Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice

Matrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity which has onco-suppressive actions in numerous tumor types

Demonstration of an automated CFD system for three-dimensional flow simulations

In this paper the capabilities of an automated CFD system which is currently available at NLR are demonstrated. Transonic flow around the AS28G wing/body configuration and hypersonic flow through a generic three-dimensional mixed-compression airbreathing inlet are simulated. An assessment of the level of automation of the current CFD-system is made. The problem-turnaround time lies within the order of a week for both applications

Visceral artery aneurysm

Background: A 36-year-old female patient with no relevant clinical history was referred to the gastroenterology department for chronic epigastric pain. Blood analysis and gastroscopy were normal. Subsequently, abdominal ultrasonography and CT scan of the abdomen were made

Global coordination and standardisation in marine biodiversity through the World Register of Marine Species (WoRMS) and related databases

The World Register of Marine Species is an over 90% complete open-access inventory of all marine species names. Here we illustrate the scale of the problems with species names, synonyms, and their classification, and describe how WoRMS publishes online quality assured information on marine species.Within WoRMS, over 100 global, 12 regional and 4 thematic species databases are integrated with a common taxonomy. Over 240 editors from 133 institutions and 31 countries manage the content. To avoid duplication of effort, content is exchanged with 10 external databases. At present WoRMS contains 460,000 taxonomic names (from Kingdom to subspecies), 368,000 species level combinations of which 215,000 are currently accepted marine species names, and 26,000 related but non-marine species. Associated information includes 150,000 literature sources, 20,000 images, and locations of 44,000 specimens. Usage has grown linearly since its launch in 2007, with about 600,000 unique visitors to the website in 2011, and at least 90 organisations from 12 countries using WoRMS for their data management.By providing easy access to expert-validated content, WoRMS improves quality control in the use of species names, with consequent benefits to taxonomy, ecology, conservation and marine biodiversity research and management. The service manages information on species names that would otherwise be overly costly for individuals, and thus minimises errors in the application of nomenclature standards. WoRMS' content is expanding to include host-parasite relationships, additional literature sources, locations of specimens, images, distribution range, ecological, and biological data. Species are being categorised as introduced (alien, invasive), of conservation importance, and on other attributes. These developments have a multiplier effect on its potential as a resource for biodiversity research and management. As a consequence of WoRMS, we are witnessing improved communication within the scientific community, and anticipate increased taxonomic efficiency and quality control in marine biodiversity research and management

BERMS, ERMS and WORMS: Community tools to facilitate our knowledge of marine biodiversity

The World Register of Marine Species (WoRMS) celebrated its 10th anniversary in 2017. Over thepast ten years, the content of WoRMS has grown steadily, currently containing more than 242,000accepted marine species names. WoRMS is therefore unique: there is no comparable globaldatabase for marine species, which is driven by a large, global expert community, supported by aData Management Team and can rely on a permanent host institute, dedicated to keeping WoRMSonline. The system has seen several user applications, including facilitating local and regionalmarine species data management and data analysis, but also answering big scientific questions forexample about the estimated number exiting marine species, providing a metric for how much wedo and do not know about life in the oceans.One of the unique features of WoRMS is that it is containing and integrating over 100 global, 12regional and 4 thematic species databases integrated within a common taxonomy. This allowsregional, thematic or ecological expert groups to focus on specific contents of the database,providing additional information and creating community ownership of a specific subcomponentof WoRMS.A regional example of WoRMS is BeRMS, the Belgian Register of Marine Species. Published in 2010,this register enabled to provide an inventory of all marine species encountered within the BelgianExclusive Economic Zone, including the intertidal zone.Now, a major update of the Belgian Census has started. A major literature review, dataminingactivities of marine biogeographic databases such as the European Biogeographic InformationSystem (EurOBIS) and additional species surveys are planned in order to complete this register,allowing to provide a nearly complete assessment of the Belgian marine biodiversity