Taloyhtiön pihasaneeraus : Esimerkkikohteena As Oy Kananlaulu

Työn taustana käytettiin lähiöiden suurimman aikakauden, 1960- ja 1970-lukujen kerrostalojen ajankohtaista peruskorjaustarvetta. Peruskorjaustarve koskee niin kiinteistön piha-aluetta kuin kiinteistön muitakin osia. Pihojen suurin korjaustarve perustuu kuluneiden kalusteiden, varusteiden, kasvillisuuden ja muiden osien huonokuntoisuuteen. Lisäksi muuttuneet turvallisuusvaatimukset sekä esteettömyyden haasteet tuovat lisätarvetta pihojen saneerauksille. Työni tavoitteena oli lisätä viihtyisyyttä ja parantaa Asunto Oy Kananlaulun piha-aluetta sen saneerauksella. Saneerauksessa huomioidaan metsälähiön tyypilliset pihasuunnittelun erityispiirteet. Piha-alueen analyysin avulla arvioitiin sen nykytilaa paikan päällä kohteessa. Samalla tutustuttiin myös suunnitelma- ja urakka-asiakirjoihin. Työn pohjana tutkittiin kerrostalorakentamisen ja niiden piha-aluerakentamisen kehitystä Suomessa. Tietopohjaksi haettiin tietoa myös kerrostalopihojen kunnostuksesta ja kunnostusprosessista. Tuloksena oli kirjallinen selostus piharakentamisen vaiheista. Työni toimeksiantajana oli VRJ Pohjois-Suomi Oy. Työn tulokset ovat hyödynnettävissä kerrostalopihojen peruskorjaushankkeissa. Asunto Oy Kananlaulun piha-analyysi ja pihasaneeraus voidaan liittää osaksi Kaukovainion kehittämistä. Työn tulokset antavat myös minulle itselleni mahdollisuuden kehittää omaa osaamistani viherrakentamisen työnjohdossa.As a background for the work was used the topical need of renovation in the block of flats in the suburbs built in the 1960- and 1970´s. The renovation need applies both to the yard and the other parts of the property. The biggest need of renovation is based on the poor condition of the worn out equipment, vegetation and other parts of the yard. Furthermore the changed requirements of safety and accessibility increase the renovation need. The goal on my work was to add the comfort and attractiveness of the yard of Asunto Oy Kananlaulu. During the renovation the typical characteristics of a wooden suburb were taken into account. The present situation of the yard was estimated on site. At the same time I familiarized myself the documents of planning and subcontracting. For the background of the work the development of the building of the block of flats and their yards was investigated. Also the renovation of yards and the process of renovation was studied. The result of the work is a written report of the stages of the yard construction. The principal of the work was VRJ Pohjois-Suomi Oy. The results of the work can be utilized in high-rise yards’ renovation projects. The analyses and renovation of the yard can be linked to the development of Kaukovainio area. The results of the work gave me the possibility to develop my own skills on supervision of work at green construction

Whole exome screening identifies novel and recurrent WISP3 mutations causing progressive pseudorheumatoid dysplasia in Jammu and Kashmir-India

We report identification and genetic characterization of a rare skeletal disorder that remained unidentified for decades in a village of Jammu and Kashmir, India. The population residing in this region is highly consanguineous and a lack of understanding of the disorder has hindered clinical management and genetic counseling for the many affected individuals in the region. We collected familial information and identified two large extended multiplex pedigrees displaying apparent autosomal recessive inheritance of an uncharacterized skeletal dysplasia. Whole exome sequencing (WES) in members of one pedigree revealed a rare mutation in WISP3:c.156C > A (NP-003871.1:p.Cys52Ter), that perfectly segregated with the disease in the family. To our surprise, Sanger sequencing the WISP3 gene in the second family identified a distinct, novel splice site mutation c.643+1G > A, that perfectly segregated with the disease. Combining our next generation sequencing data with careful clinical documentation (familial histories, genetic data, clinical and radiological findings), we have diagnosed the families with Progressive Pseudorheumatoid Dysplasia (PPD). Our results underscore the utility of WES in arriving at definitive diagnoses for rare skeletal dysplasias. This genetic characterization will aid in genetic counseling and management, critically required to curb this rare disorder in the families

