Achieving peak brightness in an atom laser

In this paper we present experimental results and theory on the first continuous (long pulse) Raman atom laser. The brightness that can be achieved with this system is three orders of magnitude greater than has been previously demonstrated in any other continuously outcoupled atom laser. In addition, the energy linewidth of a continuous atom laser can be made arbitrarily narrow compared to the mean field energy of a trapped condensate. We analyze the flux and brightness of the atom laser with an analytic model that shows excellent agreement with experiment with no adjustable parameters.Comment: 4 pages, 4 black and white figures, submitted to Physical Revie

ProMoEE - A lightweight web editor supporting study research on process models

Process models are not only used for the sole documentation of the numerous processes in an organization. Among others, they are essential artifacts in the context of service-oriented computing. Hence, high quality process models are the enabler for streamlining, prediction, and automation in many fields (e.g., industrial production). Therefore, a proper and effective comprehension of process models and knowledge about factors influencing the creation of such models constitutes a key criterion for this endeavor. The collection and analysis of data in scientific studies help to understand the objective and subjective factors influencing process model creation and comprehension. This work presents an editor for the definition, execution, and analysis of studies in the context of process model creation and comprehension. The editor features a clean design and allows for a fast implementation for conducting and reporting study research, while ensuring the collection of high-quality data

PoN-S : a systematic approach for applying the Physics of Notation (PoN)

Visual Modeling Languages (VMLs) are important instruments of communication between modelers and stakeholders. Thus, it is important to provide guidelines for designing VMLs. The most widespread approach for analyzing and designing concrete syntaxes for VMLs is the so-called Physics of Notation (PoN). PoN has been successfully applied in the analysis of several VMLs. However, despite its popularity, the application of PoN principles for designing VMLs has been limited. This paper presents a systematic approach for applying PoN in the design of the concrete syntax of VMLs. We propose here a design process establishing activities to be performed, their connection to PoN principles, as well as criteria for grouping PoN principles that guide this process. Moreover, we present a case study in which a visual notation for representing Ontology Pattern Languages is designed

Using Insights from Cognitive Neuroscience to Investigate the Effects of Event-Driven Process Chains on Process Model Comprehension

Business process models have been adopted by enterprises for more than a decade. Especially for domain experts, the comprehension of process models constitutes a challenging task that needs to be mastered when creating or reading these models. This paper presents the results we obtained from an eye tracking experiment on process model comprehension. In detail, individuals with either no or advanced expertise in process modeling were confronted with models expressed in terms of Event-driven Process Chains (EPCs), reflecting different levels of difficulty. The first results of this experiment confirm recent findings from one of our previous experiments on the reading and comprehension of process models. On one hand, independent from their level of exper-tise, all individuals face similar patterns, when being confronted with process models exceeding a certain level of difficulty. On the other, it appears that process models expressed in terms of EPCs are perceived differently compared to process models specified in the Business Process Model and Notation (BPMN). In the end, their generalization needs to be confirmed by additional empirical experiments. The presented expe-riment continues a series of experiments that aim to unravel the factors fostering the comprehension of business process models by using methods and theories stemming from the field of cognitive neuroscience and psychology

RALph: A Graphical Notation for Resource Assignments in Business Processes

The business process (BP) resource perspective deals with the management of human as well as non-human resources throughout the process lifecycle. Although it has received increasing attention recently, there exists no graphical notation for it up until now that is both expressive enough to cover well-known resource selection conditions and independent of the BP modelling language. In this paper, we introduce RALph, a graphical notation for the assignment of human resources to BP activities. We define its semantics by mapping this notation to a language that has been formally defined in description logics, which enables its automated analysis. Although we show how RALph can be seamlessly integrated with BPMN, it is noteworthy that the notation is independent of the BP modelling language. Altogether, RALph will foster the visual modelling of the resource perspective in BP

Engineering the N-glycosylation pathway of Nicotiana tabacum for molecular pharming using CRISPR/Cas9.

Molecular pharming in plants offers exciting possibilities to address global access to modern biologics. However, differences in the N-glycosylation pathway including the presence of β(1,2)-xylose and core α(1,3)-fucose can affect activity, potency and immunogenicity of plant-derived proteins. Successful glycoengineering approaches toward human-like structures with no changes in plant phenotype, growth, or recombinant protein expression levels have been reported for Arabidopsis thaliana and Nicotiana benthamiana. Such engineering of N-glycosylation would also be desirable for Nicotiana tabacum, which remains the crop of choice for recombinant protein pharmaceuticals required at massive scale and for manufacturing technology transfer to less developed countries. Here, we generated N. tabacum cv. SR-1 β(1,2)-xylosyltransferase (XylT) and α(1,3)-fucosyltransferase (FucT) knockout lines using CRISPR/Cas9 multiplex genome editing, targeting three conserved regions of the four FucT and two XylT genes. These two enzymes are responsible for generating non-human N-glycan structures. We confirmed full functional knockout of transformants by immunoblotting of total soluble protein by antibodies recognizing β(1,2)-xylose and core α(1,3)-fucose, mass spectrometry analysis of recombinantly produced VRC01, a broadly neutralizing anti-HIV-1 hIgG1 antibody, and Sanger sequencing of targeted regions of the putative transformants. These data represent an important step toward establishing Nicotiana tabacum as a biologics platform for Global Health

Modification of second cancer risk after malignant melanoma by parental history of cancer

The Swedish Family-Cancer Database was used to quantify the incidence of second tumours in melanoma patients with a parental history of cancer. Patients with parents affected by melanoma showed a 32.3-fold risk of second primary melanomas, which was greater than a multiplicative interaction