A Radio--Optical Reference Frame VIII. CCD observations from KPNO and CTIO: internal calibration and first results

In this pilot investigation, precise optical positions in the FK5 system are presented for a set of 16 compact extragalactic radio sources, which will be part of the future radio--optical reference frame. The 0.9 m KPNO and CTIO telescopes equipped with 2K CCD's have been used for this project. The astrometric properties of these instruments are investigated in detail. New techniques of using wide field CCD observations for astrometry in general are developed. An internal precision of 5 to 31 mas in position per single exposure is found, depending on the brightness of the object. The tie to the primary optical reference system is established by photographic astrometry using dedicated astrographs on both hemispheres. An accuracy of $\approx 30$ mas per source is estimated for the multi--step reduction procedure when based on the future Hipparcos catalog, while the FK5--based positions suffer from system errors of 100 to 200 mas as compared to the radio positions. This work provides a contribution to the international effort to link the Hipparcos instrumental coordinate system to the quasi--inertial VLBI radio reference frame. Precise radio and optical astrometry of a large sample of compact extragalactic sources will also contribute to the astrophysics of these objects by comparing the respective centers of emission at the optical and radio wavelengths.Comment: AAS v.4 LaTeX, 2 parts on 1 file (main text + deluxetable), accepted by AJ, Dec.95, fig. with reprint

A Compound model for the origin of Earth's water

One of the most important subjects of debate in the formation of the solar system is the origin of Earth's water. Comets have long been considered as the most likely source of the delivery of water to Earth. However, elemental and isotopic arguments suggest a very small contribution from these objects. Other sources have also been proposed, among which, local adsorption of water vapor onto dust grains in the primordial nebula and delivery through planetesimals and planetary embryos have become more prominent. However, no sole source of water provides a satisfactory explanation for Earth's water as a whole. In view of that, using numerical simulations, we have developed a compound model incorporating both the principal endogenous and exogenous theories, and investigating their implications for terrestrial planet formation and water-delivery. Comets are also considered in the final analysis, as it is likely that at least some of Earth's water has cometary origin. We analyze our results comparing two different water distribution models, and complement our study using D/H ratio, finding possible relative contributions from each source, focusing on planets formed in the habitable zone. We find that the compound model play an important role by showing more advantage in the amount and time of water-delivery in Earth-like planets.Comment: Accepted for publication in The Astrophysical Journa

Low-mass star formation in CG1: a diffraction limited search for pre-main sequence stars next to NX Puppis

Using adaptive optics at the ESO 3.6m telescope, we obtained diffraction limited JHK-images of the region around the Herbig AeBe star NX Pup. We clearly resolved the close companion (sep. 0.128") to NX Pup -- originally discovered by HST -- and measured its JHK magnitudes. A third object at a separation of 7.0" from NX Pup was identified as a classical T Tauri star so that NX Pup may in fact form a hierarchical triple system. We discuss the evolutionary status of these stars and derive estimates for their spectral types, luminosities, masses and ages.Comment: Latex using l-aa-ps.sty with links to 5 postscript figures. Complete postscript version also available at http://lucky.astro.uni-wuerzburg.de/ Accepted for publication in A&

Is mechanical stress an important pathogenic factor in hidradenitis suppurativa?

Hidradenitis suppurativa (HS) is a chronic of recurrent, inflammatory, follicular disease that usually presents after puberty with painful deep-seated, inflamed lesions in the inverse skin areas of the body. It has been hypothesized that mechanical pressure or friction is a risk factor for HS. We describe the case of a man with a lower leg amputation who presented HS-like lesions on his leg stump after wearing a leg prosthesis. Although pilonidal sinus-like disease could not be excluded, we diagnosed him with HS-like lesions, induced by prosthesis-related friction. We argue that this case supports the concept that mechanical friction and a warm humid microclimate by occlusion contribute to HS development

Diagnosis of Fanconi Anemia: Mutation Analysis by Multiplex Ligation-Dependent Probe Amplification and PCR-Based Sanger Sequencing

