Pre-Merger Localization of Gravitational-Wave Standard Sirens With LISA I: Harmonic Mode Decomposition

The continuous improvement in localization errors (sky position and distance) in real time as LISA observes the gradual inspiral of a supermassive black hole (SMBH) binary can be of great help in identifying any prompt electromagnetic counterpart associated with the merger. We develop a new method, based on a Fourier decomposition of the time-dependent, LISA-modulated gravitational-wave signal, to study this intricate problem. The method is faster than standard Monte Carlo simulations by orders of magnitude. By surveying the parameter space of potential LISA sources, we find that counterparts to SMBH binary mergers with total mass M~10^5-10^7 M_Sun and redshifts z<~3 can be localized to within the field of view of astronomical instruments (~deg^2) typically hours to weeks prior to coalescence. This will allow targeted searches for variable electromagnetic counterparts as the merger proceeds, as well as monitoring of the most energetic coalescence phase. A rich set of astrophysical and cosmological applications would emerge from the identification of electromagnetic counterparts to these gravitational-wave standard sirens.Comment: 29 pages, 12 figures, version accepted by Phys Rev

Complete Wetting of Gluons and Gluinos

Complete wetting is a universal phenomenon associated with interfaces separating coexisting phases. For example, in the pure gluon theory, at $T_c$ an interface separating two distinct high-temperature deconfined phases splits into two confined-deconfined interfaces with a complete wetting layer of confined phase between them. In supersymmetric Yang-Mills theory, distinct confined phases may coexist with a Coulomb phase at zero temperature. In that case, the Coulomb phase may completely wet a confined-confined interface. Finally, at the high-temperature phase transition of gluons and gluinos, confined-confined interfaces are completely wet by the deconfined phase, and similarly, deconfined-deconfined interfaces are completely wet by the confined phase. For these various cases, we determine the interface profiles and the corresponding complete wetting critical exponents. The exponents depend on the range of the interface interactions and agree with those of corresponding condensed matter systems.Comment: 15 pages, 5 figure

QCD strings ending on domain walls --- a complete wetting phenomenon in SUSY QCD

In the context of M-theory, Witten has argued that an intriguing phenomenon occurs, namely that QCD strings can end on domain walls. We present a simpler explanation of this effect using effective field theory to describe the behavior of the Polyakov loop and the gluino condensate in N = 1 supersymmetric QCD. We describe how domain walls separating distinct confined phases appear in this effective theory and how these interfaces are completely wet by a film of deconfined phase at the high-temperature phase transition. This gives the Polyakov loop a non-zero expectation value on the domain wall. Consequently, a static test quark which is close to the interface has a finite free energy and the string emanating from it can end on the wall.Comment: LATTICE98(hightemp), 3 pages, 2 figure

Ambiguity-Free Method for Fast and Precise GNSS Differential Positioning

Methods based on integer ambiguity determination, such as the least-squares ambiguity decorrelation adjustment (LAMBDA) method, are currently used for precise global navigation satellite system (GNSS) differential positioning. In the present paper, the author proposes an ambiguity-free method based on a dedicated mixed (stochastic/deterministic) optimization algorithm that, unlike the LAMBDA method, is capable of providing reliable and accurate results using few observation epochs (e.g., 1-cm accuracy with just two epochs), having the additional advantages of insensitivity to cycle slips and impossibility of wrong ambiguity fixation. In addition, it is demonstrated that the application of the linear (deterministic) part of this algorithm yields the correct baseline results much more easily and quickly than methods requiring integer ambiguity determination, provided the initial approximate coordinates are accurate to a few centimeters. However, the use of ambiguity-free methods requires that the integer character of the ambiguities be preserved so that they can be eliminated; therefore no ionosphere-free combination can be computed and the methods are valid only for short baselines (e.g., less than 10 km).Baselga Moreno, S. (2014). Ambiguity-Free Method for Fast and Precise GNSS Differential Positioning. Journal of Surveying Engineering. 140(1):22-27. doi:10.1061/(ASCE)SU.1943-5428.0000111S2227140

"PolyMin": software for identification of the minimum number of polymorphisms required for haplotype and genotype differentiation

Background Analysis of allelic variation for relevant genes and monitoring chromosome segment transmission during selection are important approaches in plant breeding and ecology. To minimize the number of required molecular markers for this purpose is crucial due to cost and time constraints. To date, software for identification of the minimum number of required markers has been optimized for human genetics and is only partly matching the needs of plant scientists and breeders. In addition, different software packages with insufficient interoperability need to be combined to extract this information from available allele sequence data, resulting in an error-prone multi-step process of data handling. Results PolyMin, a computer program combining the detection of a minimum set of single nucleotide polymorphisms (SNPs) and/or insertions/deletions (INDELs) necessary for allele differentiation with the subsequent genotype differentiation in plant populations has been developed. Its efficiency in finding minimum sets of polymorphisms is comparable to other available program packages. Conclusion A computer program detecting the minimum number of SNPs for haplotype discrimination and subsequent genotype differentiation has been developed, and its performance compared to other relevant software. The main advantages of PolyMin, especially for plant scientists, is the integration of procedures from sequence analysis to polymorphism selection within a single program, including both haplotype and genotype differentiation

