16 x 25 Ge:Ga Detector Arrays for FIFI LS

We are developing two-dimensional 16 x 25 pixel detector arrays of both unstressed and stressed Ge:Ga photoconductive detectors for far-infrared astronomy from SOFIA. The arrays, based on earlier 5 x 5 detector arrays used on the KAO, will be for our new instrument, the Far Infrared Field Imaging Line Spectrometer (FIFI LS). The unstressed Ge:Ga detector array will cover the wavelength range from 40 to 120 microns, and the stressed Ge:Ga detector array from 120 to 210 microns. The detector arrays will be operated with multiplexed integrating amplifiers with cryogenic readout electronics located close to the detector arrays. The design of the stressed detector array and results of current measurements on several prototype 16 pixel linear arrays are reported. They demonstrate the feasibility of the current concept. ***This paper does not include Figures due to astro-ph size limitations. Please download entire file at http://fifi-ls.mpe-garching.mpg.de/spie.det.ps.gz ***Comment: 8 pages, SPIE Proceedings, Astronomical Telescopes and Instrumentation 200

The effects of star formation on the low-metallicity ISM: NGC4214 mapped with Herschel/PACS spectroscopy

We present Herschel/PACS spectroscopic maps of the dwarf galaxy NC4214 observed in 6 far infrared fine-structure lines: [C II] 158mu, [O III] 88mu, [O I] 63mu, [O I] 146mu, [N II] 122mu, and [N II] 205mu. The maps are sampled to the full telescope spatial resolution and reveal unprecedented detail on ~ 150 pc size scales. We detect [C II] emission over the whole mapped area, [O III] being the most luminous FIR line. The ratio of [O III]/[C II] peaks at about 2 toward the sites of massive star formation, higher than ratios seen in dusty starburst galaxies. The [C II]/CO ratios are 20 000 to 70 000 toward the 2 massive clusters, which are at least an order of magnitude larger than spiral or dusty starbursts, and cannot be reconciled with single-slab PDR models. Toward the 2 massive star-forming regions, we find that L[CII] is 0.5 to 0.8% of the LTIR . All of the lines together contribute up to 2% of LTIR . These extreme findings are a consequence of the lower metallicity and young, massive-star formation commonly found in dwarf galaxies. These conditions promote large-scale photodissociation into the molecular reservoir, which is evident in the FIR line ratios. This illustrates the necessity to move to multiphase models applicable to star-forming clusters or galaxies as a whole.Comment: Accepted for publication in the A&A Herschel Special Issu

China’s emerging global role: dissatisfied responsible great power

China has (re)emerged as a great power in a world not of its own making. The distribution of power in major organisations and the dominant norms of international interactions are deemed to unfairly favour the existing Western powers, and at times obstruct China’s ability to meet national development goals. Nevertheless, engaging the global economy has been a key source of economic growth (thus helping to maintain regime stability), and establishing China’s credentials as a responsible global actor is seen as a means of ensuring continued access to what China needs. As an emerging great power that is also still in many respects a developing country, China’s challenge is to change the global order in ways that do not cause global instability or generate crises that would damage China’s own ability to generate economic growth and ensure political stability

The Charge Form Factor of the Neutron at Low Momentum Transfer from the 2H⃗(e⃗,e′n)p^{2}\vec{\rm H}(\vec{\rm e},{\rm e}'{\rm n}){\rm p} Reaction

We report new measurements of the neutron charge form factor at low momentum transfer using quasielastic electrodisintegration of the deuteron. Longitudinally polarized electrons at an energy of 850 MeV were scattered from an isotopically pure, highly polarized deuterium gas target. The scattered electrons and coincident neutrons were measured by the Bates Large Acceptance Spectrometer Toroid (BLAST) detector. The neutron form factor ratio $G^{n}_{E}/G^{n}_{M}$ was extracted from the beam-target vector asymmetry $A_{ed}^{V}$ at four-momentum transfers $Q^{2}=0.14$, 0.20, 0.29 and 0.42 (GeV/c)$^{2}$.Comment: 5 pages, 3 figures, submitted to Phys. Rev. Let

2019: A Changing International Order? Implications for the Security Environment

KCIS2019 examined the implications of the changing international order for international security. It studied the hypercompetitive, multipolar environment in which we find ourselves, marked by a persistent struggle for influence and position within a “grey zone” of competition. This edited collection features contributions from academic and military experts who have examined the future of the liberal international order and what is at stake. These evidence-based examinations discuss the challenges to the order, and why it has been so difficult to articulate a compelling narrative to support the continuation of American leadership.https://press.armywarcollege.edu/monographs/1922/thumbnail.jp

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration

Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of the patients. This medical need contrasts with a high failure rate of more than 1,000 pre-clinical drug candidates for stroke therapies. Thus, there is a need for translatable mechanisms of neuroprotection and more rigid thresholds of relevance in pre-clinical stroke models. One such candidate mechanism is oxidative stress. However, antioxidant approaches have failed in clinical trials, and the significant sources of oxidative stress in stroke are unknown. We here identify NADPH oxidase type 4 (NOX4) as a major source of oxidative stress and an effective therapeutic target in acute stroke. Upon ischemia, NOX4 was induced in human and mouse brain. Mice deficient in NOX4 (Nox4(-/-)) of either sex, but not those deficient for NOX1 or NOX2, were largely protected from oxidative stress, blood-brain-barrier leakage, and neuronal apoptosis, after both transient and permanent cerebral ischemia. This effect was independent of age, as elderly mice were equally protected. Restoration of oxidative stress reversed the stroke-protective phenotype in Nox4(-/-) mice. Application of the only validated low-molecular-weight pharmacological NADPH oxidase inhibitor, VAS2870, several hours after ischemia was as protective as deleting NOX4. The extent of neuroprotection was exceptional, resulting in significantly improved long-term neurological functions and reduced mortality. NOX4 therefore represents a major source of oxidative stress and novel class of drug target for stroke therapy

The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels

This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 3–8 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was assessed by measuring urinary excretion of toxic metals, both before and after oral dimercaptosuccinic acid (DMSA). Multiple positive correlations were found between the severity of autism and the urinary excretion of toxic metals. Variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA and the level of RBC glutathione (adjusted R2 of 0.22–0.45, P < .005 in all cases). This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals

Measurement of the proton electric to magnetic form factor ratio from \vec ^1H(\vec e, e'p)

We report the first precision measurement of the proton electric to magnetic form factor ratio from spin-dependent elastic scattering of longitudinally polarized electrons from a polarized hydrogen internal gas target. The measurement was performed at the MIT-Bates South Hall Ring over a range of four-momentum transfer squared $Q^2$ from 0.15 to 0.65 (GeV/c)$^2$. Significantly improved results on the proton electric and magnetic form factors are obtained in combination with previous cross-section data on elastic electron-proton scattering in the same $Q^2$ region.Comment: 4 pages, 2 figures, submitted to PR