Spatially resolved spectra of 3C galaxy nuclei

We present and discuss visible-wavelength long-slit spectra of four low redshift 3C galaxies obtained with the STIS instrument on the Hubble Space Telescope. The slit was aligned with near-nuclear jet-like structure seen in HST images of the galaxies, to give unprecedented spatial resolution of the galaxy inner regions. In 3C 135 and 3C 171, the spectra reveal clumpy emission line structures that indicate outward motions of a few hundred km s$^{-1}$ within a centrally illuminated and ionised biconical region. There may also be some low-ionisation high-velocity material associated with 3C 135. In 3C 264 and 3C 78, the jets have blue featureless spectra consistent with their proposed synchrotron origin. There is weak associated line emission in the innermost part of the jets with mild outflow velocity. These jets are bright and highly collimated only within a circumnuclear region of lower galaxy luminosity, which is not dusty. We discuss the origins of these central regions and their connection with relativistic jets.Comment: 15 pages incl Tables, 12 diagrams, To appear in A

Complement component 4A protein levels are negatively related to frontal volumes in patients with schizophrenia spectrum disorders

Background: Excessive C4A-gene expression may result in increased microglia-mediated synaptic pruning. As C4A overexpression is observed in schizophrenia spectrum disorders (SSD), this mechanism may account for the altered brain morphology (i.e. reduced volume and cortical thickness) and cognitive symptoms that characterize SSD. Therefore, this study investigates the association of C4A serum protein levels with brain morphology and cognition, and in particular whether this association differs between recent-onset SSD (n = 69) and HC (n = 40). Methods: Serum C4A protein levels were compared between groups. Main outcomes included total gray matter volume, mean cortical thickness and cognitive performance. Regression analysis on these outcomes included C4A level, group (SSD vs. HC), and C4A*Group interactions. All statistical tests were corrected for age, sex, BMI, and antipsychotic medication dose. Follow-up analyses were performed on separate brain regions and scores on cognitive sub-tasks. Results: The group difference in C4A levels was not statistically significant (p = 0.86). The main outcomes did not show a significant interaction effect (p &gt; 0.13) or a C4A main effect (p &gt; 0.27). Follow-up analyses revealed significant interaction effects for the left medial orbitofrontal and left frontal pole volumes (p &lt; 0.001): C4A was negatively related to these volumes in SSD, but positively in HC. Conclusion: This study demonstrated that C4A was negatively related to – specifically – frontal brain volumes in SSD, but this relation was inverse for HC. The results support the hypothesis of complement-mediated brain volume reduction in SSD. The results also suggest that C4A has a differential association with brain morphology in SSD compared to HC.</p

Adverse effects of fullerenes on endothelial cells: Fullerenol C60(OH)24 induced tissue factor and ICAM-1 membrane expression and apoptosis in vitro

We studied the effects of a C60 water suspension at 4 μg/mL (nC60) and the water soluble fullerenol C60(OH)24 at final concentrations of 1–100 μg/mL on human umbilical vein endothelial cells (HUVECs) in culture. We found that a 24 hr treatment of HUVECs with C60(OH)24 at 100 μg/mL significantly increased cell surface expression of ICAM-1(CD54) (67 ± 4% CD54+ cells vs. 19 ± 2 % CD54+ cells in control; p < 0.001). In addition, this treatment induced the expression of tissue factor (CD142) on HUVECs (54 ± 20% CD142+ cells vs 4 ± 2% CD142+ cells in control; p = 0.008) and increased exposure of phosphatidylserine (PS) (29 ± 2% PS+ cells vs. 12 ± 5% PS+ cells in control; p < 0.001). Analysis of cell cycle and DNA fragmentation (TUNEL) showed that both nC60 and C60(OH)24 caused G1 arrest of HUVECs and C60(OH)24 induced significant apoptosis (21 ± 2% TUNEL+ cells at 100 μg/mL of C60(OH)24 vs. 4 ± 2% TUNEL+ cells in control; p < 0.001). We also demonstrated that both nC60 and C60(OH)24 induced a rapid concentration dependent elevation of intracellular calcium [Ca2+]i. This could be inhibited by EGTA, suggesting that the source of [Ca2+]i in fullerene stimulated calcium flux is predominantly from the extracellular environment. In conclusion, fullerenol C60(OH)24 had both pro-inflammatory and pro-apoptotic effects on HUVECs, indicating possible adverse effects of fullerenes on the endothelium

The unfriendly ISM in the radio galaxy 4C12.50 (PKS 1345+12)

The radio source 4C12.50 has often been suggested to be a prime candidate for the link between ultraluminous infrared galaxies and young radio galaxies. A VLBI study of the neutral hydrogen in the nuclear regions of this object shows that most of the gas detected close to the systemic velocity is associated with an off-nuclear cloud (~50 to 100 pc from the radio core) with a column density of ~10^22 T_spin/100 K) cm^(-2) and an HI mass of a few times 10^5 to 10^6 M_sun. We consider a number of possibilities to explain the results. In particular, we discus the possibility that this cloud indicates the presence of a rich and clumpy interstellar medium in the centre, likely left over from the merger that triggered the activity and that this medium influences the growth of the radio source. The location of the cloud -- at the edge of the northern radio jet/lobe -- suggests that the radio jet might be interacting with a gas cloud. This interaction could be responsible for bending the young radio jet. The velocity profile of the gas is relatively broad (~150$ km/s) and we interpret this as kinematical evidence for interaction of the radio plasma with the cloud. We also consider the model where the cloud is part of a broader circumnuclear structure. Only a limited region of this structure would have sufficient background radio brightness and large enough column depth in neutral gas to obtain detectable HI absorption against the counterjet. The VLBI study of the neutral hydrogen in 4C12.50 suggests that HI detected near the systemic velocity (as it is often the case in radio galaxies) may not necessarily be connected with a circumnuclear disk or torus (as is very often assumed) but instead could be a tracer of the large-scale medium that surrounds the active nucleus and that may influence the growth of the young radio source.Comment: 7 pages, 2 figures. Accepted for publication in A&

HI absorption towards nearby compact radio sources

We present the results of HI absorption measurements towards a sample of nearby Compact Steep-Spectrum (CSS) and Giga-Hertz Peaked Spectrum (GPS) radio sources, the CORALZ sample, using the Giant Metrewave Radio Telescope (GMRT). We observed a sample of 18 sources and find 7 new detections. These sources are of lower luminosity than earlier studies of CSS and GPS objects and we investigate any dependence of HI absorption features on radio luminosity. Within the uncertainties, the detection rates and column densities are similar to the more luminous objects, with the GPS objects exhibiting a higher detection rate than for the CSS objects. The relative velocity of the blueshifted absorption features, which may be due to jet-cloud interactions, are within $\sim$$-$250 km s$^{-1}$ and do not appear to extend to values over 1000 km s$^{-1}$ seen for the more luminous objects. This could be due to the weaker jets in these objects, but requires confirmation from observations of a larger sample of sources. There appears to be no evidence of any dependence of HI column density on either luminosity or redshift, but these new detections are consistent with the inverse relation between HI column density and projected linear size.Comment: 10 pages, 6 figures, accepted for publication in MNRA