Breeding Maize Maternal Haploid Inducers

Maize doubled haploid (DH) lines are usually created in vivo, through crosses with maternal haploid inducers. These inducers have the inherent ability of generating seeds with haploid embryos when used to pollinate other genotypes. The resulting haploid plants are treated with a doubling agent and self-pollinated, producing completely homozygous seeds. This rapid method of inbred line production reduces the length of breeding cycles and, consequently, increases genetic gain. Such advantages explain the wide adoption of this technique by large, well-established maize breeding programs. However, a slower rate of adoption was observed in medium to small-scale breeding programs. The high price and/or lack of environmental adaptation of inducers available for licensing, or the poor performance of those free of cost, might explain why smaller operations did not take full advantage of this technique. The lack of adapted inducers is especially felt in tropical countries, where inducer breeding efforts are more recent. Therefore, defining optimal breeding approaches for inducer development could benefit many breeding programs which are in the process of adopting the DH technique. In this manuscript, we review traits important to maize maternal haploid inducers, explain their genetic basis, listing known genes and quantitative trait loci (QTL), and discuss different breeding approaches for inducer development. The performance of haploid inducers has an important impact on the cost of DH line production

Nutrition Controls Mitochondrial Biogenesis in the Drosophila Adipose Tissue through Delg and Cyclin D/Cdk4

Mitochondria are cellular organelles that perform critical metabolic functions: they generate energy from nutrients but also provide metabolites for de novo synthesis of fatty acids and several amino acids. Thus mitochondrial mass and activity must be coordinated with nutrient availability, yet this remains poorly understood. Here, we demonstrate that Drosophila larvae grown in low yeast food have strong defects in mitochondrial abundance and respiration activity in the larval fat body. This correlates with reduced expression of genes encoding mitochondrial proteins, particularly genes involved in oxidative phosphorylation. Second, genes involved in glutamine metabolism are also expressed in a nutrient-dependent manner, suggesting a coordination of amino acid synthesis with mitochondrial abundance and activity. Moreover, we show that Delg (CG6338), the Drosophila homologue to the alpha subunit of mammalian transcription factor NRF-2/GABP, is required for proper expression of most genes encoding mitochondrial proteins. Our data demonstrate that Delg is critical to adjust mitochondrial abundance in respect to Cyclin D/Cdk4, a growth-promoting complex and glutamine metabolism according to nutrient availability. However, in contrast to nutrients, Delg is not involved in the regulation of mitochondrial activity in the fat body. These findings are the first genetic evidence that the regulation of mitochondrial mass can be uncoupled from mitochondrial activity

Frequency, type, and distribution of EST-SSRs from three genotypes of Lolium perenne, and their conservation across orthologous sequences of Festuca arundinacea, Brachypodium distachyon, and Oryza sativa

<p>Abstract</p> <p>Background</p> <p>Simple sequence repeat (SSR) markers are highly informative and widely used for genetic and breeding studies in several plant species. They are used for cultivar identification, variety protection, as anchor markers in genetic mapping, and in marker-assisted breeding. Currently, a limited number of SSR markers are publicly available for perennial ryegrass (<it>Lolium perenne</it>). We report on the exploitation of a comprehensive EST collection in <it>L. perenne </it>for SSR identification. The objectives of this study were 1) to analyse the frequency, type, and distribution of SSR motifs in ESTs derived from three genotypes of <it>L. perenne</it>, 2) to perform a comparative analysis of SSR motif polymorphisms between allelic sequences, 3) to conduct a comparative analysis of SSR motif polymorphisms between orthologous sequences of <it>L. perenne</it>, <it>Festuca arundinacea, Brachypodium distachyon</it>, and <it>O. sativa</it>, 4) to identify functionally associated EST-SSR markers for application in comparative genomics and breeding.</p> <p>Results</p> <p>From 25,744 ESTs, representing 8.53 megabases of nucleotide information from three genotypes of <it>L. perenne</it>, 1,458 ESTs (5.7%) contained one or more SSRs. Of these SSRs, 955 (3.7%) were non-redundant. Tri-nucleotide repeats were the most abundant type of repeats followed by di- and tetra-nucleotide repeats. The EST-SSRs from the three genotypes were analysed for allelic- and/or genotypic SSR motif polymorphisms. Most of the SSR motifs (97.7%) showed no polymorphisms, whereas 22 EST-SSRs showed allelic- and/or genotypic polymorphisms. All polymorphisms identified were changes in the number of repeat units. Comparative analysis of the <it>L. perenne </it>EST-SSRs with sequences of <it>Festuca arundinacea</it>, <it>Brachypodium distachyon</it>, and <it>Oryza sativa </it>identified 19 clusters of orthologous sequences between these four species. Analysis of the clusters showed that the SSR motif generally is conserved in the closely related species <it>F. arundinacea</it>, but often differs in length of the SSR motif. In contrast, SSR motifs are often lost in the more distant related species <it>B. distachyon </it>and <it>O. sativa</it>.</p> <p>Conclusion</p> <p>The results indicate that the <it>L. perenne </it>EST-SSR markers are a valuable resource for genetic mapping, as well as evaluation of co-location between QTLs and functionally associated markers.</p