Fanconi anemia (FA) is a rare inherited disease characterized by developmental defects, short stature, bone marrow failure, and a high risk of malignancies. FA is heterogeneous: 15 genetic subtypes have been distinguished so far. A clinical diagnosis of FA needs to be confirmed by testing cells for sensitivity to cross-linking agents in a chromosomal breakage test. As a second step, DNA testing can be employed to elucidate the genetic subtype of the patient and to identify the familial mutations. This knowledge allows preimplantation genetic diagnosis (PGD) and enables prenatal DNA testing in future pregnancies. Although simultaneous testing of all FA genes by next generation sequencing will be possible in the near future, this technique will not be available immediately for all laboratories. In addition, in populations with strong founder mutations, a limited test using Sanger sequencing and MLPA will be a cost-effective alternative. We describe a strategy and optimized conditions for the screening of FANCA, FANCB, FANCC, FANCE, FANCF, and FANCG and present the results obtained in a cohort of 54 patients referred to our diagnostic service since 2008. In addition, the follow up with respect to genetic counseling and carrier screening in the families is discussed

Objective classification of residents based on their psychomotor laparoscopic skills

Background - From the clinical point of view, it is important to recognize residents’ level of expertise with regard to basic psychomotor skills. For that reason, surgeons and surgical organizations (e.g., Acreditation Council for Graduate Medical Education, ACGME) are calling for assessment tools that credential residents as technically competent. Currently, no method is universally accepted or recommended for classifying residents as ‘‘experienced,’’ ‘‘intermediates,’’ or ‘‘novices’’ according to their technical abilities. This study introduces a classification method for recognizing residents’ level of experience in laparoscopic surgery based on psychomotor laparoscopic skills alone. Methods - For this study, 10 experienced residents (>100 laparoscopic procedures performed), 10 intermediates (10– 100 procedures performed), and 11 novices (no experience) performed four tasks in a box trainer. The movements of the laparoscopic instruments were recorded with the TrEndo tracking system and analyzed using six motion analysis parameters (MAPs). The MAPs of all participants were submitted to principal component analysis (PCA), a data reduction technique. The scores of the first principal components were used to perform linear discriminant analysis (LDA), a classification method. Performance of the LDA was examined using a leave-one-out crossvalidation. Results - Of 31 participants, 23 were classified correctly with the proposed method, with 7 categorized as experienced, 7 as intermediates, and 9 as novices. Conclusions - The proposed method provides a means to classify residents objectively as experienced, intermediate, or novice surgeons according to their basic laparoscopic skills. Due to the simplicity and generalizability of the introduced classification method, it is easy to implement in existing trainers.Biomechanical EngineeringMechanical, Maritime and Materials Engineerin

A first search of excited states double beta and double electron capture decays of Pd110 and Pd102

A search for double beta decays of the palladium isotopes 110Pd and 102Pd into excited states of their daughters was performed and first half-life limits for the 2{\nu}{\beta}{\beta} and 0{\nu}{\beta}{\beta} decays into first excited 0+ and 2+ states of 5.89e19 yr and 4.40e19 yr (95% CL) for the 110Pd decay were obtained. The half-life limits for the corresponding double electron capture transition of 102Pd are 7.64e18 yr and 2.68e18 yr (95% CL) respectively. These are the first measurements for 102Pd.Comment: Updated to published version. Refined analysis and minor text changes. Half-life limits change

Herkomst in de supermarkt; Consumenten over de rol van herkomst bij hun voedselaankopen

Nederland kent steeds meer initiatieven die zich bezighouden met de herkomst van voedselproducten. Dit sluit aan op de maatschappelijke ontwikkeling voor meer aandacht voor authenticiteit en duurzaamheid. Voor consumenten betekent herkomst niet altijd hetzelfde. Land van herkomst voert de boventoon, maar ook de regio en een boer of een groep boeren worden er onder verstaan. Consumenten relateren herkomst vaak aan verse producten. Herkomst heeft consumentenwaarde, maar is niet doorslaggevend op het moment van aankoop. Die rol is weggelegd voor persoonlijke waarden als smaak, prijs en gezondheid. Daarbij overheerst de kracht van de gewoonte op de winkelvloer