Model Tikus Omenn Syndrome

In 1965, Gilbert Omenn described a rare, inherited disorder which produced paradoxical combination of immunodeficiency and immune dysregulation. The term Omenn Syndrome was coined originating from this report. More than 40 years ago since it first described, the pathogenesis of OS has remained mysterious and these could be due to unavailable animal model for OS yet. This paper evaluates and discusses 2 murine models of OS that have been found and developed recently by 2 research groups from Japan and Italia. These two murine models bearing mutation in the V(D)J recombination analogous to those causing human OS. These two mouse models have been recapitulate the disease and provide insight into the pathogenesis of OS and also it relation with immunodeficiency combined with autoimmunity and atopy in OS and other related diseases

Effect of Steamed Broccoli Juice (Brassica Oleraceae L. Var. Italica) to the Serum Interleukin 8 Level in Colitis Murine Model

Background: Ulcerative colitis (UC) is a bowel inflammation that happens in the colon and rectum. In UC there is an increased level of inflammatory mediators, one of which is interleukin-8 (IL-8), the main chemoattractant for polymorphonuclear (PMN) inflammatory cells causing inflammation to worsen. Broccoli (Brassica oleraceae L. var. italica) contains sulforaphane which can inhibit nuclear factor kappa B (NF-ĸB), resulting in the decrease of IL-8. This study was performed to identify the effect of steamed broccoli juice to the serum interleukin-8 level in murine model of colitis.Method: This study was a true experimental laboratory study using complete randomized design. Experimental animals being used were 28 murines with Balb/c strain and were divided into 4 intervention groups. Serum IL-8 level was measured by using enzyme-linked immunosorbent assay (ELISA) method. Data analysis was performed using analysis of variance (ANOVA) test, followed by multiple comparisons Tukey honest significant difference (HSD) test (a = 0.05) and p 0.05.Results: The highest mean of IL-8 level was found in the positive control group. This study also showed highly significant difference (p < 0.001) of IL-8 level between positive control group and treatment group.Conclusion: Steamed broccoli juice could decrease serum interleukin-8 level in murine model of colitis

使用汉语拼音提高学生的认读能力 (以 DARUL ULUM 回教高中三年级学生为例)

摘要 ：汉语拼音是识字、学习普通话的有效工具。这项研究的目的是提高 学生认读能力。研究对象是 Darul Ulum 高中三年级学生。通过描述性研究 使用汉语拼音教学过程描述，认读汉字和拼音。数据分析的结果说明，使用 汉语拼音可以提高学生的认读能力。通过课堂实施发现，语音的掌握需要通 过课堂上的强化训练。因此可以说，汉语拼音是认读能力的重要因素之一。 关键词： 汉语拼音 汉语拼音教学 认读能力 Abstact : Hanyu Pinyin is a recognize letters, as an effective tool for learning Mandarin language. This study aims to improve students' ability to recognize letters in class XII MA Darul Ulum. Hanyu Pinyin teaching process described by the descriptive study, to recognize and read Chinese characters and Pinyin. The results of data analysis showed that the use of Hanyu Pinyin can improve the students' ability to recognize letters. Through the implementation in the classroom, its proved that mastering Hanzi needs intensive training. Therefore we can say that Hanyu Pinyin is one of the important factor to recognize letters/ Hanzi

A new class of pluripotent stem cell cytotoxic small molecules

10.1371/journal.pone.0085039PLoS ONE93-POLN