between the Keck
telescopes, using parts of the new nulling beam combiner. The light was
dispersed by a low-resolution spectrometer, allowing simultaneous measurement
of the source visibility and intensity spectra from 8 to 12 microns. The
interferometric observations allow a non-ambiguous determination of the dust
shell spatial scale and relative flux contribution. Using a simple
spherically-symmetric model, in which a geometrically thin shell surrounds the
stellar photosphere, we find that ~30% to ~70% of the overall mid-infrared flux
- depending on the wavelength - originates from 7-8 stellar radii. The derived
shell opacity profile shows a broad peak around 11 microns (tau ~ 0.06),
characteristic of Mg-rich silicate dust particles.Comment: Accepted for publication in ApJ Letter
The near-infrared size-luminosity relations for Herbig Ae/Be disks
We report the results of a sensitive K-band survey of Herbig Ae/Be disk sizes
using the 85-m baseline Keck Interferometer. Targets were chosen to span the
maximum range of stellar properties to probe the disk size dependence on
luminosity and effective temperature. For most targets, the measured
near-infrared sizes (ranging from 0.2 to 4 AU) support a simple disk model
possessing a central optically-thin (dust-free) cavity, ringed by hot dust
emitting at the expected sublimation temperatures (T_sub~1000-1500K).
Furthermore, we find a tight correlation of disk size with source luminosity R
propto L^(1/2) for Ae and late Be systems (valid over more than 2 decades in
luminosity), confirming earlier suggestions based on lower-quality data.
Interestingly, the inferred dust-free inner cavities of the highest luminosity
sources (Herbig B0-B3 stars) are under-sized compared to predictions of the
optically-thin cavity model, likely due to optically-thick gas within the inner
AU.Comment: Accepted by Astrophysical Journal; 24 pages, 4 figures, 4 table
Milliarcsecond N-Band Observations of the Nova RS Ophiuchi: First Science with the Keck Interferometer Nuller
We report observations of the nova RS Ophiuchi (RS Oph) using the Keck
Interferometer Nuller (KIN), approximately 3.8 days following the most recent
outburst that occurred on 2006 February 12. These observations represent the
first scientific results from the KIN, which operates in N-band from 8 to 12.5
microns in a nulling mode. By fitting the unique KIN data, we have obtained an
angular size of the mid-infrared continuum of 6.2, 4.0, or 5.4 mas for a disk
profile, gaussian profile (FWHM), and shell profile respectively. The data show
evidence of enhanced neutral atomic hydrogen emission and atomic metals
including silicon located in the inner spatial regime near the white dwarf (WD)
relative to the outer regime. There are also nebular emission lines and
evidence of hot silicate dust in the outer spatial region, centered at ! 17 AU
from the WD, that are not found in the inner regime. Our evidence suggests that
these features have been excited by the nova flash in the outer spatial regime
before the blast wave reached these regions. These identifications support a
model in which the dust appears to be present between outbursts and is not
created during the outburst event. We further discuss the present results in
terms of a unifying model of the system that includes an increase in density in
the plane of the orbit of the two stars created by a spiral shock wave caused
by the motion of the stars through the cool wind of the red giant star. These
data show the power and potential of the nulling technique which has been
developed for the detection of Earth-like planets around nearby stars for the
Terrestrial Planet Finder Mission and Darwin missions.Comment: 41 pages, 10 figure
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