Mucopolysaccharidosis IVA (Morquio A syndrome) and VI (Maroteaux-Lamy syndrome): under-recognized and challenging to diagnose

OBJECTIVE: Mucopolysaccharidosis IVA (MPS IVA, or Morquio A syndrome) and VI (MPS VI, or Maroteaux-Lamy syndrome) are autosomal recessive lysosomal storage disorders. Skeletal abnormalities are common initial presenting symptoms and, when recognized early, may facilitate timely diagnosis and intervention, leading to improved patient outcomes. Patients with slowly progressing disease and nonclassic phenotypes can be particularly challenging to diagnose. The objective was to describe the radiographic features of patients with a delayed diagnosis of MPS IVA or VI. MATERIALS AND METHODS: This was a retrospective study. The records of 5 MPS IVA and 3 MPS VI patients with delayed diagnosis were reviewed. Radiographs were evaluated by a radiologist with special expertise in skeletal dysplasias. RESULTS: An important common theme in these cases was the appearance of multiple epiphyseal dysplasia (MED) with epiphyseal changes seemingly confined to the capital (proximal) femoral epiphyses. Very few patients had the skeletal features of classical dysostosis multiplex. CONCLUSIONS: Radiologists should appreciate the wide phenotypic variability of MPS IVA and VI. The cases presented here illustrate the importance of considering MPS in the differential diagnosis of certain skeletal dysplasias/disorders, including MED, some forms of spondylo-epiphyseal dysplasia (SED), and bilateral Perthes-like disease. It is important to combine radiographic findings with clinical information to facilitate early testing and accurate diagnosis

First-time patellar dislocation with resultant habitual dislocation two years later, which was not demonstrated on plain X-rays halfway: a case report

We present an instructive case of habitual left patellar dislocation in which the patella had appeared odd due to lateral tilt relative to contralateral side, but had been radiologically confirmed to be on the trochlea at 1 year prior to the referral. An 11-year-old girl presented to our hospital 2 years after the left patella had dislocated with a 'giving way' when cutting to the left. Our physical and radiological examinations confirmed that the left patella was laterally tilted in the patellar groove with the knee in extension but was dislocated in flexion beyond 45°. In spite of these findings, she had been untreated at the previous hospital since all plain X-rays, including a skyline patellar view, had failed to demonstrate the dislocation. Consequently, in addition to reconstruction of medial patellofemoral ligament, she had to undergo a lateral retinacular release, which might have been unnecessary if treated earlier. This case illustrates that first-time patellar dislocation can gradually lead to habitual dislocation subsequently, and that cautious physical examinations in regard to patella tracking are essential since radiological examinations do not always reveal the pathophysiology of patellar instability

Large quantity production with extreme convenience of human SDF-1α and SDF-1β by a Sendai virus vector

AbstractWe describe a robust expression of human stromal cell-derived factor-1α (SDF-1α) and SDF-1β, the members of CXC-chemokine family, with a novel vector system based upon Sendai virus, a non-segmented negative strand RNA virus. Recombinant SDF-1α and SDF-1β were detected as a major protein species in culture supernatants, reached as high as 10 μg/ml. This remarkable enrichment of the products allowed us to use even the crude supernatants as the source for biological and antiviral assays without further concentration nor purification and will thus greatly facilitate to screen their genetically engineered derivatives

Quantum Smoluchowski equation: Escape from a metastable state

We develop a quantum Smoluchowski equation in terms of a true probability distribution function to describe quantum Brownian motion in configuration space in large friction limit at arbitrary temperature and derive the rate of barrier crossing and tunneling within an unified scheme. The present treatment is independent of path integral formalism and is based on canonical quantization procedure.Comment: 10 pages, To appear in the Proceedings of Statphys - Kolkata I